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| 1 | Sessile serrated adenoma/polyps: Where are we at in 2016?显示文摘It is currently known that colorectal cancers(CRC) arise from 3 different pathways: the adenoma to carcinoma chromosomal instability pathway(50%-70%); the mutator 'Lynch syndrome' route(3%-5%); and the serrated pathway(30%-35%). The World Health Organization has classified serrated polyps into three types of lesions: hyperplastic polyps(HP),sessile serrated adenomas/polyps(SSA/P) and traditional serrated adenomas(TSA),the latter two strongly associated with development of CRCs. HPs do not cause cancer and TSAs are rare. SSA/P appear to be the responsible precursor lesion for the development of cancers through the serrated pathway. Both HPs and SSA/Ps appear morphologically similar. SSA/P are difficult to detect. The margins are normally inconspicuous. En bloc resection of these polyps can hence be troublesome. A careful examination of borders,submucosal injection of a dye solution(for larger lesions) and resection of a rim of normal tissue around the lesion may ensure total eradication of these lesions. | Rajvinder Singh Leonardo Zorrón Cheng Tao Pu Doreen Koay Alastair Burt | 2016 | World Journal of Gastroenterology2016，22，34： | 13 |
| 2 | Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis显示文摘AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary obstruction.METHODS: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary outcomes.RESULTS: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis, SEMS had lower overall stent dysfunction compared to PS(21.6% vs 46.8%, P < 0.00001) and fewer re-interventions(21.6% vs 56.6%, P < 0.00001), with no difference in complications(13.7% vs 15.9%, P = 0.16). In the secondary analysis, the mean survival rate was higher in the SEMS group(182 d vs 150 d, P < 0.0001), with a higher patency period(250 d vs 124 d, P < 0.0001) and a lower cost per patient(4193.98 vs 4728.65 Euros, P < 0.0985).CONCLUSION: SEMS are associated with lower stent dysfunction, lower re-intervention rates, better survival, and higher patency time. Complications and costs showed no difference. | Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques Bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca AndréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon | 2015 | World Journal of Gastroenterology2015，21，47： | 10 |
| 3 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 4 | Effects of moistructure of glycerol plasticized soy protein显示文摘 | Pu C Li N Z Fei F C | 2005 | Macromol Biosci2005，5，： | 1 |
| 5 | Spectral absorption features as indicators of water status in coast live oak (Quercus agrifolia) leaves显示文摘 | Pu R Ge S Kell N M | 2003 | International Journal of Remote Sensing2003，24，9： | 1 |
| 6 | Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats显示文摘 | Pu F Mishima K Egashira N Akiyoshi Y Liu AX Sano K | 2005 | Am J Chin Med2005，33，3： | 1 |
| 7 | Ionic liquid as a green solvent for lignin显示文摘 | PU Y JIANG N RAGAUSKAS A J | 2007 | Wood Chem Technol2007，27，1： | 1 |
| 8 | Surface characterization of 1,3,5-triamino-2,4,6-trinitrobenzene by X-ray photoelectron spectroscopy and Fourier transform nuclear magnetic resonance显示文摘 | Pu Sen Wang Wittberg T N | 1989 | Journal of Materials Science1989，24，： | 1 |
| 9 | Climate sensitivity of the Xiao Dongkemadi glacier in the Tanggula Pass 显示文摘 | WANG N L YAO T D Pu J C | 1996 | Cryosphere1996，18，2： | 1 |
| 10 | Liquefaction of wood without a catalyst显示文摘 | SHIRAISHI N | 1993 | Mokukzai Gakkaishi1993，39，4： | 1 |
| 11 | Liquefaction of wood without a catalyst Ⅰ-Time course of wood liquefaction with phenols and effects of wood/phenol ratios 显示文摘 | PU S SHIRAISHI N | 1993 | Mokuzai Gakkaishi1993，39，4： | 1 |
| 12 | Block precondi- tioned SSOR methods for H -Matrices linear systems 显示文摘 | Pu Z N Wang X Z Lain Hak-Keung | 2013 | Journal of Applied Mathematics2013，，： | 1 |
| 13 | Liqueaction of wood without a catalyst Ⅱ-Weight loss by gasification during wood liquefaction, and effects of temperature and water 显示文摘 | PU S SHIRAISHI N | 1993 | Mokuzai Gakkaishi1993，39，4： | 1 |
| 14 | Hippocampal long- term potentiation is reduced by chronic opiate treatmentand can be restored by re- exposure to opiates 显示文摘 | Pu L Bao G B Xu N J | 2002 | J neurosci2002，22，： | 1 |
| 15 | Liqueaction of wood without a catalyst Ⅳ-Effect of an additives, such as acid, salt, and neutral oranic solvent 显示文摘 | PU S SHIRAISHI N | 1994 | Mokuzai Gakkaishi1994，40，8： | 1 |
| 16 | Invasion of human glioma cells is regulated by multiple chloride channels including clc-3 显示文摘 | LUIV C H I H LUNG SS I N S A I PU J KA N S | 2010 | Anticancer Res2010，30，11： | 1 |
| 17 | Crosstalk predic- tion of single- and double-walled carbon nanotube (SWCNT/DWCNT) bundle interconnects 显示文摘 | PU S N YIN W Y MAO J F | 2009 | IEEE Trans Electron Devices2009，56，4： | 1 |
| 18 | Acid properties and catalysis of USY zeolite with different extra-framework aluminum concentration显示文摘 | PU X LIU N Y JIANG Z H | 2015 | Microporous and Mesoporous Materials2015，201，： | 1 |
| 19 | Electron Transfer and Electrical Resistance of Nickel under High Pressure up to 42 GPa 显示文摘 | Pu F N | 1991 | Physics Letters A1991，157，23： | 1 |
| 20 | Theanine prevents memory impairment induced by repeated cerebral ischemia in rats显示文摘 | Egashira N Ishigami N Pu F | 2008 | Phytother Res2008，22，1： | 1 |
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