|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Solar influenced late Holocene temperature changes on the northern Tibetan Plateau显示文摘Considerable efforts have been made to extend temperature records beyond the instrumental period through proxy reconstructions,in order to further understand the mechanisms of past climate variability.Yet,the global coverage of existing temperature records is still limited,especially for some key regions like the Tibetan Plateau and for earlier times including the Medieval Warm Period(MWP).Here we present decadally-resolved,alkenone-based,temperature records from two lakes on the northern Tibetan Plateau.Characterized by marked temperature variability,our records provide evidence that temperatures during the MWP were slightly higher than the modern period in this region.Further,our temperature reconstructions,within age uncertainty,can be well correlated with solar irradiance changes,suggesting a possible link between solar forcing and natural climate variability,at least on the northern Tibetan Plateau. | HE YuXin LIU WeiGuo ZHAO Cheng WANG Zheng WANG HuanYe LIU Yi QIN XianYan HU QiHou AN ZhiSheng LIU ZhongHui | 2013 | Chinese Science Bulletin2013，58，9： | 11 |
| 2 | Nanomedicines for the treatment of rheumatoid arthritis:State of art and potential therapeutic strategies显示文摘Increasing understanding of the pathogenesis of rheumatoid arthritis(RA)has remarkably promoted the development of effective therapeutic regimens of RA.Nevertheless,the inadequate response to current therapies in a proportion of patients,the systemic toxicity accompanied by longterm administration or distribution in non-targeted sites and the comprised efficacy caused by undesirable bioavailability,are still unsettled problems lying across the full remission of RA.So far,these existing limitations have inspired comprehensive academic researches on nanomedicines for RA treatment.A variety of versatile nanocarriers with controllable physicochemical properties,tailorable drug release pattern or active targeting ability were fabricated to enhance the drug delivery efficiency in RA treatment.This review aims to provide an up-to-date progress regarding to RA treatment using nanomedicines in the last 5 years and concisely discuss the potential application of several newly emerged therapeutic strategies such as inducing the antigen-specific tolerance,pro-resolving therapy or regulating the immunometabolism for RA treatments. | Qin Wang Xianyan Qin Jiyu Fang Xun Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 4 |
| 3 | Targeting the resolution pathway of inflammation using Ac2–26 peptide-loaded PEGylated lipid nanoparticles for the remission of rheumatoid arthritis显示文摘Rheumatoid arthritis(RA)is a common autoimmune disease characterized by joint inflammation and immune dysfunction.Although various therapeutic approaches have been utilized for the treatment of RA in clinical applications,the low responsiveness of RA patients and undesired systemic toxicity are still unresolved problems.Targeting the resolution pathway of inflammation with pro-resolving mediators would evoke the protective actions of patient for combating the inflammation.Ac2–26,a 25-amino acid peptide derived from Annexin A(a pro-resolving mediator),has shown good efficacy in the treatment of inflammatory disorders.However,the low bioavailability of Ac2–26 peptides hinders their efficacy in vivo.In this paper,we formed PEGylated lipid nanoparticles(LDNPs)by the co-assembly of l-ascorbyl palmitate(L-AP)and N-(carbonyl methoxypolyethylene glycol-2000)-1,2-distearoyl-sn–glycero-3-phosphoethanolamine(DSPE-PEG 2 k)to encapsulate and deliver Ac2–26 peptides to the arthritic rats.They showed good stability and biocompatibility.After being intravenously administrated,Ac2–26 peptide-loaded PEGylated lipid nanoparticles(ADNPs)showed the prolonged in vivo circulation time and enhanced accumulation in inflamed sites.In vivo therapeutic evaluations revealed that ADNPs could attenuate synovial inflammation and improve joint pathology.Therefore,the pro-resolving therapeutic strategy using ADNPs is effective in RA treatment. | Xianyan Qin Liming He Donghao Fan Wenlang Liang Qin Wang Jiyu Fang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，4： | 3 |
| 4 | An injectable micelle-hydrogel hybrid for localized and prolonged drug delivery in the management of renal fibrosis显示文摘Localized delivery,comparing to systemic drug administration,offers a unique alternative to enhance efficacy,lower dosage,and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests.Herein,a localized drug delivery platform ('plum?pudding'structure) with controlled release and long-acting features is developed through an injectable hydrogel ('pudding') crosslinked via self-assembled triblock polymeric micelles ('plum') to help reduce renal interstitial fibrosis.This strategy achieves controlled and prolonged release of model therapeutics in the kidney for up to three weeks in mice.Following a single injection,local treatments containing either anti-inflammatory small molecule celastrol or anti-TGFb antibody effectively minimize inflammation while alleviating fibrosis via inhibiting NF-k B signaling pathway or neutralizing TGF-b1 locally.Importantly,the micelle-hydrogel hybrid based localized therapy shows enhanced efficacy without local or systemic toxicity,which may represent a clinically relevant delivery platform in the management of renal interstitial fibrosis. | Xianyan Qin Yingying Xu Xu Zhou Tao Gong Zhi-Rong Zhang Yao Fu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 2 |
| 5 | Analysis of phosphorus forms in sediment cores from ephemeral ponds on Ardley Island, West Antarctica显示文摘The guano of penguins, other seabirds, and pinnipeds is an important source of phosphorus in the ecosystems of Antarctica. To study the vertical distribution of phosphorus in sediments influenced by penguins, we measured phosphorus forms in two sediment cores(G1 and Q2) from ephemeral ponds on Ardley Island. We also investigated the correlations between these phosphorus forms and physicochemical characteristics. Inorganic phosphorus was the main form of phosphorus in both cores. The vertical distribution patterns of phosphorus forms in G1 and Q2 differed, indicating different sedimentary sources. The G1 sediment profile was more influenced by penguin guano than the Q2 profile, and as a result sediments in the G1 core had higher total phosphorus, non-apatite inorganic phosphorus, and apatite phosphorus content. The findings from two ephemeral ponds on Ardley Island indicate that the contribution of penguin guano to organic matter in G1 core has increased in recent times, while Q2 showed a relatively larger contribution from mosses in ancient times, evident from the lithology and the vertical trend in organic matter. | YANG Lianjiao QIN Xianyan SUN Liguang HUANG Tao WANG Yuhong | 2015 | Advances in Polar Science2015，26，1： | 1 |
| 6 | Failure Mechanisms and Structural Optimization of Shredder Hammer for Metal Scraps显示文摘Recycling retired cars can relieve the environmental pollution and resource waste efficiently.However,a few publications can be found on the failure mechanisms and optimization method of recycling equipment,shredders.Thus,the failure mechanisms and structural optimization of shredder hammers for retired cars are studied aiming improving shredding efficiency and reducing cost.Failure types of shredder hammer are studied theoretically,and it is found that wear failure and fatigue failure are the two main failure types of shredder hammer.The shredding process of metal scraps is analyzed by finite element method,and it can be divided into four stages based on the stress states:initial stage,collision stage,grinding stage and separation stage.It is proved that the shredding efficiency can be improved by increasing cutouts on the hammer head.Finally,it is determined that the hammer with two cutouts is the optimal structure for metal scraps,which can improve the shredding efficiency by 20% and lengthen the hammer life by 15%.This study provides scientific basis for the industry application and theoretical foundation for further research. | ZHOU Xianyan HU Zhili TAO Yijun QIN Xunpeng HUA Lin | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员