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283篇 您的检索式:作者名="Pitt E"
    题名 作者 年代 出处 被引量
1Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources.Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames 2014World Journal of Diabetes2014,5,2:13
2Prehospital care in indonesia显示文摘Pitt E Pusponegoro A 2005Emer- gency Medicine Journal2005,22,2:1
3A model of aerobic fungal growth in silage显示文摘Muck R E Pitt R E Leibensperger R Y 1991Grass and Forage Science1991,46,:1
4Prediction of ruminal volatile fatty acids and pH within the net carbohydrate and protein system显示文摘Pitt R E Van KesselJ S Fox D G 1996J Anita Sci1996,74,:1
5Nature of the Electon Interactions in Aryl-substituted polysilanes显示文摘Pitt C G Carey R N Toren E C Jr 1972J Am Chem Soc1972,94,11:1
6Percutaneous translu- minal coronary angioplasty improves survival in acute my- ocardial infarction complicated by cardiogenic shock 显示文摘Lee L Bastes E R Pitt B 1988Circulation1988,78,6:1
7Safety of the blood supply 显示文摘 Pitt E Klein HG 1995JAMA1995,274,:1
8Application of the Cornell net carbohydrate and protein model for cattle consuming forage 显示文摘Fox D G Barry M C Pitt R E 1995Journal of Animal Science1995,73,:1
9Nature of the Electon Interactions in Aryl-substituted polysilanes显示文摘Pitt C G Carey R N Toren E C Jr 1972J Am Chem Soc1972,94,11:1
10Landscape perception : Research,application and theory显示文摘Zube E H Pitt D G Taylor J G 1982Landscape Planning1982,9,1:1
11Rat middle cerebral ar- tery occlusion: evaluation of the model and development of a neurologic examination 显示文摘Bederson JB Pitts LH Tsuji M e al 1986Stroke1986,17,3:1
12Workplace helping:Interactive effects of personality and momentary positive affect显示文摘Conway J M Rogelberg S G Pitts V E 0,,04:1
13Urban storm induced discharge impacts : US Environmental Protection Agency research program review显示文摘Field R Pitt R E 1990Water Sci Technol1990,22,:1
14Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J 1996Journal of Animal Science1996,74,:1
15Kinetics of fiber digestion fi:om in vitro gas production 显示文摘Schofield P Pitt R E Pell A N 1995J Anita Sci1995,72,:1
16The price variability-volume relationship on speculative markets显示文摘Tauchen G E Pitts M 1983Econometrica1983,51,:1
17Time-dependent aspects of the strength and rheology of vegetable tissue green tomatos in impact bruising 显示文摘Pitt R E Chen H L 1976HortScience1976,11,6:1
18A histological comparison of calcium hydrox ide plugs and dentin plugs used for the control of gutta-percha root filling material显示文摘Pitts DL Jones E J 1984J Endod1984,10,:1
19Not All CEOs Are Created Equal as Ad-vertising Spokespersons:Evaluating the Effective CEO Spokesper-son显示文摘Reidenbach E R Pitts E 1986Journal of Advertising1986,15,1:1
20Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells显示文摘Emami K H Brown L G Pitts T E Sun X Vessella R L Corey E 2009Prostate2009,69,:1
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