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| 1 | COVID-19 and gut immunomodulation显示文摘The disease coronavirus disease 2019(COVID-19)is a severe respiratory illness that has emerged as a devastating health problem worldwide.The disease outcome is heterogeneous,and severity is likely dependent on the immunity of infected individuals and comorbidities.Although symptoms of the disease are primarily associated with respiratory problems,additional infection or failure of other vital organs are being reported.Emerging reports suggest a quite common co-existence of gastrointestinal(GI)tract symptoms in addition to respiratory symptoms in many COVID-19 patients,and some patients show just the GI symptoms.The possible cause of the GI symptoms could be due to direct infection of the epithelial cells of the gut,which is supported by the fact that(1)The intestinal epithelium expresses a high level of angiotensin-converting enzyme-2 and transmembrane protease serine 2 protein that are required for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into the cells;(2)About half of the severe COVID-19 patients show viral RNA in their feces and various parts of the GI tract;and(3)SARS-CoV-2 can directly infect gut epithelial cells in vitro(gut epithelial cells and organoids)and in vivo(rhesus monkey).The GI tract seems to be a site of active innate and adaptive immune responses to SARS-CoV-2 as clinically,stool samples of COVID-19 patients possess proinflammatory cytokines(interleukin 8),calprotectin(neutrophils activity),and immunoglobulin A antibodies.In addition to direct immune activation by the virus,impairment of GI epithelium integrity can evoke immune response under the influence of systemic cytokines,hypoxia,and changes in gut microbiota(dysbiosis)due to infection of the respiratory system,which is confirmed by the observation that not all of the GI symptomatic patients are viral RNA positive.This review comprehensively summarizes the possible GI immunomodulation by SARS-CoV-2 that could lead to GI symptoms,their association with disease severity,and potential therapeutic interventions. | Koushik Roy Sidra Agarwal Rajib Banerjee Manash K Paul Prabhat K Purbey | 2021 | World Journal of Gastroenterology2021，27，46： | 2 |
| 2 | PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATBI 显示文摘 | Purbey PK Singh S Kumar PP | 2008 | Nucleic Acids Res2008，36，7： | 1 |
| 3 | PDZ domain mediated dimerization and homeodomain - directed specificity are required for high - affinity DNA binding by SATB1 显示文摘 | Purbey PK Singh S Kumar PP | 2008 | Nucleic Acids Res2008，36，7： | 1 |
| 4 | Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regula- ting its transcriptional activity in vivo 显示文摘 | Pavan Kumar P Purbey PK Sinha CK | 2006 | Mol Cell2006，22，2： | 1 |
| 5 | The third dimension of gene regulation: organization of dynamic chromatin loopseape by SATBI显示文摘 | Galande S Purbey P K Notani D | 2007 | Curr Opin Genet Dev2007，17，5： | 1 |
| 6 | The third dimension of gene regulation:organization of dynamic chromatin loop- scape by SATBI显示文摘 | Galande S Purbey KP Notanil D | 2007 | Curr Opin Genet Dev2007，17，5： | 1 |
| 7 | The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1 显示文摘 | Galande S Purbey PK Notani D | 2007 | Curt Opin Genet Dev2007，17，5： | 1 |
| 8 | PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATBI 显示文摘 | Purbey PK Singh S Kumar PP | 2008 | Nucleic Acids Res2008，36，7： | 1 |
| 9 | Phosphorylation of SATB1,a global gene regulator,acts as a molecular switch regulating its transcriptional activity in vivo显示文摘 | Pavan Kumar P Prabhat Kumar Purbey Chandan Kumar Sinha | 2006 | Molecular Cell2006，22，： | 1 |
| 10 | Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1显示文摘 | Prabhat Kumar Purbey Sunita Singh Dimple Notani | 2009 | Molecular and Cellular Biology2009，29，5： | 1 |
| 11 | The third dimen- sion of gene regulation: organization of dynamic chroma- tin loopscape by SATB 1 显示文摘 | Galande S Purbey P K Notani D | 2007 | Current Opinion in Genetics & Development2007，17，5： | 1 |
| 12 | Functional interaction be- tween PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus 显示文摘 | Kumar PP Bischof O PK Purbey | 2007 | Nat Cell Biol2007，9，1： | 1 |
| 13 | Displacement of SATBl-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells显示文摘 | Kumar PP Purbey PK Ravi DS | 2005 | Mol Cell Biol2005，25，5： | 1 |
| 14 | Phosphorylation of SATB1, a Global Gene Regulator, Acts as a Molecular Switch Regulating Its Transcriptional Activity In Vivo显示文摘 | P. Pavan Kumar Prabhat Kumar Purbey Chandan Kumar Sinha Dimple Notani Amita Limaye Ranveer S. Jayani Sanjeev Galande | 2006 | Molecular Cell2006，，2： | 1 |
| 15 | Displacement of SATB1 - bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells 显示文摘 | Kumar PP Purbey PK Ravi DS | 2005 | Mol Cell Biol2005，25，5： | 1 |
| 16 | Endoscopic retrograde cholangiopancreatography at Dhulikhel Hospital: outcome analy- sis显示文摘 | Gurung RB Purbey B Koju R et 81 | 2014 | Kathmandu Univ Med J ( KUMJ)2014，12，45： | 1 |
| 17 | Losses in litehi at various stages of supply chain and changes in fruit quality parameters 显示文摘 | Kumar Vinod Purbey Sushil Kumar Anal Ajit Kumar Dubedi | 2016 | Crop Protection2016，79，： | 1 |
| 18 | PDZ domain-mediated dimeriza- tion and homeodomain-directed specificity are required for high-affini- ty DNA binding by SATB1 显示文摘 | Purbey PK Singh S Kumar PP | 2008 | Nucleic Acids Res2008，36，7： | 1 |
| 19 | The third dimension of gene regulation: organization of dynamic chromatin loopscape by SATB1 显示文摘 | GALANDE S PURBEY P K NOTANI D | 2007 | Curr Opin Genet Dev2007，17，5： | 1 |
| 20 | Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1 显示文摘 | Purbey PK Singh S Notani D | 2009 | Mol Cell Biol2009，29，5： | 1 |
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