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| 1 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 2 | Microbio- logical examination of infected dental root canals显示文摘 | GOME B P F A PINHEIRO E T GADE-NETO C R | 2004 | Oral Microb Im- munol2004，19，2： | 1 |
| 3 | Global Situation of dengue and dengue haemor-rhagic fever 显示文摘 | Pinheiro F P Corber S J | 1997 | World Health Stat1997，50，1： | 1 |
| 4 | pH effects on the removal of Cu^2+ , Cd^2+ and Pb^2+ from aqueous solution by waste brewery biomass显示文摘 | Marques P Rosa M F Pinheiro H M | 2000 | Bioprocess Engineering2000，23，2： | 1 |
| 5 | Spermatogenic cycle length and spermatogenic efficiency in the gerbil ( Meriones unguiculatus) 显示文摘 | Segatelli T M Franea L R Pinheiro P F | 2004 | J Androl2004，25，6： | 1 |
| 6 | Lead and calcium binding to fulvic acids:salt effect and competition显示文摘 | Pinheiro J P Mota A M Benedetti M F | | 0，，19： | 1 |
| 7 | Usingcomputational fluid-dynamics (CFD) for the evaluation of beerpasteurization: effect of orientation of cans显示文摘 | AUGUSTO P E D PINHEIRO T F CRISTIANINI M | 2010 | Food Science andTechnology2010，30，4： | 1 |
| 8 | Modulation of tomato pericarp firmness through pH and calcium:Implications for the texture of fresh-cut fruit显示文摘 | PINHEIRO S C F ALMEDIA D P F | 2008 | Postharvest Biology and Technology2008，47，1： | 1 |
| 9 | Securitization of receivables--An analysis of the inherent risks显示文摘 | Pinheiro F A P Savoia J R F | 2009 | Brazilian Review of Finance2009，7，3： | 1 |
| 10 | pH effects of the removal of Cu^2+, Cd^2+ and Pb^2+ from aqueous solution by waste brewery biomass显示文摘 | Marques P A S S Rosa M F Pinheiro H M | 2000 | Bioprocess Engineering2000，23，2： | 1 |
| 11 | Characterization of eight new phlebotomus fever serogroup arboviruses (Bunyaviridae:Phlebovirus) from the Amazon region of Brazil 显示文摘 | Travassos da Rosa A P Tesh R B Pinheiro F P | 1983 | Am J Trop MedHyg1983，32，： | 1 |
| 12 | Modulation of tomato pericarp firmness through pH and calcium:implications for the texture of fresh-cut fruit显示文摘 | PINHEIRO S C F ALMEIDA D P F | 2008 | Postharvest Biology and Technology2008，47，1： | 1 |
| 13 | pH effects on the removal of Cu^2+,Cd^2+ and Pb^2+ from aqueous solution by waste brewery biomass显示文摘 | Marques P Rosa M F Pinheiro H M | 2000 | Bioprocess Engineering2000，23，2： | 1 |
| 14 | Securitization ofreceivables :an analysis of the inherent risks 显示文摘 | Pinheiro F A P Savoia J R F | 2009 | Brazilian Review of Finance2009，7，3： | 1 |
| 15 | Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil显示文摘BACKGROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe disease.The Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil(RISE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active IBD.We report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or CD.AIM To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in Brazil.METHODS This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:Partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to February 2017.The proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were examined.RESULTS The study included 118 CD and 36 UC patients,with mean±SD ages of 43.3±12.6 and 44.9±16.5 years,respectively.The most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least once.Discontinuations/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,respectively.The median time to first mild or no activity was 319(IQR:239-358)d for CD and 320(IQR:288-358)d for UC patients.At 9-12 mo,22.0%of CD and 20.0%of UC patients had active disease.CONCLUSION Although a marked proportion of active IBD patients achieved disease control within one year,the considerable time to achieve this outcome represents an unmet medical need of the current standard of care in a Brazilian real-world setting. | Ligia Yukie Sassaki Sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António S Scotton Cyrla Zaltman Julio Pinheiro Baima Hagata S Ramos Mikaell Alexandre Gouvea Faria Carolina D Gonçalves Isabella Miranda Guimaraes Cristina Flores Heda M B S Amarante Rodrigo Bremer Nones JoséMiguel Luz Parente Murilo Moura Lima Júlio Maria Chebli Maria de Lourdes Abreu Ferrari Julia F Campos Maria G P Sanna Odery Ramos Rogério Serafim Parra Jose J R da Rocha Omar Feres Marley R Feitosa Rosana Fusaro Caratin Juliana Tosta Senra Genoile Oliveira Santana | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
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