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| 1 | F0X01 and F0X03a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim显示文摘Low sensitivity to chem otherapy has been a m ajor challenge in the treatm ent of non-small-cell lung cancer(NSCLC).It is of great clinical significance to discover its mechanisms to improve cell sensitivity to chem otherapeutic drugs.The forkhead box subfam ily O(FOXO)transcriptional factors are downstream factors of the phosphatidylinositol 3-kinase/protein kinase B(PI3K/AKT)pathway and are reported to play pro-apoptotic roles in a variety of cells including NSCLC cells.But th e ir roles and mechanisms in m ediating cell response to chem otherapy remain to be discovered.We proposed that FOX01 and FOX03a may increase the sensitivity o f NSCLC cells to cisplatin.Moreover,we presumed that LY294002,an inh ib ito r of the PI3K/AKT pathway,may enhance the cytotoxic effects of cisplatin through upregulating FOX01 and FOX03a.In the present study,we found that cisplatin initially increased the expressions and nuclear accum ulation o f FOX01 and FOX03a in NSCLC.Knockdown of FOX01 and FOX03a significantly decreased the cell sensitivity to cisplatin in vitro and in vivo.Moreover,inhibition of F0X01 and FOX03a attenuated cisplatininduced cell apoptosis independent of Bim,a pro-apoptotic protein downstream of the FOXOs.Moreover,LY294002 synergistically increased the cytotoxic effects of cisplatin.Mechanistically,LY294002 increased the expressions and nuclear accumulation of FOX01 and FOX03a.Knockdown of FOXCH and FOX03a abrogated the enhancing effect of LY294002 on cisplatin.Taken together,our results suggested that FOX01 and FOX03a sensitize NSCLC cells to cisplatin and mediate the enhancing effects of LY294002 on cisplatin. | Tianyu Sun Jingge Zhang Bo Deng Xiaoqing Fan Tan Long Hua Jin Shaolin Tao Poming Kang Qunyou Tan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 2 |
| 2 | MR Imaging of temporomandibular joint dysfunction: a pictorialreview 1显示文摘 | Xavier Tomas Aume Pomes Juan Berenguer | 2006 | RadioGraphics2006，26，3： | 1 |
| 3 | DBP formation potential of aquatic humic substances显示文摘 | Pomes Michael L Green W Reed Thurman E Michael | 1999 | Journal American Water Works Association1999，91，1： | 1 |
| 4 | Preferential flow and transport ofnitrate and bromide in clay pan soil 显示文摘 | Kelly B P Pomes M L | 1998 | Ground Water1998，36，48： | 1 |
| 5 | Extended end-to-end anastomosis with modified reverse subclavian flap angioplasty显示文摘 | Pome G Butera G | 2001 | Ann Thorac Surg2001，72，3： | 1 |
| 6 | Host cell egress and invasion in- duce marked relocations of glycolytic enzy-mes in Toxoplasma gondii tachyzoites 显示文摘 | Pome! S Luk F C Beckers C J | 2008 | PLoS Pathog2008，4，10： | 1 |
| 7 | Fluorine migration in a soil bed submitted to an electric field: influence of electric potential on fluorine removal 显示文摘 | Pomes V Fernandez A Costarramone N | 1999 | Colloid Surf1999，159，： | 1 |
| 8 | Transient global amnesia 显示文摘 | Cattaino G Querin F Pomes A | 1984 | Acta Neurologica Scandinavica1984，70，： | 1 |
| 9 | Chronic embolization of an atrial septal occluder device: percutaneous or surgical retrieval? A case report 显示文摘 | Ussia GP Abella R Pome G | 2007 | J Cardiovasc M ed (Hagerstown)2007，8，19： | 1 |
| 10 | Fluorine migration in a soil bed submitted to an electric field: influence of electric potential on fluorine removal显示文摘 | Pomes V Fernandez A Costarramone N | 1999 | Colloids Surf A1999，159，： | 1 |
| 11 | Fluorine migration in a soil bed submitted to an electric field: influence of electric potential on fluorine removal显示文摘 | POMES V FERNANDEZ A COSTARRAMONE N | 1999 | Colloids Surfaces A1999，159，： | 1 |
| 12 | MR imaging of the Temporomandibular joint dysfunction: a pictorial review 显示文摘 | Tomas X Pomes J Berenguer J | 2006 | Radiographics2006，26，3： | 1 |
| 13 | Sources and haloacetic acid/trihalomethane formation potentials of aquatic humic substances in the Wakarusa River and Clinton Lake near Lawrence, Kansas 显示文摘 | Pomes M L Larive C K Thurman E M | 2000 | Environ Science Technology2000，34，20： | 1 |
| 14 | Ara h 2: crystalstructure and IgE binding distinguish two subpopulations of peanutallergic patients by epitope diversity显示文摘 | MUELLER G A GOSAVI R A POMES A | 2011 | Allergy2011，66，7： | 1 |
| 15 | Molecular determinants forantibody binding on group 1 house dust mite allergens显示文摘 | Chruszcz M Pomes A Glesner J | 2012 | J BiolChem2012，287，10： | 1 |
| 16 | Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza显示文摘 | Jiang Renwang Lau Kitman Hon Poming | 2005 | Curr Med Chem2005，12，2： | 1 |
| 17 | Computational approaches to the rational design of nanoemulsions, polymeric micelles, and dendrimers for drug delivery显示文摘 | Huynh L Neale C Pomes R | 2012 | Nanomedicine2012，8，1： | 1 |
| 18 | RNA interference meets HIV-1:Will silence be golden显示文摘 | | 2002 | Nat Med2002，8，7： | 1 |
| 19 | MR imaging of the Temporomandibular joint dysfunction: a pictorial review 显示文摘 | Tomas X Pomes J Berenguer J | 2006 | Radiographics2006，26，3： | 1 |
| 20 | Occurrence of alachlor and its sulfonated metabolite in rivers and reservoirs of the Midwestern United States: the importance of sulfonation in the transport of chloroacetanilide herbicides显示文摘 | Thurman E M Goolsyby D A Aga D S Pomes M L Meyer M T | | Env0，，： | 1 |
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