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1篇 您的检索式:作者名="Premendu P. Mathur"
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1PepBind: A Comprehensive Database and Computational Tool for Analysis of Protein-peptide Interactions显示文摘Protein-peptide interactions,where one partner is a globular protein(domain) and the other is a flexible linear peptide,are key components of cellular processes predominantly in signaling and regulatory networks,hence are prime targets for drug design.To derive the details of the protein-peptide interaction mechanism is often a cumbersome task,though it can be made easier with the availability of specifc databases and tools.The Peptide Binding Protein Database(PepBind) is a curated and searchable repository of the structures,sequences and experimental observations of 3100 protein-peptide complexes.The web interface contains a computational tool,protein inter-chain interaction(PICI),for computing several types of weak or strong interactions at the protein-peptide interaction interface and visualizing the identifed interactions between residues in Jmol viewer.This initial database release focuses on providing protein-peptide interface information along with structure and sequence information for protein-peptide complexes deposited in the Protein Data Bank(PDB).Structures in PepBind are classifed based on their cellular activity.More than 40% of the structures in the database are found to be involved in different regulatory pathways and nearly 20% in the immune system.These data indicate the importance of protein- peptide complexes in the regulation of cellular processes.PepBind is freely accessible at http:// pepbind.bicpu.edu.in/.Arindam Atanu Das Om Prakash Sharma Muthuvel Suresh Kumar Ramadas Krishna Premendu P. Mathur 2013Genomics, Proteomics & Bioinformatics2013,11,4:1
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