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| 1 | Structural Flexibility Enables Alternative Maturation, ARGONAUTE Sorting and Activities of miR168, a Global Gene Silencing Regulator in Plants显示文摘在优核质, RNase-III Dicer 经常生产长度 / 顺序 microRNA (miRNA ) 变体,叫的 isomiRs,由于 miRNA 先锋(pre-miRNAs ) 的内在的 structural/sequence 决定因素。在这研究,我们联合了学习 Arabidopsis miR168 的生物物理学,遗传和生物化学途径,中央植物 silencing 受动器蛋白质 ARGONAUTE1 (AGO1 ) 的关键反馈管理者。我们识别了在植物 pre-miR168 orthologs 之中保存的一个主题,它启用灵活内部基础配对的位于 \O 下面至少三种亚稳的结构的配置。这些配置支持与行动的特殊以前排序的性质和模式产生长度和结构的 isomiR168 变体的其他的、精确 Dicer 劈开事件。在这些 isomiR168s 之中,一与 22-nt 指南海滨双为 AGO10 展出惊人地优先的亲密关系,最靠近的 AGO1 paralog。22-nt miR168-AGO10 建筑群反对 AGO1 累积在 ? 经由及物的 RNAi 的部分,一个沉默扩大过程,维持 ? 适当 AGO1 细胞的动态平衡。而且,我们发现 tombusviral P19 silencing-suppressor 蛋白质在它的 isomiR168 货物之中为 22-nt 形式显示显著地更弱的亲密关系,从而支持调停 AGO1 的抗病毒的 silencing 的指导 AGO10 的抑制。一起拿,这些调查结果显示那结构的灵活性, pre-miRNAs 的一个以前俯看的性质,更加增加通用性和单个 MIRNA 基因,和病原体可能发展了的那一些的规章的潜力能力或机制篡夺这个性质。 | Taichiro Iki Antoine Cléry Nicolas G. Bologna Alexis Sarazin Christopher A. Brosnan Nathan Pumplin Frédéric H.T. Allain Olivier Voinnet | 2018 | Molecular Plant2018，11，8： | 2 |
| 2 | Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions显示文摘 | Fasano A Baudry B Pumplin D W | 1991 | Proc Natl Acad Sci USA1991，88，12： | 1 |
| 3 | New generation of parton distributions with uncertainties from global QCD analysis显示文摘 | PUMPLIN J STUMP D R HUSTON J | 2002 | Journal of High Energy Physics2002，07，012： | 1 |
| 4 | Vibrio cholerae produces a second enterotoxin,which affects intestinal tight junctions显示文摘 | FASANO A BAUDRY B PUMPLIN D W | 1991 | Proc Natl Acad Sci USA1991，88，10： | 1 |
| 5 | Prevention of microsurgical anastomotic thrombosis using aspirin, hepa- rin, and the glycoprotein Ⅱ b/Ⅲ a inhibitor tirofiban 显示文摘 | Chung TL Pumplin DW Holton LH 3rd | 2007 | Plast Reconstr Surg2007，120，5： | 1 |
| 6 | Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junction 显示文摘 | Fasano A Baudry B Pumplin DW | 1991 | Proc Nail Acad Sci USA1991，88，： | 1 |
| 7 | Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junction 显示文摘 | Fasano A Baudry B Pumplin DW | 1991 | Proc NatlAcad Sci USA1991，88，： | 1 |
| 8 | New generation of parton distributions with uncertainties from global QCD analysis 显示文摘 | PUMPLIN J STUMP D R HUSTON J | 2002 | JHEP2002，0207，： | 1 |
| 9 | Light and dark cells of rat vallate taste buds are morphologically distinct cell types显示文摘 | Pumplin DW Yu C Smith DV | 1997 | J Comp Neurol1997，378，38： | 1 |
| 10 | Phosphate in the arbus cular mycorrhizal symbiosis: transport properties and regula tory roles显示文摘 | Javot H Pumplin N Harrison M J | 2007 | Plant Cell and Environment2007，30，2： | 1 |
| 11 | Patton distributions and the strong coupling: CTEQ6AB PDFs显示文摘 | PUMPLIN J BELYAEV A HUSTON J | 2006 | JHEP2006，0602，： | 1 |
| 12 | Vibrio choleraeproduces a second enterotoxin, which affects intestinaltight junction显示文摘 | Fasano A Baudry B pumplin D W | 1991 | Proc Natl Acad Sci USA1991，88，12： | 1 |
| 13 | Medicago truncatu- la Vapyrin is a novel protein required for arbuscular myeorrhi- zal symbiosis显示文摘 | PUMPLIN N MONDO S J TOPP S | 2010 | Plant journal2010，61，： | 1 |
| 14 | Medicago truncatula Vapyrin is a novel protein required for arbuscular mycorrhizal symbiosis显示文摘 | Pumplin N Mondo S J Topp S | 2010 | Plant Journal2010，61，： | 1 |
| 15 | Phosphate in the arbuscular mycorrhizal symbiosis:transport properties and regulatory roles显示文摘 | Javot H Pumplin N Harrison MJ | | 0，，： | 1 |
| 16 | Ultrastrong and stiff layered polymer nanocomposites显示文摘 | Podsiadlo P Kaushik A.K Arruda E.M Waas A.M Shim B.S Xu J Nandivada H Pumplin B.G Lahann J Ramamoorthy A Kotov N.A | | 0，，5847： | 1 |
| 17 | Live-cell imaging reveals periarbuscular membrane domains and organelle location in Medicago truncatula roots during arbuscular mycorrhizal symbiosis显示文摘 | Pumplin N Harrison MJ | 2009 | Plant Physiology2009，151，2： | 1 |
| 18 | Polar localization of a symbiosis-specific phosphate transporter is mediated by a transient reorientation of secretion显示文摘 | Pumplin N Zhang X Noar R D | 2012 | Proceedings of the National Acade- my of Sciences of the United States of America2012，109，11： | 1 |
| 19 | Vibrio cholerae produces a second enterotoxin,which affects intestinaltight junctions 显示文摘 | FASANO A BAUDRY B PUMPLIN D W | 1991 | Proc Natl Acad Sci USA1991，88，12： | 1 |
| 20 | Vibrio cholerae produces a second enterotoxin,which affects intestinal tight junction 显示文摘 | Fasano A Baudry B Pumplin DW | 1991 | Proc Natl Acad Sci USA1991，88，： | 1 |
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