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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | CYP2A6 genetic variationand dexmedetomidine disposition 显示文摘 | Utkarsh K Pratik P Mordechai M | 2012 | Eur J Clin Pharmacol2012，68，6： | 1 |
| 3 | Probabilistic stream line q-ball tractography using the residual bootstrap 显示文摘 | Jeffrey IB Sung WC Pratik M | 2008 | Neurohnage2008，39，1： | 1 |
| 4 | Development and validation of a RP-HPLC method for the determination of dapoxetine hydro- chloride in pharmaceutical dosage form 显示文摘 | Pratik M Ujjwal S Seth AK | 2011 | Int J Pharrn Sci RevRes2011，6，2： | 1 |
| 5 | Reticuloendotheliosis virus sequences within the genomes of field strains of fowlpox virus display variability显示文摘 | Pratik S William M S and Deoki N T | 2003 | J Virol2003，77，10： | 1 |
| 6 | Tumor marker CA-125 as an evaluator and response indicator in ovarian cancer:its quantitative correlation with tumor volume显示文摘 | Pratik K Madan M R Lalit K | 2005 | Med Sci Monit2005，11，2： | 1 |
| 7 | Corrosion inhibition using superhydrophobic films显示文摘 | Philip M Barkhudarov Pratik B Shah Erik B | 2008 | Corrosion Science2008，50，： | 1 |
| 8 | Effect of vanadium on colonic aberrant crypt loci induced in rats by 1,2 Dimethyl hydrazine显示文摘AIM: To investigate the chemo preventive effects of vanadium on rat colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH).METHODS: Male Sprague-Dawley Rats were randomly divided into four groups. Rats in Group A received saline vehicle alone for 16 weeks. Rats in Group B were given DMH injection once a week intraperitoneally for 16 weeks;rats in Group C, with the same DMH treatment as in the Group B, but received 0.5-ppm vanadium in the form ammonium monovanadate ad libitum in drinking water. Rats in the Group D received vanadium alone as in the Group C without DMH injection.RESULTS: Aberrant crypt foci (ACF) were formed in animals in DMH-treated groups at the end of week 16.Compared to DMH group, vanadium treated group had less ACF (P<0.001). At the end of week 32, all rats in DMH group developed large intestinal tumors. Rats treated with vanadium contained significantly few colonic adenomas and carcinomas (P<0.05) compared to rats administered DMH only. In addition, a significant reduction (P<0.05) in colon tumor burden (sum of tumor sizes per animal) was also evident in animals of Group C when compared to those in rats of carcinogen control Group B. The results also showed that vanadium significantly lowered PCNA index in ACF (P<0.005). Furthermore, vanadium supplementation also elevated liver GST and Cyt P-450 activities (P<0.001 and P<0.02, respectively).CONCLUSION: Vanadium in the form of ammonium monovanadate supplemented in drinking water ad libitum has been found to be highly effective in reducing tumor incidence and preneoplastic foci on DMH-induced colorectal carcinogenesis. These findings suggest that vanadium administration can suppress colon carcinogenesis in rats. | PSuresh Kanna CB Mahendrakumar T Chakraborty P Hemalatha Pratik Banerjee M Chatterjee | 2003 | World Journal of Gastroenterology2003，9，5： | 1 |
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