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| 1 | D(β)-vertex-distinguishing total coloring of graphs显示文摘A new concept of the D(β)-vertex-distinguishing total coloring of graphs, i.e., the proper total coloring such that any two vertices whose distance is not larger than β have different color sets, where the color set of a vertex is the set composed of all colors of the vertex and the edges incident to it, is proposed in this paper. The D(2)-vertex-distinguishing total colorings of some special graphs are discussed, meanwhile, a conjecture and an open problem are presented. | ZHANG Zhongfu,LI Jingwen,CHEN Xiang’en,YAO Bing, WANG Wenjie & QIU Pengxiang Institute of Applied Mathematic, Lanzhou Jiaotong University, Lanzhou 730070, China College of Mathematics and Information Science, Northwest Normal University, Lanzhou 730070, China College of Information and Electrical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China | 2006 | Science China Mathematics2006，49，10： | 54 |
| 2 | Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer显示文摘Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional drugs.The purpose of this study was to search for such predictors.Methods:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer patients.Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice.Bioluminescence imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune cells.Results:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral blood.Levels of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after chemotherapy.Moreover,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte recovery.Conclusions:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sensitive to second-generation agents such as SHR-1701. | Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu | 2022 | Cancer Communications2022，42，1： | 5 |
| 3 | Vertex-distinguishing total colorings of graphs显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 4 | Vertex-distinguishing total coloring of graphs 显示文摘 | Zhang Zhongfu Qiu Pengxiang Xu Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 5 | Vertexdistinguishing total coloring of graphs 显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 6 | vertex-distinguishing total colorings of graphs 显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 7 | verter - dis- tinguishing total colourings of graphs 显示文摘 | ZHANG zhongfu QIU Pengxiang XU Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 8 | Vertex-distinguishing total colorings of graphs 显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 9 | Vertex-distinguishing total colorings of graphs 显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 10 | Vertex distinguishing total coloring of graphs显示文摘 | Zhang Zhongfu Qiu Pengxiang Xu Baogen | 2008 | Ars Combina- toria2008，87，： | 1 |
| 11 | Vertex Distinguishing Total Coloring of Graphs显示文摘 | Zhang Zhongfu Qiu Pengxiang Xu Baoen | 2008 | Ars Combinatoria2008，87，： | 1 |
| 12 | Ver- tex- diainguishing total coloring of graphs 显示文摘 | Zhang Zhongfu Qiu Pengxiang Xu Baogen | 2008 | Ars Comb2008，87，： | 1 |
| 13 | Vertex-distinguishing total coloring of graphs显示文摘 | Zhang Zhongfu Qiu Pengxiang Xu Baogen etal | 2008 | Ars Combinatoria2008，87，： | 1 |
| 14 | Vertex-distinguishing total coloring of graphs显示文摘 | Zhang Zhongfu Pengxiang Qiu Baogen Xu etc | 2008 | Ars Combinatoria2008，，87： | 1 |
| 15 | Vertex Distinguishing Total Colorings of Graphs 显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | ArsCombinatorial2008，87，： | 1 |
| 16 | vertex-distinguishing total colorings of graphs显示文摘 | Zhongfu Zhang Pengxiang Qiu Baogen Xu | 2008 | Ars Combinatoria2008，，87： | 1 |
| 17 | Vertex-distinguishing total coloring of graphs显示文摘 | ZHANG Zhongfu QIU Pengxiang XU Baogen | 2008 | ArsCombinatoria2008，87，： | 1 |
| 18 | Vertex-distinguishing total coloring of graphs显示文摘 | Zhongfu Zhang Pengxiang Qiu Baogen Xu etc | 2008 | Ars Combinatoria2008，，87： | 1 |
| 19 | On the double and complement double graph of the graph显示文摘 | Zhongfu Zhang Pengxiang Qiu Donghan Zhang | 2008 | Adances in Mathematics to paper2008，37，3： | 1 |
| 20 | Vertex-distinguishing total coloring of graphs显示文摘 | Zhang Zhongfu Qiu Pengxiang Xu Baogen et 01 | 2008 | ARS Combinatoria2008，87，： | 1 |
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