|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Diffuse intestinal ganglioneuromatosis an uncommon manifestation of Cowden syndrome显示文摘Diffuse intestinal ganglioneuromatosis is a hamartomatous polyposis characterized by a disseminated, intramural or transmural proliferation of neural elements involving the enteric plexuses. It has been associated with MEN Ⅱ, neurofibromatosis type 1 and hamartomatous polyposis associated with phosphatase and tensin homolog mutation. We report the case of a female patient with a history of a breast and endometrial tumor who presented in a colonoscopy performed for rectal bleeding diffuse ganglioneuromatosis, which oriented the search for other characteristic findings of Cowden syndrome given the personal history of the patient. The presence of an esophagogastric polyposis was also noted. Cowden syndrome is characterized by skin lesions, but it is rarely diagnosed by these lesions, because they are usually overlooked. Intestinal polyposis is not a major diagnostic criterion but it is very useful for early diagnosis. The combination of colonic polyposis and glucogenic acanthosis should orient the diagnosis to Cowden syndrome. | Maria Teresa Herranz Bachiller Jesus Barrio Andrés Fernando Pons Noelia Alcaide Suárez Rafael Ruiz-Zorrilla Lorena Sancho del Val Sara Lorenzo Pelayo Carlos De La Serna Higuera Ramon Atienza Sánchez Manuel Perez Miranda | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 5 |
| 3 | Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients显示文摘 | Martínez-Llordella Marc Lozano Juan José Puig-Pey Isabel Orlando Giuseppe Tisone Giuseppe Lerut Jan Benítez Carlos Pons Jose Antonio Parrilla Pascual Ramírez Pablo Bruguera Miquel Rimola Antoni Sánchez-Fueyo Alberto | 2008 | Journal of Clinical Investigation2008，，8： | 3 |
| 4 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 5 | Spectral analysis and fingerprinting for biomedia characterisation显示文摘 | Marie-No?lle Pons Sébastien Le Bonté Olivier Potier | 2004 | Journal of Biotechnology2004，，1： | 2 |
| 6 | Increasing biogas production by thermal (70℃) sludge we-treatment prior to thermophilic anaerobic digestion显示文摘 | I Ferrer S Pons℃ F Vázquez | 2008 | Biochemical Engineering2008，42，： | 1 |
| 7 | Study of different internal vapor transports for adsorption cycles with heat regeneration显示文摘 | Szarzynski S Feng Y Pons M | 1997 | Int J Refrig1997，20，6： | 1 |
| 8 | Instrumental texture profile anal- ysis with particular reference to gelled systems显示文摘 | PONS M FISZMAN S M | 1996 | Texture Studies1996，，27： | 1 |
| 9 | Effect of loperamide andbisacodyl on intestinal transit time, fecal weight and short chain fattyacid excretion in the rat显示文摘 | BUSTOS D OGAWA K PONS S | 1991 | Acta Gastroenterologica Latinoamericana1991，21，1： | 1 |
| 10 | Active control of tensegrity systems 显示文摘 | DJOUADI S MOTRO R PONS J C | 1998 | ASCE Journal of Aero- space Engineering1998，22，2： | 1 |
| 11 | Curcumin s ensitizes lung cancer cell stocisplat in induced apopt osis through super oxide anion mediat ed Bcl-2 degradat ion显示文摘 | Chanvorachot e P Pon grak han anon V Wannach aiyasit S | 2009 | Can cer Invest igation2009，27，6： | 1 |
| 12 | Tissue kallikrein defi-ciency aggravates cardiac remodelling and decreases survival aftermyocardial infarction in mice显示文摘 | Pons S Griol-Charhblli V Heymes C | 2008 | EurJ Heart Fail2008，10，4： | 1 |
| 13 | Electrochemically Induced Nuclear Fusion of Deuterium显示文摘 | Fleischmann M Pons S | 1989 | J Electroanal Chem1989，261，： | 1 |
| 14 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 15 | The structure and function of p55PIK reveal a new regulatory subunit forphosphatidylinositol 3-kinase显示文摘 | PONS S TREJO T L SEBASLIAN P | 1995 | Mol Cell Biol1995，15，： | 1 |
| 16 | Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice显示文摘 | Bouhidel O Pons S Souktani R | 2008 | Am J Physiol Heart Circ Physiol2008，295，4： | 1 |
| 17 | Nicotine upregulates its own receptors through enhanced intracellular maturation显示文摘 | Sallette J Pons S Devillers-Thiery A | 2005 | Neuron2005，46，4： | 1 |
| 18 | Noninvasive ventilatory support after lung resectional surgery显示文摘 | AGUILO R TOGORES B PONS S | 1997 | Chest1997，112，1： | 1 |
| 19 | Identification andquantification of geosmin, an earthy odorant contaminatingwines显示文摘 | Darriet P Pons M Lamy S | 2000 | J Agric Food Chem2000，48，10： | 1 |
| 20 | Sensory texture profile, grain physico-chemical characteristics and instrumental measurements of cooked rice显示文摘 | Rousset S Pons B Pilandon C | 1995 | Journal of Texture Studies1995，26，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员