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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | A four-channel,low-power CMOS charge preamplifier for silicon detectors with medium value of capacitance显示文摘 | RANDAZZO N RUSSO G V PRESTI D L | 1997 | IEEE Transactions on Nuclear Science1997，44，1： | 1 |
| 3 | Recycled tyre rubber modified bitumens for road asphalt mixtures: A literature review显示文摘 | Lo Presti D | 2013 | Construction and Building Materials2013，49，： | 1 |
| 4 | Impact of GPS acquisition strategy on decision probabilitiet; 显示文摘 | BORIO D CAMORIANO L LO PRESTI L | 2008 | IEEE Transactions on Aerospace and Electronic Systems2008，44，3： | 1 |
| 5 | Definition of a laborato ry optimization protocol for road bitumen improved with recy- cled tire rubber显示文摘 | Celauro B Celauro C Lo Presti D | 2012 | Construction and Building Materials2012，37，： | 1 |
| 6 | A pluvial deposition method to reconstitute well-graded sand specimens 显示文摘 | FRETTI C LO PRESTI D C F PEDRONI S | 1995 | Geotech Testing J1995，18，2： | 1 |
| 7 | A pluvial deposition method to reconstitute well-graded sand specimens显示文摘 | FRETTI C LO PRESTI D C F PEDRONI S | 1995 | ASTM Geotechnical Testing Journal1995，18，2： | 1 |
| 8 | Monotonic and cyclic loading behaviour of two sands at small strains显示文摘 | LO PRESTI D C F PALLARA O LANCELLOTTA R ARMANDI M MANISCALCO R | 1993 | Geotechnical Testing Journal1993，16，4： | 1 |
| 9 | Multicast topology inference from measured end-to-end loss 显示文摘 | Duffiled D Horowitz J Presti L | 2002 | IEEE Transaction on Information Theory2002，48，1： | 1 |
| 10 | Multicast Topology Inference from End-to-End Loss显示文摘 | N Duffield J Horowitz F Presti and D Towsley | 2002 | IEEE Transactions on Information Theory ( S0018-9448 )2002，48，1： | 1 |
| 11 | , a multimodality imaging approach显示文摘 | Polizzi V Pergolini A Zampi G Lo Presti M Pino P G Cartoni D et aL Intravenous leiomyomatosis extending to the heart | 2014 | Herz2014，39，： | 1 |
| 12 | Impact of GPS ac- quisition strategy on decision probabilities显示文摘 | Borio D Camoriano L Presti L L | 2008 | IEEE Trans on Aerospace and Electronic Systems2008，44，3： | 1 |
| 13 | Anisotropy of small strain stiffness in Ticino sand显示文摘 | BELLOTTI R JAMIOLKOWSKI M LO PRESTI D C F | 1996 | Geotechnique1996，46，1： | 1 |
| 14 | Hyaluronan-mediated protective effect against cell damage caused by enzymatically produced hydroxyl radicals is dependent on hyaluronan molecular mass显示文摘 | Scott J E Presti D | 1994 | Cell Biochemistry and Function1994，12，： | 1 |
| 15 | Progressive refinement approach to MLE: An application to carrier frequency recovery 显示文摘 | Olmo G Presti L L Bosetto D | 2001 | IEEE Trans Commun2001，49，： | 1 |
| 16 | Impact of GPS acquisition strategy on decision probabilities显示文摘 | Boris D Camoriano L Presti L L | 2008 | IEEE Transactions on Aerospace and Electronic Systems2008，44，3： | 1 |
| 17 | Shear modulus and damping of soils显示文摘 | LO PRESTI D C F JAMIOLKOWSKI M PALLARA O | 1997 | Gé otechnique1997，47，3： | 1 |
| 18 | Haemorheological profile inmetabolic Syndrome显示文摘 | LO PRESTI R SINAGRA D MONTANA M | 2002 | Clin Hemorheol Mic-rocirc2002，26，4： | 1 |
| 19 | Using entangle- ment improves precision in quantum measurements 显示文摘 | D'Ariano G M Presti P L Paris M G | 2001 | Phys Rev Lett A2001，87，27： | 1 |
| 20 | Photoniccrystal silicon nanocluster light-emitting device显示文摘 | PRESTI C D LRRERA A FRANZO G | 2006 | Appl Phys Lett2006，88，03： | 1 |
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