|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combined genomic, transcriptomic, and metabolomic an alyses provide in sights into chayote (Sechium edule) evolution and fruit development显示文摘Chayote(Sechium edule)is an agricultural crop in the Cucurbitaceae family that is rich in bioactive components.To enhance genetic research on chayote,we used Nanopore third-generation sequencing combined with Hi-C data to assemble a draft chayote genome.A chromosome-level assembly anchored on 14 chromosomes(N50 contig and scaffold sizes of 8.40 and 46.56 Mb,respectively)estimated the genome size as 606.42 Mb,which is large for the Cucurbitaceae,with 65.94%(401.08 Mb)ofthe genome comprising repetitive sequences;28,237 protein-coding genes were predicted.Comparative genome analysis indicated that chayote and snake gourd diverged from sponge gourd and that a whole-genome duplication(WGD)event occurred in chayote at 25±4 Mya.Transcriptional and metabolic analysis revealed genes involved in fruit texture,pigment,fl avor,fl avonoids,antioxidants,and plant hormones during chayote fruit development.The analysis of the genome,transcriptome,and metabolome provides insights into chayote evolution and lays the groundwork for future research on fruit and tuber development and genetic improvements in chayote. | Anzhen Fu Qing Wang Jianlou Mu Lili Ma Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuechuan Zhang Xuewen Zhang Fengling Wang Donald Grierson Jinhua Zuo | 2021 | Horticulture Research2021，8，1： | 6 |
| 2 | Direct Triflylation of Benzylic C-H Bonds with Pyridine as a Directing Group显示文摘 | Jun Yang Juanjuan Hu Yangen Huang Xiuhua Xu Fengling Qing | 2017 | Chinese Journal of Chemistry2017，35，6： | 3 |
| 3 | Synthesis and Antitumor Activity Evaluation of γ-Monofluorinated and γγy-Difluorinated Goniothalamin Analogues显示文摘一系列小说, -difluorinated Goniothalamin 类似物 4a4i 和 6a6i 被综合。关键步通过脂肪分解酵素 AK 包括了邻近 gem-difluoromethylene 组的 C-5 stereocenter 的构造催化运动分辨率,经由联合的 Stille 的芳基组的介绍,和由 1,5-oxidative 的 lactonization 环合。这些, -difluorinated Goniothalamin 类似物 4a4i 和他们的 enantiomers 6a6i,和几相应 -monofluorinated Goniothalamin,类似物生物学上与四根不同癌症房间线被作比较。复合 7h 在 micromolar 范围作为父母(R)-Goniothalamin 显示出将近相等的力量。在在 antitumor 活动的 fluoromethylene 和 gem-difluoromethylene 之间的不同氟的符号效果通过生物鉴定数据的分析被讨论。 | Yi Yang Zhenjun Yang Chunru Cheng Fengling Qing | 2013 | Chinese Journal of Chemistry2013，31，6： | 2 |
| 4 | Synthesis and repellent properties of vinylidene fluoride- containing polyacrylates 显示文摘 | HUANG Jiqing MENG Weidong QING Fengling | 2007 | Journal of Fluorine Chemistry2007，128，2： | 1 |
| 5 | Synthesisand surface antimicrobial activity of a novel perfluorooctylated quater-nary ammonium silane coupling agent 显示文摘 | SHAO HUI MENG WEIDONG QING FENGLING | 2004 | Journal of FluorineChemistry2004，125，： | 1 |
| 6 | Synthesis and repellentproperties of vinylidene fluoride-containing polyacrylates显示文摘 | Jiqing Huang Weidong Mengt Fengling Qing | 2007 | Journalof Fluorine Chemistry2007，128，： | 1 |
| 7 | Syn- thesis of a novel perfluorooctylated polyacrylate and itsapplication on cotton {abrics显示文摘 | Jiang Wanchao Meng Weidong Qing Fengling | 2005 | Journal o{ Applied Pol- ymer Science2005，98，1： | 1 |
| 8 | Synthesis of perfluoroalkyl-containing multifunctional groups compounds for textile finishing显示文摘 | Qing Fengling Ji Min Lu Ronghua | 2002 | Journal of Fluorine Chemistry2002，，： | 1 |
| 9 | Synthesis and surface antimicrobial activity of a novel perfluorooctylated quaternary ammonium silane coupling agent显示文摘 | Shao Hui Meng Weidong Qing Fengling | 2004 | Journal of Fluorine Chemistry2004，125，： | 1 |
| 10 | Synthesis of a novel perfluorooctylated polyacrylate and its application on cotton fabrics 显示文摘 | Jiang Wanchao Meng Weidong Qing Fengling | 2005 | Journal of Applied Polymer Science2005，98，1： | 1 |
| 11 | Synthesis of a novel perfluorooctylated polyacrylate and its application on cotton fabrics 显示文摘 | Jiang Wanchao Meng Weidong Qing Fengling | 2005 | Journal of Applied Polymer Science2005，98，1： | 1 |
| 12 | Synthesis of a novel perfluorooctylated polyacrylate and its application on cotton fabrics 显示文摘 | Jiang Wanchao Meng Weidong Qing Fengling | 2005 | Journal of Applied Polymer Science2005，98，1： | 1 |
| 13 | Synthesis and repellent properties of vinylidene fluoride-containing polyacrylates显示文摘 | Huang Jiqing Meng Weidong Qing Fengling | 2007 | Journal of Fluorine Chemistry2007，128，： | 1 |
| 14 | Synthesis of a novel perfluorooctylated polyacrylate and its application on cotton fabrics显示文摘 | Jiang Wanchao Meng Weidong Qing Fengling | 2005 | Journal of Applied Polymer Science2005，98，1： | 1 |
| 15 | Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma显示文摘Neuroblastoma(NB),which is the most common pediatric extracranial solid tumor,varies widely in its clinical presentation and outcome.NB has a unique ability to spontaneously differentiate and regress,suggesting a potential direction for therapeutic intervention.However,the underlying mechanisms of regression remain largely unknown,and more reliable prognostic biomarkers are needed for predicting trajectories for NB.We performed scRNAseq analysis on 17 NB clinical samples and three peritumoral adrenal tissues.Primary NB displayed varied cell constitution,even among tumors of the same pathological subtype.Copy number variation patterns suggested that neuroendocrine cells represent the malignant cell type.Based on the differential expression of sets of related marker genes,a subgroup of neuroendocrine cells was identified and projected to differentiate into a subcluster of benign fibroblasts with highly expressed CCL2 and ZFP36,supporting a progressive pathway of spontaneous NB regression.We also identified prognostic markers(STMN2,TUBA1A,PAGE5,and ETV1)by evaluating intra-tumoral heterogeneity.Lastly,we determined that ITGB1 in M2-like macrophages was associated with favorable prognosis and may serve as a potential diagnostic marker and therapeutic target.In conclusion,our findings reveal novel mechanisms underlying regression and potential prognostic markers and therapeutic targets of NB. | Qingqing Liu Zhenni Wang Yan Jiang Fengling Shao Yue Ma Mingzhao Zhu Qing Luo Yang Bi Lijian Cao Liang Peng Jianwu Zhou Zhenzhen Zhao Xiaobin Deng Tong-Chuan He Shan Wang | 2022 | Genes & Diseases2022，9，6： | 0 |
| 16 | Iron-catalyzed cyanoalkylation of difluoroenol silyl ethers with cyclobutanone oxime esters显示文摘An iron-catalyzed coupling reaction of difluoroenol silyl ethers and cyclobutanone oxime esters is described. This protocol provides a convenient access to various previously unknown and potentially useful gem-difluoromethylenated ketonitriles inmoderate to good yields. The transformations of resulting products to other fluorinecontaining products is also documented. | Xiaolei Zhu Yangen Huang Xiuhua Xu Fengling Qing | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员