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| 1 | PKM2 sub-cellular localization is involved in oxaliplatin resistance ac-quisition in HT29 human colorectal cancer cell lines 显示文摘 | Gines A Bystrup S Ruiz De Porras V | 2015 | PLoS One2015，10，01： | 1 |
| 2 | Miniaturized Artificial Transmission Line Monolithic Millimeter Wave Frequency Doubler显示文摘 | KANGASLAHTI P ALINIKULA P PORRA V | 2000 | IEEE Transactions on Microwave Theory and Techniques2000，48，4： | 1 |
| 3 | Stability of reconstituted solutions of ceftazidime for injections: an HPLC and CE approach 显示文摘 | Farina A Porra R Cotichini V | 1999 | J Pharm Biomed Anal1999，20，3： | 1 |
| 4 | Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas显示文摘 | Porra V Ferraro-Peyret C Durand C | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 5 | Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues 显示文摘 | Porra V Bernier-Valentin F Trouttet-Masson S | 2002 | J Clin Endocrinol Metab2002，87，4： | 1 |
| 6 | Fresco: Modular composable security services for software-defined networks显示文摘 | SHIN S PORRAS P YEGNESWARAN V | 2013 | Internet Society NDSS2013，，： | 1 |
| 7 | Diagnostic accuracy of fine needle aspiration cytology in parotid tumours显示文摘 | Zerpa Zerpa V Cuesta Gonzales M T Agostini Porras G | 2014 | Acta Otorrinolaringol Esp2014，65，3： | 1 |
| 8 | Silencing of the tmnor suppressor gene SLCSA8 is associated with BRAF mutations in classical papillary thyroid carcinomas显示文摘 | PORRA V FERRARO-PEYRET C DURAND C | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 9 | Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas显示文摘 | Porra V Ferraro-Peyret C Durand C | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 10 | Silencing of the tumor sup- pressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas显示文摘 | Porra V Ferraro PC Durand C | 2005 | J C lin Endocrinol Metab2005，90，： | 1 |
| 11 | Stability of reconstituted so- lutions of ceftazidime for injections: an HPLC and CE approach 显示文摘 | Farina A Porra R Cotichini V | 1999 | J Pharm Biomed Anal1999，20，3： | 1 |
| 12 | Identification and quantification of fetal red blood cells in maternal blood by a dual-color flow cytometric method:evaluation of the Fetal Cell Count kit显示文摘 | Porra V Bernaud J Gueret P | 2007 | Transfusion2007，47，7： | 1 |
| 13 | Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in clas- sical papillary thyroid carcinomas 显示文摘 | Porra V Ferraro-Peyret C Durand C | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 14 | Prostatic 8tltomal sarcoma in a 20-year-old pstient显示文摘 | Borrero JJ Porras V at al | 2005 | Arch Esp Urol2005，58，9： | 1 |
| 15 | C3G contributes to platelet activation and aggregation by regulating major signaling pathways显示文摘C3G is a GEF(guanine nucleotide exchange factor)for Rap GTPases,among which the isoform Rap1b is an essential protein in platelet biology.Using transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemostatic function of platelets through its participation in the thrombin-PKCRap1b pathway.C3G also plays important roles in angiogenesis,tumor growth,and metastasis through its regulation of the platelet secretome.In addition,C3G contributes to megakaryopoiesis and thrombopoiesis.Here,we used a platelet-specific C3G-KO mouse model to further support the role of C3G in hemostasis.C3G-KO platelets showed a significant delay in platelet activation and aggregation as a consequence of the defective activation of Rap1,which resulted in decreased thrombus formation in vivo.Additionally,we explored the contribution of C3G-Rap1b to platelet signaling pathways triggered by thrombin,PMA or ADP,in the referenced transgenic mouse model,through the use of a battery of specific inhibitors.We found that platelet C3G is phosphorylated at Tyr504 by a mechanism involving PKC-Src.This phosphorylation was shown to be positively regulated by ERKs through their inhibition of the tyrosine phosphatase Shp2.Moreover,C3G participates in the ADP-P2Y12-PI3K-Rap1b pathway and is a mediator of thrombin-TXA2 activities.However,it inhibits the synthesis of TXA2 through cPLA2 regulation.Taken together,our data reveal the critical role of C3G in the main pathways leading to platelet activation and aggregation through the regulation of Rap1b. | Sara Gutiérrez-Herrero Cristina Fernández-Infante Luis Hernández-Cano Sara Ortiz-Rivero Carlos Guijas Víctor Martín-Granado JoséRamón González-Porras Jesús Balsinde Almudena Porras Carmen Guerrero | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 16 | Miniaturized artificial transmission-line monolithic millimeter-wave frequency doublers显示文摘 | KANGASLAHTI P ALINIDULA P PORRA V | 2000 | IEEE Transactions on Microwave Theory and Techniques2000，48，4： | 1 |
| 17 | Idetification and quantification of fetal red blood cslls in ma- ternal blood by a dualcolor flow cytometricmeth- od:evaluation of the Fetal Cell Count kit显示文摘 | Porra V Bernaud J Gueret P | 2007 | Transfusion2007，47，7： | 1 |
| 18 | Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas显示文摘 | Porra V Ferraro-Peyret C Durand C | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 19 | Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues显示文摘 | Porra V Bemier-Valentin F Trouttet-Masson S | 2002 | J Clin Endocrinol Metab2002，87，4： | 1 |
| 20 | Spermatic cord rhabdomyoma显示文摘 | Lara C Jurado P Porras V | 2007 | Arch Esp Urol2007，60，： | 1 |
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