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17篇 您的检索式：作者名="Poitz"

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		题名	作者	年代	出处	被引量
	1	miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia显示文摘	Ovcharenko D Stolzel F Poitz D	2011	Exp Hematol2011，39，：	1
	2	Tumor-and osteoclast-derived NRP2 in prostate cancer bone metastases显示文摘Understanding the role of neuropilin 2(NRP2)in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone metastasis.We observed a significant upregulation of NRP2 in prostate cancer cells metastasized to bone.Here,we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis,implicating NRP2 as a promising therapeutic target.Since,osteoclasts present in the tumor microenvironment express NRP2,we have investigated the potential effect of targeting NRP2 in osteoclasts.Our results revealed NRP2 negatively regulates osteoclast differentiation and function in the presence of prostate cancer cells that promotes mixed bone lesions.Our study further delineated the molecular mechanisms by which NRP2 regulates osteoclast function.Interestingly,depletion of NRP2 in osteoclasts in vivo showed a decrease in the overall prostate tumor burden in the bone.These results therefore indicate that targeting NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis.	Navatha Shree Polavaram Samikshan Dutta Ridwan Islam Arup K.Bag Sohini Roy David Poitz Jeffrey Karnes Lorenz C.Hofbauer Manish Kohli Brian A.Costello Raffael Jimenez Surinder K.Batra Benjamin A.Teply Michael H.Muders Kaustubh Datta	2021	Bone Research2021，9，2：	1
	3	miR-10a overexpression is associated with NPM1 mutations and MDM4 down regulation in intermediate-risk acute myeloid leukemia显示文摘	Ovcharenko D Slolzel F Poitz D		0，，：	1
	4	Oxygen tension plays a crit- ical role in the hematopoietic microenvironment in vitro 显示文摘	Jing D Wobus M Poitz DM	2012	Haematologica2012，97，3：	1
	5	MiR-lOa overexpressionis associated with NPM1 mutations and MDM4 downregulation inintermediate-risk acute myeloid leukemia 显示文摘	OvcharenkoD Stolzel F Poitz D	2011	Exp Hematol2011，39，10：	1
	6	Transcriptional regulation of Pim-1 kinase in vascular smooth muscle cells and its role for proliferation 显示文摘	Willert M Augstein A Poitz DM	2010	Basic Res Cardiol2010，105，2：	1
	7	Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro显示文摘	Jing D Wobus M Poitz DM	2012	Haematologica2012，97，3：	1
	8	The role of the Eph/eph- fin-system in atherosclerotic plaque development : a complex puzzle 显示文摘	Ende G Poitz DM Strasser RH	2014	Cardiovasc Pathol2014，23，4：	1
	9	miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia显示文摘	Ovcharenko D Stolzel F Poitz D etal	2011	Exp Hematol2011，39，0：	1
	10	Regulation of the Hi&system by micro-RNA 17 and 20a - role during monocyte-to-macrophage differentiation 显示文摘	Poitz DM Augstein A Gradehand C	2013	Mol Immu- nol2013，56，4：	1
	11	Transcriptional regulation of Pim-1 kinase in vascular smooth muscle cells and its role for proliferation显示文摘	Willert M Augstein A Poitz DM	2010	Basic Res Cardiol2010，105，2：	1
	12	Cell -specificand hypoxia -dependent regulation of human HIF -3alpha:inhibition of the expression of HIF target genes in vascular cells显示文摘	Augstein A Poitz DM Braun -Dullaeus EC	2011	Cell Mol Life Sci2011，68，：	1
	13	EpbrinB2/EphA4-mediated activa- tion of endothelial cells increases monoeyte adhesion 显示文摘	Poitz DM Ende G Stutz B	2015	Mol lmmu- nol2015，，：	1
	14	显示文摘	Stenzel O Vogel M Poitz S	1993	Phys Stat Sol1993，140，：	1
	15	Regulation of the Hif- system by micro-RNA 17 and 20a-Role during monocyte-to-macro- phage differentiation 显示文摘	Poitz DM Augstein A Gradehand C	2013	Mol Immunol2013，56，4：	1
	16	MiR-134-mediated 131 integrin expression and function in mesenchymal stem ceils 显示文摘	Poitz D M Stolzel F Arabanian L	2013	Biochim Biophys Acta2013，1833，12：	1
	17	miR-lOa overexpressionis assorialed with NPM1 mutations and MDM4 downregulation ininlermediate-risk acute myeloid leukemia 显示文摘	Ovcharenko I) StMzel F Poitz I) el al	2011	Exp Hematol2011，39，10：	1

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