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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Vapor-liquid equilibrium data for the NH3-H2O system and its description with a modified cubic equation of state显示文摘 | Smolen T M Manley D B Poling B E | 1991 | J Chem Eng Data1991，36，2： | 1 |
| 3 | Ion concentrations in the CO2-NH3 H2O system from 13C NMR spectroscopy 显示文摘 | Holmes II P E Naaz M Poling B E | 1998 | Ind Eng Chem Res1998，37，： | 1 |
| 4 | Phase Ⅱ study of neoadjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a respectable squamous cell carcinoma of the oesophagus显示文摘 | Polee M B Tilanus H W Eskens F A | | 0，，08： | 1 |
| 5 | Phase II study of neo-adjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a resectable squamous cell carcinoma of the esophagus显示文摘 | Polee M B Tilanus H W Eskens F A | | 0，，08： | 1 |
| 6 | The properties of gases and liquids显示文摘 | Reid R C Prausnitz J M Poling B E | 1987 | FIGURE CAPTIONS1987，，9： | 1 |
| 7 | Phase I显示文摘 | Polee M B Eskens F A Vander Burg M E | 2002 | Br J Cancer2002，86，5： | 1 |
| 8 | Ion concentrations in the CO,-NH3-H,O system from I3C NMR spectroscopy显示文摘 | Holmes P E Naaz M Poling B E | 1998 | Industrial & Engineering Chemistry Research1998，37，8： | 1 |
| 9 | Phase Ⅱ study of biweekly administration of paditaxel and cisplatin in patients with advanced esophageal cancer 显示文摘 | Polee M B Tilanus HW Eskens F A | 2002 | Br Cancer2002，86，5： | 1 |
| 10 | Phase study of biweekly administration of paclitaxel and cisplatin in patiens with advanced esophageal cancer显示文摘 | Polee M B Eskens F A Burg M E | 2002 | Br Cancer2002，86，5： | 1 |
| 11 | Ion concentrations in the NH3 -CO2 -H20 system from ~3C NMR spectroscopy 显示文摘 | HOLMES I1 P E NAAZ M POLING B E | 1998 | Ind Eng Chem Res1998，，37： | 1 |
| 12 | Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy显示文摘 | Polee M B Hop W Kok T C | 2003 | Brit J Cancer2003，89，11： | 1 |
| 13 | Phase Ⅱ study of biweekly administration of paclitaxel and cisplatin in patients with advanced oesophageal cancer显示文摘 | Polee M B Eskens F A van der Burg M E | 2002 | Br J Cancer2002，86，5： | 1 |
| 14 | The structure of deferrioxamine E (Nocardamine), a cyclic trihydroxamine 显示文摘 | Hossain M B Dick H Poling M | 1983 | Acta Cryst1983，39，： | 1 |
| 15 | The structure of deferrioxamine E(Nocardamine), a cyclic trihydroxamine 显示文摘 | Hossain M B Dick H Poling M | 1983 | Acta Cryst1983，39，： | 1 |
| 16 | Phase Ⅱ studyof neo-adjuvant chemotherapy wiuh paclitaxel and cisplatin given every 2 weeks for patients with a resectahle squamous cell carcinoma of the esophagus显示文摘 | Polee M B Tilanus H W Eskens F A | 2003 | Ann Oncol2003，14，8： | 1 |
| 17 | Phase Ⅱ study of nco-adjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a resoetable squamous cell carcinoma of the esophagus显示文摘 | POLEE M B TILANUS H W ESKENS F A et M | 2003 | Ann Oncol2003，14，8： | 1 |
| 18 | Phase Ⅱ study of the combination cisplatin, etoposide, 5-fluorouracil and folinic acid in patients with advanced squamous cell carcinoma of the esophagus 显示文摘 | Polee M B Kok T C Siersema P D | 2001 | Anticancer Drugs2001，12，6： | 1 |
| 19 | Phase Ⅱ study of biweekly administration of paclitaxel and cisplatin in patients with advanced oesophageal cancer 显示文摘 | Polee M B Eskens F A van der Burg M E | 2002 | Br J Cancer2002，86，5： | 1 |
| 20 | Phase Ⅰ study of a weekly schedule of a fixed dose of cisplatin and escalating doses of paclitaxel in patients with advanced oesophageal cancer 显示文摘 | Polee M B Verweij J Siersema P D | 2002 | Eur J Cancer2002，38，11： | 1 |
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