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| 1 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 2 | Mechanical activation of spike fosters SARS-CoV-2 viral infection显示文摘The outbreak of SARS-CoV-2(SARS2)has caused a global COVID-19 pandemic.The spike protein of SARS2(SARS2-S)recognizes host receptors,including ACE2,to initiate viral entry in a complex biomechanical environment.Here,we reveal that tensile force,generated by bending of the host cell membrane,strengthens spike recognition of ACE2 and accelerates the detachment of spike’s S1 subunit from the S2 subunit to rapidly prime the viral fusion machinery.Mechanistically,such mechano-activation is fulfilled by force-induced opening and rotation of spike’s receptor-binding domain to prolong the bond lifetime of spike/ACE2 binding,up to 4 times longer than that of SARS-S binding with ACE2 under 10 pN force application,and subsequently by force-accelerated S1/S2 detachment which is up to~103 times faster than that in the no-force condition.Interestingly,the SARS2-S D614G mutant,a more infectious variant,shows 3-time stronger force-dependent ACE2 binding and 35-time faster force-induced S1/S2 detachment.We also reveal that an anti-S1/S2 non-RBD-blocking antibody that was derived from convalescent COVID-19 patients with potent neutralizing capability can reduce S1/S2 detachment by 3×106 times under force.Our study sheds light on the mechano-chemistry of spike activation and on developing a non-RBD-blocking but S1/S2-locking therapeutic strategy to prevent SARS2 invasion. | Wei Hu Yong Zhang Panyu Fei Tongtong Zhang Danmei Yao Yufei Gao Jia Liu Hui Chen Qiao Lu Tenny Mudianto Xinrui Zhang Chuxuan Xiao Yang Ye Qiming Sun Jing Zhang Qi Xie Pei-Hui Wang Jun Wang Zhenhai Li Jizhong Lou Wei Chen | 2021 | Cell Research2021，31，10： | 2 |
| 3 | Complex-amplitude radiation-type metasurface enabling beamform-controlled energy allocation显示文摘Fifth-generation(5G)communication requires spatial multiplexing multiple-input multiple-output systems with integrated hardware.With the increase in the number of users and emergence of the Internet of Things devices,complex beamforming devices have become particularly important in future wireless systems to meet different communication requirements,where independent amplitude and phase modulations are urgently required for integrated beamforming devices.Herein,by utilizing the constructive interference between multiple geometricphase responses,the mathematical relation for decoupling amplitude and phase modulations in the radiation-type operational mode is derived.Based on this strategy,complex-amplitude radiation-type metasurfaces(RA-Ms)are implemented,with an integrated feeding network.Such metasurfaces exploit full 2πphase modulation and tailorable radiation amplitude in the circular polarization state.Meanwhile,a complex-amplitude retrieval method is developed to design the RA-Ms,enabling precise beamforming performances.On this basis,several functional devices based on the complex-amplitude RA-Ms,including energy-allocable multi-router,shape-editable beam generator,and complex beamformer,are demonstrated in the microwave region.The amplitude-phase decoupling mechanism with the retrieval method merges amplitude and phase modulations,and energy distribution into one compact and integrated electromagnetic component and may find applications in multi-target detection,5G mobile communication,and short-range ground-to-sea radar. | YONGHENG MU CHENG PANG YUZHONG WANG QIMING WANG JIARAN QI | 2023 | Photonics Research2023，11，6： | 1 |
| 4 | Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway.显示文摘 | Jinmei Li Lili Ding Baoliang Song Xu Xiao Meng Qi Qiaoling Yang Qiming Yang Xiaowen Tang Zhengtao Wang Li Yang | 2015 | European Journal of Pharmacology2015，，： | 1 |
| 5 | Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice显示文摘Increasing the osteogenic differentiation ability and decreasing the adipogenic differentiation ability of bone marrow mesenchymal stem cells(BMSCs)is a potential strategy for the treatment of osteoporosis(OP).Naturally derived oligosaccharides have shown significant anti-osteoporotic effects.Nystose(NST),an oligosaccharide,was isolated from the roots of Morinda officinalis How.(MO).The aim of the present study was to investigate the effects of NST on bone loss in ovariectomized mice,and explore the underlying mechanism of NST in promoting differentiation of BMSCs to osteoblasts.Administration of NST(40,80 and 160 mg/kg)and the positive control of estradiol valerate(0.2 mg/kg)for 8 weeks significantly prevented bone loss induced by ovariectomy(OVX),increased the bone mass density(BMD),improved the bone microarchitecture and reduced urine calcium and deoxypyridinoline(DPD)in ovariectomized mice,while inhibited the increase of body weight without significantly affecting the uterus weight.Furthermore,we found that NST increased osteogenic differentiation,inhibited adipogenic differentiation of BMSCs in vitro,and upregulated the expression of the key proteins of BMP and Wnt/β-catenin pathways.In addition,Noggin and Dickkopf-related protein-1(DKK-1)reversed the effect of NST on osteogenic differentiation and expression of the key proteins in BMP and Wnt/β-catenin pathway.The luciferase activities and the molecular docking analysis further supported the mechanism of NST.In conclusion,these results indicating that NST can be clinically used as a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis. | Qi Zhang Sijing Hu Jianjun Wu Peng Sun Quanlong Zhang Yang Wang Qiming Zhao Ting Han Luping Qin Qiaoyan Zhang | 2023 | Food Science and Human Wellness2023，12，2： | 1 |
| 6 | PbrChiA:a key chitinase of pear in response to Botryosphaeria dothidea infection by interacting with PbrLYK1b2 and down-regulating ROS accumulation显示文摘Pear ring rot,caused by the pathogenic fungi Botryosphaeria dothidea,seriously affects pear production.While the infection-induced reactive oxygen species(ROS)burst of infected plants limits the proliferation of B.dothidea during the early infection stage,high ROS levels can also contribute to their growth during the later necrotrophic infection stage.Therefore,it is important to understand how plants balance ROS levels and resistance to pathogenic B.dothidea during the later stage.In this study,we identified PbrChiA,a glycosyl hydrolases 18(GH18)chitinase-encoding gene with high infection-induced expression,through a comparative transcriptome analysis.Artificial substitution,stable overexpression,and virus induced gene silencing(VIGS)experiments demonstrated that PbrChiA can positively regulate pear resistance as a secreted chitinase to break down B.dothidea mycelium in vitro and that overexpression of PbrChiA suppressed infection-induced ROS accumulation.Further analysis revealed that PbrChiA can bind to the ectodomain of PbrLYK1b2,and this interaction suppressed PbrLYK1b2-mediated chitin-induced ROS accumulation.Collectively,we propose that the combination of higher antifungal activity from abundant PbrChiA and lower ROS levels during later necrotrophic infection stage confer resistance of pear against B.dothidea. | Qiming Chen Huizhen Dong Qionghou Li Xun Sun Xin Qiao Hao Yin Zhihua Xie Kaijie Qi Xiaosan Huang Shaoling Zhang | 2023 | Horticulture Research2023，10，10： | 0 |
| 7 | Author Correction: Mechanical activation of spike fosters SARS- CoV-2 infection显示文摘 | Wei Hu Yong Zhang Panyu Fei Tongtong Zhang Danmei Yao Yufei Gao Jia Liu Hui Chen Qiao Lu Tenny Mudianto Xinrui Zhang Chuxuan Xiao Yang Ye Qiming Sun Jing Zhang Qi Xie Pei-Hui Wang Jun Wang Zhenhai Li Jizhong Lou Wei Chen | 2021 | Cell Research2021，31，11： | 0 |
| 8 | Multi-aperture optical imaging systems and their mathematical light field acquisition models显示文摘Inspired by the compound eyes of insects,many multi-aperture optical imaging systems have been proposed to improve the imaging quality,e.g.,to yield a high-resolution image or an image with a large field-ofview.Previous research has reviewed existing multi-aperture optical imaging systems,but few papers emphasize the light field acquisition model which is essential to bridge the gap between configuration design and application.In this paper,we review typical multi-aperture optical imaging systems(i.e.,artificial compound eye,light field camera,and camera array),and then summarize general mathematical light field acquisition models for different configurations.These mathematical models provide methods for calculating the key indexes of a specific multiaperture optical imaging system,such as the field-of-view and sub-image overlap ratio.The mathematical tools simplify the quantitative design and evaluation of imaging systems for researchers. | Qiming QI Ruigang FU Zhengzheng SHAO Ping WANG Hongqi FAN | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，6： | 0 |
| 9 | A flexible solid polymer electrolyte enabled with lithiated zeolite for high performance lithium battery显示文摘Solid-state lithium batteries using composite polymer electrolytes(CPEs)have attracted much attention owing to their higher safety compared to liquid electrolytes and flexibility compared to ceramic electrolytes.However,their unsatisfactory lithium-ion conductivity still limits their development.Herein,a high ion conductive CPE with multiple continuous lithium pathways is designed.This new electrolyte consists of poly(vinylidene fluorideco-hexafluoropropylene)(PVDF-HFP)and lithiated X type zeolite(Li-X),which possesses a high ionic conductivity(1.98×10^(-4)S/cm),high lithium transference number(t_(Li^(+))=0.55),wide electrochemical window(4.7 V),and excellent stability against the lithium anode.Density functional theory(DFT)calculation confirms that the Lewis acid sites in zeolite can graft with N,N-dimethylformamide(DMF)and PVDF-HFP chains,resulting in decreased crystallinity of polymer and providing rapid Li+transmission channels.When used in a full cell,the solid Li|Li-X-3%|LiFePO_(4) cell displays excellent cycling stability and rate performance at room temperature and 60℃.Furthermore,pouch cells with the Li-X-3%electrolyte exhibit brilliant safety under extreme conditions,such as folding and cutting.Thus,this proposed zeolite-PVDF-HFP CPE represents a promising potential in the application of making a safer,higher performing,and flexible solid-state lithium battery. | Zhiyu Ding Qiming Tang Qi Zhang Penghui Yao Xingjun Liu Junwei Wu | 2023 | Nano Research2023，16，7： | 0 |
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