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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | In planta functions of the Arabidopsis cytokinin receplor family显示文摘 | Higuchi M Pischke M.S M(a) h(o)nen A.P Miyawaki K Hashimoto Y Seki M Kobayashi M Shinozaki K Kato T Tabata S Helarintta Y Sussman M.R Kalimoto T | | 0，，： | 1 |
| 3 | Investigation of the influence of multiple gasoline direct injections on macroscopic spray quantities at different boundary conditions by means of visualization techniques 显示文摘 | Martin D Pischke P Kneer R | 2010 | International Journal of Engine Research2010，，1： | 1 |
| 4 | Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation : role of ritux- imab 显示文摘 | Stange MA Tutarel O Pischke S | 2010 | Z Gastroentero12010，48，2： | 1 |
| 5 | The structure of wages and investment in general training显示文摘 | Acemoglu D and Pischke J-S | 1998 | Journal of Political Economy1998，，： | 1 |
| 6 | Beyond Becker:Training in Imperfect Labo Markets 显示文摘 | Acemoglu D Pischke J S | 1999 | Economic Jouma1999，109，： | 1 |
| 7 | Changes in the wage structure, family income, and children' s education 显示文摘 | Acemoglu D Pischke J S | 2001 | European Economic Review2001，45，04： | 1 |
| 8 | Hepatitis E vaccine: WHO position paper, May 2015 显示文摘 | Pischke S | 2015 | WER2015，90，18： | 1 |
| 9 | Hepatitis E virus infec- tion as a cause of graft hepatitis in liver transplant recipients 显示文摘 | Pischke S Suneetha PV Baechlein C | 2010 | Liver Transpl2010，16，1： | 1 |
| 10 | Chronic hepatitis E in liver transplant recipients : a significant clinical problem? 显示文摘 | Pischke S Wedemeyer H | 2010 | Minerva Gastroenterol Dietol2010，56，2： | 1 |
| 11 | Influence of different frequencies and insertion depths on the diagnostic accuracy of liver elastography by acoustic radiation force impulse imaging (ARFI)显示文摘 | Andrej Potthoff Dina Attia Sven Pischke Janina Kirschner Ingmar Mederacke Heiner Wedemeyer Michael P. Manns Michael J. Gebel Kinan Rifai | 2013 | European Journal of Radiology2013，，8： | 1 |
| 12 | Chronic hepatitis e in heart transplant recipients 显示文摘 | Pischke S Stieel P Franz B | 2012 | Am J Transplant2012，12，11： | 1 |
| 13 | Ribavirin treatment of acute and chronic hepatitis E: a single-centre experience 显示文摘 | Pischke S Hardtke S Bode U | 2013 | Liver Int2013，33，5： | 1 |
| 14 | Pathogenesis and treatment of hepatitis e virus infection 显示文摘 | Wedemeyer H Pischke S Manns MP | 2012 | Gastroenterology2012，142，6： | 1 |
| 15 | Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1 显示文摘 | MORSE D PISCHKE S E ZHOU Z | 2003 | J Biol Chem2003，278，36： | 1 |
| 16 | Investigation of the influence of multiple gasoline direct injections on macroscopic spray quantities at different boundary conditions by means of visu- alization 显示文摘 | Martin D Pischke P Kneer R | 2010 | lnt J Engine Res2010，11，6： | 1 |
| 17 | Investigation of the influence of multiple gasoline direct injections on macroscopic spray quantities at different boundary conditions by means of visualization techniques显示文摘 | Martin D Pischke P Kneer R | 2010 | International Journal of Engine Research2010，11，6： | 1 |
| 18 | Hepatitis: Hepatitis E vaccination-is HEV 239 the breakthrough显示文摘 | Wedemeyer H Pischke S | 2010 | Nature Reviews Gastroenterology and Hepatology2010，8，： | 1 |
| 19 | Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1 显示文摘 | Morse D Pischke SE Zhou Z | 2003 | J Biol Chem2003，278，36： | 1 |
| 20 | Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1显示文摘 | MORSE D PISCHKE S E ZHOU Z | 2003 | J Biol Chem2003，278，36： | 1 |
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