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| 1 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 2 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 3 | Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4显示文摘AIM:To investigate the effect of Tenascin C(TNC)on the expression of pro-inflammatory cytokines and matrixmetalloproteinases in human cardiac myofibroblasts(CMF).METHODS:CMF were isolated and cultured from patients undergoing coronary artery bypass grafting.Cultured cells were treated with either TNC(0.1μmol/L,24 h)or a recombinant protein corresponding to different domains of the TNC protein;fibrinogen-like globe(FBG)and fibronectin typeⅢ-like repeats(TNⅢ5-7)(both 1μmol/L,24 h).The expression of the proinflammatory cytokines;interleukin(IL)-6,IL-1β,TNFαand the matrix metalloproteinases;MMPs(MMP1,2,3,9,10,MT1-MMP)was assessed using real time RT-PCR and western blot analysis.RESULTS:TNC increased both IL-6 and MMP3(P<0.01)mR NA levels in cultured human CMF but had no significant effect on the other markers studied.The increase in IL-6 mR NA expression was mirrored by an increase in protein secretion as assessed by enzymelinked immunosorbant assay(P<0.01).Treating CMF with the recombinant protein FBG increased IL-6mR NA and protein(P<0.01)whereas the recombinant protein TNⅢ5-7 had no effect.Neither FBG nor TNⅢ5-7 had any significant effect on MMP3 expression.The expression of toll-like receptor 4(TLR4)in human CMF was confirmed by real time RT-PCR,western blot and immunohistochemistry.Pre-incubation of cells with TLR4neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mR NA and protein expression.CONCLUSION:TNC up-regulates IL-6 expression in human CMF,an effect mediated through the FBG domain of TNC and via the TLR4 receptor. | Azhar Maqbool Emma J Spary Iain W Manfield Michaela Ruhmann Lorena Zuliani-Alvarez Filomena O Gamboa-Esteves Karen E Porter Mark J Drinkhill Kim S Midwood Neil A Turner | 2016 | World Journal of Cardiology2016，8，5： | 4 |
| 4 | Maximal precordial ST-segment depression in leads V4 ~ V6 in patients with inferior wall acute myocardial infarction indicates coronary artery disease involving the left anterior descending coronary artery system显示文摘 | Hasdai D Birnbaum Y Porter A | | 0，，： | 2 |
| 5 | Advances in the Treatment and Outcome of Brainstem Cavernous Malformation Surgery: A Single-Center Case Series of 300 Surgically Treated Patients显示文摘 | Adib A Abla Gregory P Lekovic Jay D Turner Jean G de Oliveira Randall Porter Robert F Spetzler | 2011 | Neurosurgery2011，，2： | 2 |
| 6 | Vegetable oils in fermentation:beneficial effects of low-level supplementation显示文摘 | Jones A M Porter M A | 1998 | J Ind Microbiol Biotechnol1998，21，： | 1 |
| 7 | Innovation forecasting using bibliometrics 显示文摘 | Porter A L | 1995 | Compet Intell Rev1995，9，4： | 1 |
| 8 | Mass spectrometric study of gaseous species in the B-B2O3 system显示文摘 | INGHRAM M G PORTER R F CAHUPK W A | 1956 | Journal of Chemical Physics1956，25，3： | 1 |
| 9 | Colorado potato beetle response to soil amendments:A case in support of the mineral balance hypothesis?显示文摘 | Alyokhin A Porter G Groden E Drummond F | 2005 | Agriculture Ecosystems and Environment2005，109，： | 1 |
| 10 | Localization of human intestinal defensin 5 in Paneth cell granules显示文摘 | Porter E Liu L Oren A | 1997 | Infect Immun1997，65，： | 1 |
| 11 | Fertilizer nitrogen recovery in a no-till wheat-sorghum-fallow-wheat sequence 显示文摘 | Porter L K Follett R F Halvorson A D | 1996 | Agronomy Journal1996，88，： | 1 |
| 12 | Mechanisms of free radical oxidation of unsaturated lipids 显示文摘 | Porter N A Caldwell S E Mills K A | 1995 | Lipids1995，30，4： | 1 |
| 13 | Research Coordination Networks: Evidence of the Relationship Between Funded Interdisciplinary Networking and Scholarly Impact 显示文摘 | Porter A L Garner J Crowl T | 2012 | Bioscience2012，62，3： | 1 |
| 14 | Impaired fasting glucose and outcomes of ST-elevation acute coronary syndrome treated with primary percutaneous intervention among patients without previously known diabetes mellitus 显示文摘 | Porter A Assali AR Zahalka A | 2008 | Am Heart J2008，155，2： | 1 |
| 15 | Alternative approaches to the employee-organization rela- tionship:does investment in employees pay off显示文摘 | TSUI A S PEARCE J L PORTER L W TRIPOLI A M | 1997 | The A cademy of Management Journal1997，40，5： | 1 |
| 16 | Crop responses to climatic variation显示文摘 | Porter John R Semenov Mikhail A | 2005 | Philosophical Transactions of The Royal Society B . 2005 (1463)2005，，： | 1 |
| 17 | Impaired fasting glucose and outcomes of ST - elevation acute coronary syndrome treated with primary percutaneous intervention among patients without previously known diabetes mellitus 显示文摘 | Porter A Assali AR Zahalka A | 2008 | Am Heart J2008，155，2： | 1 |
| 18 | The recrystallization of Ni-base superalloy显示文摘 | RALPH B | 1981 | J Mater Sci1981，16，： | 1 |
| 19 | Innovation forecasting 显示文摘 | Watts R J Porter A L | 1997 | Technological Forecasting and Social Change1997，56，： | 1 |
| 20 | Uniform pricing or pay-as-bid prieing:a dilemma for California and beyond显示文摘 | KAHN A E CRAMTON P C PORTER R H | 2001 | The Electricity Journal2001，14，6： | 1 |
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