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您的检索式：作者名="Qinda Chen"
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| 1 | Indocyanine green-/TLR7 agonist-constructed thermosensitive liposome for low-temperature PTT induced synergistic immunotherapy of colorectal cancer显示文摘Colorectal cancer(CRC)is a lethal malignancy with a high mortality rate due to its low immunogenicity,the strong immunosuppressive milieu and poor drug permeability.To overcome these obstacles,a cascade synergistic nanosystem(denoted as R837/ICG@Lip)was developed via self-assembly of heater indocyanine green(ICG)and toll-like receptor-7 agonist imiquimod(R837)into thermosensitive liposome for simultaneous induction of immunogenic cell death(ICD)and reversing of suppressive tumor microenvironment.The obtained nanoparticles exhibited NIR-triggered drug release,good photothermal conversion efficiency and phototoxicity towards CT26 colorectal cancer cells.In vivo results reveal that the R837/ICG@Lip could be effectively accumulated in CT26 subcutaneous tumors and the draining lymph nodes.More importantly,R837/ICG@Lip-mediated low-temperature photothermal therapy triggers ICD,promotes the maturation of host dendritic cells(DCs),and subsequently amplifies adaptive antitumor T-cell responses,resulting in‘Cold to Hot'transition.Besides directly affecting immune cells,the secretion of some immune-related cytokines further indirectly boosted anti-cancer immunity.After combining with the indoleamine 2,3-dioxygenase(IDO)inhibitor,the systemic antitumor immune response was further augmented,achieving best tumor inhibition effects.Thus,low-temperature mediated photoimmunotherapy targeting multiple antitumor immune pathways boost synergistic antitumor immunity of tolerance tumors. | Xiang Sun Yanmin Wang Tao Du Qiang Zhang Shuo Li Qinda Chen Miao Wang Xiumin Wang Lei Ren Xueqin Zhao | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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