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| 1 | Laparoscopic vs open approach to resection of hepatocellular carcinoma in patients with known cirrhosis:Systematic review and meta-analysis显示文摘AIM: To review the currently available literature comparing laparoscopic to open resection of hepatocellular carcinoma(HCC) in patients with known liver cirrhosis.METHODS: A literature search of MEDLINE, EMBASE, and Cochrane databases was conducted. The search terms used included(laparoscopic OR laparoscopy) AND(hepatic or liver) AND(surgery or resection) AND 'hepatocellular carcinoma' AND(cirrhosis or cirrhotic). Furthermore, to widen the search, we also used the 'related articles' section. Studies reporting a comparison of outcomes and methods of open vs laparoscopic hepatic resection for HCC in patients with liver cirrhosis were included. Meta-analysis of results was performed using a random effects model to compute relative risk(RR) and for dichotomous variablesand standard mean differences(SMD) for continuous variables.RESULTS: A total of 420 patients from 4 cohort studies were included in final analysis. Patients undergoing laparoscopic procedures had statistically less blood loss compared to the open cohort, SMD of-1.01(95%CI:-1.23-0.79), P < 0.001, with a reduced risk of transfusion, RR = 0.19(95%CI: 0.09-0.38), P < 0.001. A wider clearance at tumour resection margins was achieved following a laparoscopic approach, SMD of 0.34(95%CI: 0.08-0.60), P = 0.011. No significant difference was noted between laparoscopic and open resection operative times, SMD of-0.15(95%CI: 0.35-0.05), P = 0.142. The overall RR of suffering from postoperative morbidity is 0.25 in favour of the open surgery cohort(95%CI: 0.17-0.37), P < 0.001. Patients under-going laparoscopic surgery had significantly shorter length of stays in hospital compared to the open cohort, SMD of-0.53(95%CI:-0.73 to-0.32), P < 0.001.CONCLUSION: This review suggests that laparoscopic resection of hepatocellular carcinoma in patients with cirrhosis is safe and may provide improved patient outcomes when compared to the open technique. | Ahmed Twaij Philip H Pucher Mikael H Sodergren Tamara Gall Ara Darzi Long R Jiao | 2014 | World Journal of Gastroenterology2014，20，25： | 16 |
| 2 | Poly: synthesis, crystallinity, and hydrolytic sensitivity in solution and the solid state显示文摘 | Allcock H R Pucher S R | 1994 | Macromolecules1994，27，5： | 1 |
| 3 | Synthesis of Poly(orgnaophosphazenes) with Glycolic Acid Ester and Lactic Acid Ester Side Groups: Prototypes for New Bioerodible Polymers显示文摘 | Alleock H R Pucher S R Scopelianos A G | 1994 | Macromolecules1994，27，1： | 1 |
| 4 | Bioerodible Polymers with a Phosphorusnitrogen Backbone 显示文摘 | Allcock H R Kwon S Pucher S R | 1990 | Polym Prep1990，31，2： | 1 |
| 5 | Poly :synthesis, erystallinity and hydrolytic sensitivity in solution and the solid state 显示文摘 | ALLCOCK H R PUCHER S R SCOPELIANOS A G | 1994 | Macromolecules1994，27，5： | 1 |
| 6 | Poly as substrates for the controlled re- lease of small molecules显示文摘 | ALLCOCK H R PUCHER S R SCOPELIANOS A G | 1994 | Biomaterials1994，15，8： | 1 |
| 7 | Synthesis of poly(orgnaophosphazenes) with glycolic acid ester and lac- tic acid ester side groups:prototypes for new bioerodible polymers 显示文摘 | ALLCOCK H R PUCHER S R SCOPELIANOS A G | 1994 | M acromolecules1994，27，： | 1 |
| 8 | Kinetics of biochar liquefaction显示文摘 | FEINER R SCHWAIGER N PUCHER H | 2014 | Bioenergy Research2014，7，4： | 1 |
| 9 | Bioerodible polymers with aphosphorus-nitrogen backbone显示文摘 | Allcock H R Kwon S Pucher S R | 1990 | Polym Prepr1990，31，2： | 1 |
| 10 | Macromolecules 显示文摘 | Allcock H R Pucher S R Scopelianos A G | 1994 | 27(1): 1-41994，27，1： | 1 |
| 11 | Organic acids of to-bacco plants显示文摘 | PUCHER G W VICKERY H B | 1989 | Chem Rev1989，178，2： | 1 |
| 12 | New Mono-and Trispirocyclotriphosphazenes fromthe Reactions of(NPC12)3with Aromatic Ortho Di-nucleophiles显示文摘 | ALLCOCK H R DIEFENBACH U PUCHER S R | 1994 | Inorg Chem1994，33，14： | 1 |
| 13 | In-situ CO_2-absorption in a dual fluidized bed biomass steam gasifier to produce a hydrogen rich syngas显示文摘 | Pfeifer C Pucher B Hofbauer H | 2007 | International Journal of Chemical Reactor Engineering2007，5，： | 1 |
| 14 | Formation of O/W emulsions by static mixers for pharmaceutical applications 显示文摘 | Kiss N Brenn G Pucher H | 2011 | Chem Eng Sci2011，66，21： | 1 |
| 15 | Poly : synthesis, crystallinity, and hydro- lytic sensitivity in solution and the solid state显示文摘 | ALLCOCK H R PUCHER S R | 1994 | Mac- romolecules1994，27，5： | 1 |
| 16 | Poly(organo-phosphazenes) with poly(alkyl ether) side groups: a study of their water solubility and the swelling characteristics of their hydrogels 显示文摘 | ALLCOCK H R PUCHER S R TURNER M L | 1992 | Macromolecules1992，25，21： | 1 |
| 17 | The metabolism of the organic acids of tobacco plants显示文摘 | PUCHER G W VICKERY H B | 1949 | J Biol Chem1949，178，： | 1 |
| 18 | Poly-synthesis, crystallinity, and hydrolytic sensitivity in solution and the solid-state 显示文摘 | Allcock H R Pucher S R Scopelianos A G | 1994 | Macromolecules1994，27，： | 1 |
| 19 | Synthesis of poly(organophosphazenes) with glycolic acid ester and lactic acid ester side groups: prototypes for new bioerodible polymers显示文摘 | Allcock H R Pucher S R | 1994 | Macromolecules1994，27，1： | 1 |
| 20 | Poly ( organophosp- hazenes)with po|y(alkylether) side groups: a study of their water solubility and the swelling characteristics of their hydro- gels 显示文摘 | Allcock H R Pucher S R Tumer M L | 1992 | Macromolecules1992，25，21： | 1 |
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