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| 1 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 2 | Synthesizing and bind- ing dual-mode poly ( lactic-co-glycolic acid) (PLGA) nanobubbles for cancer targeting and imaging显示文摘 | Xu JS Huang JW Qin RG | 2010 | Bioma- terials2010，31，14： | 1 |
| 3 | Measure and Analysis of dominant wood populations niche in nature secondary forest in east mountains of northeast of China显示文摘 | Li DZ Qin AL Zang RG | 1995 | Quarterly of Chinese Forestry1995，28，2： | 1 |
| 4 | Effects of forest canopy density and epixylic vegetation on nutrient concentrations in decaying logs of a subalpine fir forest显示文摘Background:Deadwood and the associated epixylic vegetation influence nutrient cycles in forest ecosystems.Open canopies strongly regulate deadwood decomposition and disrupt epixylic vegetation on logs.However,it is unclear how the forest canopy density and epixylic vegetation growth affect the nutrient concentrations in deadwood.Methods:We measured the concentrations of nitrogen(N),phosphorus(P),potassium(K),calcium(Ca),sodium(Na),magnesium(Mg),and manganese(Mn)in experimentally exposed decaying logs placed in gaps,at the edge of gaps,and under the closed canopy during a four-year decomposition experiment in a Subalpine Faxon fir forest(Abies fargesii var.faxoniana)on the eastern Qinghai-Tibetan Plateau,China.To assess the effect of the epixylic vegetation,we experimentally removed it from half of the logs used in the study.Results:Under open canopy conditions in the gap and at the edge,the concentrations for most of the nutrients in the bark and the highly decayed wood were lower than under the closed canopy.The effect of the epixylic treatment on nutrient concentrations for all but K and Na in barks varied with the decay classes.Significantly lower concentrations of N,P,Ca,and Mn following the removal of epixylic vegetation were observed in the wood of decay class IV.Epixylic vegetation significantly increased most nutrient concentrations for decaying barks and wood under open canopy conditions.In contrast,epixylic vegetation had no or minimal effects under the closed canopy.Conclusions:Forest canopy density and epixylic vegetation significantly alter the nutrient concentrations in decaying logs.Open canopies likely accelerate the rate of nutrient cycling between the epixylic vegetation and decaying logs in subalpine forests. | Zhuang Wang Wanqin Yang Bo Tan Qin Wang Lifeng Wang Chenhui Chang Rui Cao Yurui Jiang Jörg Müller | 2022 | Forest Ecosystems2022，9，5： | 0 |
| 5 | Tough PEG-only hydrogels with complex 3D structure enabled by digital light processing of“all-PEG”resins显示文摘Digital light processing(DLP)of structurally complex poly(ethylene glycol)(PEG)hydrogels with high mechanical toughness represents a long-standing challenge in thefield of 3D printing.Here,we report a 3D printing approach for the high-resolution manufacturing of structurally complex and mechanically strong PEG hydrogels via heat-assisted DLP.Instead of using aqueous solutions of photo-crosslinkable monomers,PEG macromonomer melts werefirst printed in the absence of water,resulting in bulk PEG networks.Then,post-printing swelling of the printed networks was achieved in water,producing high-fidelity 3D hydrogels with complex structures.By employing a dual-macromonomer resin containing a PEG-based four-arm macrophotoinitiator,“all-PEG”hydrogel constructs were pro-duced with compressive toughness up to 1.3 MJ m^(-3).By this approach,porous 3D hydrogel scaffolds with trabecular-like architecture were fabricated,and the scaf-fold surface supported cell attachment and the formation of a monolayer mimicking bone-lining cells.This study highlights the promises of heat-assisted DLP of PEG photopolymers for hydrogel fabrication,which may accelerate the development of 3D tissue-like constructs for regenerative medicine. | Safira Noor Anindita Riccardo Conti Doris Zauchner Nevena Paunovi´c Wanwan Qiu Marina Green Buzhor Adva Krivitsky Zhi Luo Ralph Müller Hansjörg Grützmacher Xiao-Hua Qin Jean-Christophe Leroux Yinyin Bao | 2023 | Aggregate2023，4，6： | 0 |
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