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| 1 | Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis. | Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete | 2012 | World Journal of Gastroenterology2012，18，11： | 6 |
| 2 | 日粮磷脂对大西洋鲑鱼早期发育和生长性能的影响显示文摘研究旨在证实大西洋鲑鱼对日粮磷脂的需求,更好地确定其需要水平和时期。因此,通过给大西洋鲑鱼提供磷虾或大豆卵磷脂探讨磷脂对其的影响。首先饲喂鱼苗含蛋白质55%和脂肪17%的饲粮,通过添加磷虾油或大豆磷脂补充脂肪.根据回归分析设计5个水平,分别为总磷脂1.5%(未添加)、2.6%、3.2%、3.6%和4.2%。在1g(受精后1400°dpf)、2.5g(1990°ape)、5g(2350°dpf)、10-20g(2850°dpf)和二龄鲑(3800°dpf)时进行取样。整体存活率高,说明存活率和饲粮磷脂添加水平呈正相关(r2=0.59—0.72)。磷脂促进了鱼苗的生长,且饲喂磷虾磷脂2.6%和大豆磷脂3.6%的鱼增长最快。鱼苗达到2.5g之前与之后生长模式不同,0-2.5g鱼补充磷虾磷脂2.6%和大豆磷脂3.6%后的生长速率(SGR)显著高于基础日粮(P〈0.05),而2.5g-二龄鲑期间,各处理之间没有差异。饲喂未补充磷脂的日粮,2.5g时发现鱼肠道脂肪变性,患病率达20%,饲喂低水平大豆磷脂日粮的鱼肠道脂肪变性患病率达10%,而喂食磷虾油和高水平大豆磷脂(≥3.2%)后以及在后期阶段,肠邋脂肪变性情况开始消失。在生命早期阶段,鲑鱼对日粮磷脂的要求是一致的。 | Taylor J F Martinez-Rubio L Pozo J D Walton J M Tinch A E Migaud H Tocher D R | 2015 | 饲料博览2015，0，8： | 2 |
| 3 | Influence of cytokinins on the expression of phosphate starvation responsive genes in Arabidopsis显示文摘 | Martin A C Pozo D Iglesias J C | 2000 | The Plant Journal2000，24，： | 1 |
| 4 | Immunobiology of vasoactive intestinal peptide (VIP) 显示文摘 | Pozo D Delgado M Martinez M | 2000 | Immunol Today2000，21，1： | 1 |
| 5 | Multicenter hypothermia survey显示文摘 | Danzl D Pozos RS | 1987 | Ann EmergMed1987，16，6： | 1 |
| 6 | A numerical study of cell merger over Cuba - Part Ⅰ : Implementation of the ARPS/MM5 models显示文摘 | Pozo D Borrajero I Marin J C | 2006 | Annales Geophysicae2006，24，11： | 1 |
| 7 | A numerical study of cell merger over Cuba- Part Ⅱ : Sensitivity to environmental conditions显示文摘 | Pozo D Borrajero I Matin J C | 2006 | Annales Geophysicae2006，24，11： | 1 |
| 8 | Fire Detection and Monitoring Using A Multitemporal Technique on AVHRR Mid-Infrared and Thermal Channels显示文摘 | Pozo D Olmo F J Alados-Arboledas L | 1997 | Remote Sensing of Environment1997，60，： | 1 |
| 9 | High serum cholesterol levels are associated with herpes zoster infection after heart transplantation 显示文摘 | Del Pozo J van de Beek D Mandrekar J | 2010 | Clin Infect Dis2010，50，1： | 1 |
| 10 | VIP and PACAP mediated immunomodulation as prospective therapeutic tools显示文摘 | Pozo D | 2003 | Trends Mol Med2003，9，5： | 1 |
| 11 | Survival and growth of seedlings of 12 Chilean rainforest trees in two li~,ht environments: Gas exchange and biomass distribution correlates 显示文摘 | Lusk C H Pozo A D | 2002 | Austral Ecology2002，27，： | 1 |
| 12 | The significance of vasoactive intestinal peptide in immunomodulation 显示文摘 | Delgado M Pozo D Ganea D | 2004 | Pharmacol Rev2004，56，2： | 1 |
| 13 | Expression of the Mella-melatonin receptor mRNA in T and B subsets of lymphocytes from thymus and spleen显示文摘 | Delgado M Fernandez-Santos J M | 1997 | FASEB J1997，11，6： | 1 |
| 14 | Expression of the Mella-melatonin receptor mRNA in T and B subsets of lympho-cytes from thymus and spleen显示文摘 | Pozo D Delgado M Fernandez-Santos J M | | 0，，06： | 1 |
| 15 | Biodegradability of slaughterhouse wastewater with high blood content under anaerobic and aerobic conditions 显示文摘 | Pozo R D Tas D O Dulkadiroglu H | 2003 | J Chem Tech Biotechnol2003，78，4： | 1 |
| 16 | Investigation of ultraviolet light-enhanced H202 oxidation of NOx emissions 显示文摘 | Cooper C D Clausen III C A Pettey L Collins M Pozo de Fernandez M | 2002 | Journal of Environmental Engineering2002，128，1： | 1 |
| 17 | How coping mediates the effect optimism on dis- tress: A study of women with early stage breast cancer显示文摘 | CARVER C S POZO C HARRIS S D | 1993 | Journal of Personality and Social Psychology1993，65，： | 1 |
| 18 | Mechanisms involved in pro- tection afforded by L - arginine in ibuprofen - induced gastric dam- age:role of nitric oxide and prostaglandins显示文摘 | Jimenez D Martin MJ Pozo D | 2002 | Dig Dis Sci2002，47，： | 1 |
| 19 | Coronal fractures of the lateral femoral condyle显示文摘 | LEWIS S L POZO J L MUIRHEAD-ALLWO()D W F | 1989 | Bone Joint Sur1989，71，1： | 1 |
| 20 | Antigenic and molecular characterization of rabies virus in Argentina显示文摘 | Cisterna D Bonaventura R Caillou S Pozo O | 2005 | Virus Res2005，109，2： | 1 |
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