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| 1 | An octamer of enolase from Streptococcus suis显示文摘Enolase is a conserved cytoplasmic metalloenzyme existing universally in both eukaryotic and prokaryotic cells.The enzyme can also locate on the cell surface and bind to plasminogen,via which contributing to the mucosal surface localization of the bacterial pathogens and assisting the invasion into the host cells.The functions of the eukaryotic enzymes on the cell surface expression(including T cells,B cells,neutrophils,monocytoes,neuronal cells and epithelial cells)are not known.Streptococcus suis serotype 2(S.suis 2,SS2)is an important zoonotic pathogen which has recently caused two large-scale outbreaks in southern China with severe streptococcal toxic shock syndrome(STSS)never seen before in human sufferers.We recently identified the SS2 enolase as an important protective antigen which could protect mice from fatal S.suis 2 infection.In this study,a 2.4-angstrom structure of the SS2 enolase is solved,revealing an octameric arrangement in the crystal.We further demonstrated that the enzyme exists exclusively as an octamer in solution via a sedimentation assay.These results indicate that the octamer is the biological unit of SS2 enolase at least in vitro and most likely in vivo as well.This is,to our knowledge,the first comprehensive characterization of the SS2 enolase octamer both structurally and biophysically,and the second octamer enolase structure in addition to that of Streptococcus pneumoniae.We also investigated the plasminogen binding property of the SS2 enzyme. | Qiong Lu Hao Lu Jianxun Qi Guangwen Lu George F Gao | 2012 | Protein & Cell2012，3，10： | 4 |
| 2 | T-614, a novel immunomodulator, at- tenuates joint inflammation and articular damage in collagen-induced arthritis 显示文摘 | Fang D Liang JL Qiong F | 2008 | Arthritis Resrareh Therapy2008，10，6： | 1 |
| 3 | Dynamic traffic grooming in optical burst-switched networks 显示文摘 | FARID F QIONG Z JASON J | 2005 | Journal of Lightwave Technology2005，23，10： | 1 |
| 4 | Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients显示文摘 | Jian F X Ping H Qiong L L Ting T Z Yi M W Gun A L | 2010 | Clinical Biochem- istry2010，43，： | 1 |
| 5 | Evaluation of environmen-tal impacts of cellulosic ethanol using life cycle assessmentwith echTnological advances over time 显示文摘 | Pawdlzik Paul F Zhang Qiong | 2012 | Biomass &Bioenergy2012，40，： | 1 |
| 6 | The role of barren stalk1 in the architecture of maize显示文摘 | Gallavotti A Qiong Zhao Kyozuka J Meeley R B Ritter M K Doebley J F Schmidt R J | 2004 | Nature2004，432，2： | 1 |
| 7 | Plastic film mulch for half growing-season maximized WUE and yield of potato via moisture-temperature improvement in a semi-arid agroecosystem显示文摘 | Zhao H Xiong Y C Li F M Wang R Y Qiong S C Yao T F | 2012 | Agricultural Water Management2012，104，： | 1 |
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