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| 1 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | Hollow-core antiresonant terahertz fiber-based TOPAS extruded from a 3D printer using a metal 3D printed nozzle显示文摘We report the use of a terahertz(THz)transparent material,cyclic olefin copolymer(COC or TOPAS),for fabricating a hollow-core antiresonant fiber that provides an electromagnetic wave guidance in the THz regime.A novel fabrication technique to realize a hollow-core antiresonant polymer optical fiber(HC-ARPF)for THz guidance is proposed and demonstrated.The fiber is directly extruded in a single-step procedure using a conventional fused deposition modeling 3 D printer.The fiber geometry is defined by a structured nozzle manufactured with a metal 3 D printer,which allows tailoring of the nozzle design to the various geometries of microstructured optical fibers.The possibility to use the HC-ARPF made from TOPAS for guiding in the THz region is theoretically and experimentally assessed through the profile of mode simulation and time-frequency diagram(spectrogram)analysis. | WANVISA TALATAISONG JON GORECKI LIEKE D.VAN PUTTEN RAND ISMAEEL JAMES WILLIAMSON KATIE ADDINALL DANIEL SCHWENDEMANN MARTYNAS BERESNA VASILIS APOSTOLOPOULOS GILBERTO BRAMBILLA | 2021 | Photonics Research2021，9，8： | 2 |
| 4 | Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer显示文摘 | Foekens JA Portengen H van Putten WL | 1989 | Cancer Res1989，49，： | 2 |
| 5 | Mechanisms of disease: erythropoietin resistance in patients with both heart and kidney failure显示文摘 | van der Putten K Braam B Jie KE | 2008 | Nat Clin Pract Nephrol2008，4，1： | 1 |
| 6 | Postoperative radiotherapy for stage 1 endometrial carcinoma: long-term outcome of the randomized PORTEC trial with central pathology revlew显示文摘 | Scholten AN van Putten WL Beerman H | 2005 | Int J Radiat Oncol Biol Phys2005，63，3： | 1 |
| 7 | Viewpoint:the information age in optics:measuring the transmission matrix显示文摘 | VAN PUTTEN E G MOSK A P | 2010 | Physics2010，3，： | 1 |
| 8 | Comparison of data on occupational health service, systems in Australia, Finland, Germany, TheNetherlands, Norway and Sweden显示文摘 | Draaisma D van Putten DJ Smulders PG | 1993 | Occup Med1993，43，： | 1 |
| 9 | Comparison of CHOP chemo- therapy with autologous bone marrow transplantation for slowly responding patients with aggressive non- Hodgkin s lymphoma 显示文摘 | Var Putten WLJ Hagenbeek A | 1995 | N Engl J Med1995，332，20： | 1 |
| 10 | High resolution distribution of trace elements in the calcite shell layer of modern mytilus edulis: environmental and biological controls 显示文摘 | Vander Putten E Dehairs F Keppens E | 2000 | Geochimica etCosmochimicaActa2000，64，6： | 1 |
| 11 | The morbidity of treatment for patients with stage 1 endometrial cancer:results from a randomized trial显示文摘 | Creutzberg CL van Putten WL Koper PC | 2001 | Int J Radiat Oncol Biol Phys2001，51，5： | 1 |
| 12 | Rising incidence of reflux oesophagitis in patients undergoing upper gastrointestinal endoscopy显示文摘 | Loffeld RJ van der Putten AB | 2003 | Digestion2003，68，23： | 1 |
| 13 | Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia?显示文摘 | Vellenga E van Putten WL Boogaerts MA | 1999 | Bone Marrow Transplant1999，23，12： | 1 |
| 14 | Global Gamesmanship显示文摘 | MACMILLAN I C PUTTEN A B V MCGRATH R G | 2003 | Harvard Business Review2003，81，5： | 1 |
| 15 | Inaction inertia,regret,and valuation:A closer look显示文摘 | Zeelenberg M Nijstad B.A van Putten M van Dijk E | | 0，，： | 1 |
| 16 | Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB显示文摘 | Bren-Mattison Y Meyer A M Van Putten V | | 0，，03： | 1 |
| 17 | Prognostic index for adult patients with acute myeloid leukemia in first relapse显示文摘 | Breems DA Van Putten WL Huijgens PC | | 0，，： | 1 |
| 18 | Detection of locoregional recurrent head and neck cancer after (chemo)radiotherapy using modem imaging显示文摘 | De Bree R van der Putten L Brouwer J | 2009 | Oral Oncol2009，45，： | 1 |
| 19 | Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4显示文摘 | Oertle T Huber C van der Putten H | 2003 | J Mol Biol2003，325，2： | 1 |
| 20 | High-Dose daunorubicin in older patients with acute myeloid leukemia显示文摘 | Lowenberg B Ossenkoppele GJ van Putten W | 2009 | N Engl J Med2009，361，13： | 1 |
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