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| 1 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 2 | Development of a Novel Kilowatt Microwave Plasma Torch Source for Atomic Emission Spectrometry显示文摘 | ZHU Dan JIN Wei YU Bingwen YING Yangwei YU Haixiang SHAN Jin YAN Yuwei XU Chen WANG Baolai JIN Qinhan | 2017 | Chemical Research in Chinese Universities2017，33，5： | 1 |
| 3 | Grey Correlation Method in the Decision of Bridge Design Plans显示文摘 | HAO ZHAN CHEN WEIZHEN FANG QINHAN | 2009 | Kybemetes2009，38，10： | 1 |
| 4 | Microwave- assisted extraction of effective constituents from a Chinese herbal medicine Radix puerariae 显示文摘 | Zhenku Guo Qinhan Jin Guoqiang Fan | 2001 | Analytica Chimica t Acta2001，436，： | 1 |
| 5 | Microwave-assisted extraction of effective constituents from a Chinese herbal medicine radix puerariae显示文摘 | Guo Zhenku Jin Qinhan Fan Guoqiang | 2001 | Analytica Chimica Acta2001，436，： | 1 |
| 6 | Use of microwave plasma torch atomic emission spectrometry for the determination of silicon显示文摘 | Feng Liang Hanqi Zhang Qun Jin Daxin Zhang Yahu Lei Qinhan Jin | 1997 | Fresenius Journal of Analytical Chemistry1997，，4： | 1 |
| 7 | A Study on Microwave Induced Plasma Ionization Detector for Gas Chromatograph显示文摘Among various ionization detectors for gas chromatography(GC), the most promising one is perhaps the nonradioactive ionization detector which makes use of a microwave induced plasma(MIP). The use of MIP for gas chromatography was first studied by McCormack, et al. in 1965, Freeman developed a photoionization detector utilizing helium microwave discharge. In 1971, we developed a | Yu Aimin, Xu Wenguo, Wang Fendi, Wang Xu, Liu Yun and Jin Qinhan (Department of Chemistry, Jilin University, Changchun) | 1991 | Chemical Research in Chinese Universities1991，7，4： | 1 |
| 8 | A Microwave plasma torchassembly for atomic emissionspectrometry显示文摘 | Qinhan Jin Chu Zhu Matthew W | 1991 | Spectrochimica Acta(B)1991，46，3： | 1 |
| 9 | Microwave assisted extract ion of effective const ituents from a chinese herbal medicine radix puerariae显示文摘 | Zhenku Guo Qinhan Jin Guoqiang Fan | 2001 | Analyt ica Chimica Acta2001，436，： | 1 |
| 10 | Microwave-assisted extraction of effective constituents from a Chinese herbal medicine Radix puerariae显示文摘 | Zhenku Guo Qinhan Jin Guoqiang Fan Yuping Duan Chen Qin Minjie Wen | 2001 | Analytica Chimica Acta2001，，1： | 1 |
| 11 | Study of atmospheric pressure microwave plasma spectrometry显示文摘 | Jin Qinhan Yang Guangde Yu Aimin | 1985 | Acta Scientiarum Naturalium Universitatis Jilinensis1985，，1： | 1 |
| 12 | Application of microwave techniquesin analytical chemistry显示文摘 | Qinhan Jin Feng Liang Hanqi Zhang | 1999 | Trends in Analytical Chemistry1999，18，： | 1 |
| 13 | Study on Prestressed Transfer Efficiency and Moment Amplitude Modulation of Steel-Concrete Composite Bridge显示文摘 | Li Yong Fang Qinhan Zhu Hongping | 2011 | Journal of Harbin Institute of Technology2011，，2： | 1 |
| 14 | Apptication of Mierowave Techniques in Analytical Chemistry显示文摘 | JIN Qinhan LIANG Feng ZHANG Hanqi | 1999 | Trends in Analytical Chemistry1999，18，7： | 1 |
| 15 | Electromagnetic Properties of a New Microwave Plasma Torch with Double Resonance Configuration显示文摘 | YU Bingwen JIN Wei ZHU Dan YING Yangwei YU Haixiang SHAN Jin XU Chen LIU Wenlong JIN Qinhan | 2016 | Chemical Research in Chinese Universities2016，32，4： | 1 |
| 16 | Microwave-Assisted Extraction of Effective Constituents from a Chinese Herbal Medicine Radix Puerariae显示文摘 | Zhenku Guo Qinhan Jin Guoqiang Fan | 2001 | Analytica Chimica Acta2001，436，： | 1 |
| 17 | Application of microwave techniques in analytical chemistry显示文摘 | Jin Qinhan Liang Feng Zhang Hanqi | 1999 | Trends in Analytical Chemistry1999，18，7： | 1 |
| 18 | Application of microwave techniques in analytical chemistry显示文摘 | Qinhan Jin Feng Liang Hanqi Zhang | 1999 | Trends in Analytical Chemistry1999，18，： | 1 |
| 19 | Evaluation of Atomic Fluorescence Spectrometry for Determination of Mercury Using a Low-Powered Argon Microwave Plasma Torch (MPT)显示文摘The Microwave-Induced Plasma (MIP) has received considerable attention during the past decade since theintroduction of the Becnakker Cavity. It has been commonly used as an atomization cell for atomic emission spectrometry (AES) and atomic absorption spectrometry (AAS), and a great success was achieved for both techniques. | Duan Yixiang, Kong Xiangxing, Zhang Hanqi, Liu Jun Jin Qinhan (Department of Chemistry, Jilin University, Changchun) | 1991 | Chemical Research in Chinese Universities1991，7，1： | 0 |
| 20 | Reactive air wetting and brazing of Al_(2)O_(3) ceramics using Ag-Nb_(2)O_(5) filler: Performance and interfacial behavior显示文摘We firstly performed the reactive air wetting and brazing of Al_(2)O_(3) ceramics using Ag-(0.5-12)Nb_(2)O_(5) fillers,where Nb_(2)O_(5) can react with liquid Ag and O2 from air to generate AgNbO_(3).The contact angle of the Ag-Nb_(2)O_(5)/Al_(2)O_(3) system almost linearly decreases from~71.6°to 32.5°with the Nb_(2)O_(5) content increasing,and the joint shear strength reaches the maximum of~65.1 MPa while employing the Ag-4Nb_(2)O_(5) filler,which are mainly related to the formation and distribution of the AgNbO_(3) phase at the interface.Moreover,the interfacial bonding and electronic properties of related interfaces were investigated by first-principles calculations.The calculated works of adhesion(Wa)of Ag(111)/Ag-O-AgNbO_(3)(001)and AgNbO_(3)(001)/Al_(2)O_(3)(100)interfaces are higher than that of the Ag(111)/Al_(2)O_(3)(110)interface,indicating good reliability of the Ag/AgNbO_(3)/Al_(2)O_(3) structure.The relatively large interfacial charge transfer indicates the formation of Ag-Ag,Al-O,and Ag-O bonds in the Ag/AgNbO_(3)/Al_(2)O_(3) structure,which can contribute to the interfacial bonding. | Yudi Qiu Shunjian Xu Xiangzhao Zhang Mingfen Zhang Qinhan Guo Beiji Wang Guanjun Qiao Guiwu Liu | 2024 | Journal of Advanced Ceramics2024，13，2： | 0 |
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