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| 1 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 4 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 5 | Plant tissue-based chemiluminescence flow biosensor for urea显示文摘 | Qin W Zhang Z J Peng Y Y | 2000 | Anal Chim Acta2000，407，12： | 2 |
| 6 | Cervical Intervertebral Disc Degeneration Induced by Unbalanced Dynamic and Static Forces: A Novel In Vivo Rat Model显示文摘 | Yong-Jun Wang Qi Shi W W. Lu K C. M. Cheung Michael Darowish Tian-Fang Li Yu-Feng Dong Chong-Jian Zhou Quan Zhou Zhi-jun Hu Mei Liu Qin Bian Chen-Guang Li K D. K. Luk J C. Y. Leong | 2006 | Spine2006，，14： | 2 |
| 7 | Preparation of mesoporous carbon from commercial activated carbon with steam activation in the presence of cerium oxide显示文摘 | Shen W Z Zheng J T Qin Z F | 2003 | Journal of Colloid and Interface Science2003，264，2： | 1 |
| 8 | The electrochemical reaction of zinc oxide thin films with Lithium 显示文摘 | Huang F Qin Q Z | 2003 | J Electrochem Soc2003，150，6： | 1 |
| 9 | Mutational analysis of the structure and functions of hepatitis C virus RNA-dependent RNA polymerase显示文摘 | Yamashita T Shirota Y | 2001 | Hepatology2001，33，： | 1 |
| 10 | Disubstituted polyacetylenes containing photopolymerizable vinyl groups and polar ester functionality:Polymer synthesis,aggregation-enhanced emission,and fluorescent pattern formation显示文摘 | Wang Zhang Yuan Anjun Qin Jacky W Y Lam | 2007 | Macromolecules2007，40，9： | 1 |
| 11 | Isolation and expression analysis of fructokinase genes from Citrus显示文摘 | Qin Q P Zhang S L Chen J W | 2004 | Acta Botanica Sinica2004，46，12： | 1 |
| 12 | Micromachining of complex channel sys tems in 3D quartz substrates using Q-switched Nd: YAG laser 显示文摘 | Qin S J Li W J | 2002 | Applied Physics A2002，74，6： | 1 |
| 13 | Development and characterization of a new tropical marine fish cell line from grouper, Epinephelus coioides susceptible to iridovirus and nodavirus 显示文摘 | Qin Q W Wu T H Jia T L | 2006 | J Virol Methods2006，131，1： | 1 |
| 14 | Immunomodulatory sesquiterpene glycosides from Dendrobium nobile显示文摘 | Ye Q Qin G Zhao W | 2002 | Phytochemistry2002，61，8： | 1 |
| 15 | Electroreduction of nitrate to ammonia inalkaline solution using hydrogen storage alloy cathodes显示文摘 | C Lu S A Lu W H Qin Q G Liu | 1999 | Electrochimica Acta1999，44，： | 1 |
| 16 | Functionalization of single-walled carbon nanotubes with polystyrene via grafting to and grafting from methods显示文摘 | Qin S Qin D Ford W T | 2004 | Macromolecules2004，37，： | 1 |
| 17 | Adjoint-based optimization of a BWB shape with shock control bumps显示文摘 | Qin N Wong W S Le Moigne A | 2007 | Aeronautical Journal2007，1117，111： | 1 |
| 18 | Effects of hydrodynamics on phosphorus concentrations in water of Lake Taihu, a large, shallow, eutrophic lake of China 显示文摘 | Zhu G W Qin B Q Gao G | 2007 | Hydrobiologia2007，581，： | 1 |
| 19 | The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism 显示文摘 | Qin Y Wang J B Jun W | 2011 | J Ethnopharmacol2011，133，3： | 1 |
| 20 | Effect of Silica Sol on the Properties of Alumina-based Ceramic Core Composites显示文摘 | Qin Y X Pan W | 2009 | Materials &ience and Engineering A2009，，508： | 1 |
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