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| 1 | High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors显示文摘The global COVID-19 coronavirus pandemic has infected over 109 million people,leading to over 2 million deaths up to date and still lacking of effective drugs for patient treatment.Here,we screened about 1.8 million small molecules against the main protease(M^(pro))and papain like protease(PL^(pro)),two major proteases in severe acute respiratory syndrome-coronavirus 2 genome,and identified 1851M^(pro)inhibitors and 205 PL^(pro)inhibitors with low nmol/l activity of the best hits.Among these inhibitors,eight small molecules showed dual inhibition effects on both M^(pro)and PL^(pro),exhibiting potential as better candidates for COVID-19 treatment.The best inhibitors of each protease were tested in antiviral assay,with over 40%of M^(pro)inhibitors and over 20%of PL^(pro)inhibitors showing high potency in viral inhibition with low cytotoxicity.The X-ray crystal structure of SARS-CoV-2 M^(pro)in complex with its potent inhibitor 4a was determined at 1.8Åresolution.Together with docking assays,our results provide a comprehensive resource for future research on anti-SARS-CoV-2 drug development. | Yi Zang Mingbo Su Qingxing Wang Xi Cheng Wenru Zhang Yao Zhao Tong Chen Yingyan Jiang Qiang Shen Juan Du Qiuxiang Tan Peipei Wang Lixin Gao Zhenming Jin Mengmeng Zhang Cong Li Ya Zhu Bo Feng Bixi Tang Han Xie Ming-Wei Wang Mingyue Zheng Xiaoyan Pan Haitao Yang Yechun Xu Beili Wu Leike Zhang Zihe Rao Xiuna Yang Hualiang Jiang Gengfu Xiao Qiang Zhao Jia Li | 2023 | Protein & Cell2023，14，1： | 0 |
| 2 | Countermeasures for Constructing Provincial Modern Agricultural Industrial Park:Taking Jellyfish Industry,the Leading Industry of Yingkou City as an Example显示文摘At present,modern agricultural industrial park with large-scale planting and breeding base as a platform has become an innovative measure to promote the development of regional modern agriculture and an important starting point for the implementation of rural industry revitalization,and it has been highly valued by local governments.Yingkou City has established and developed a modern agricultural industrial park with jellyfish as the leading industry.This will effectively fill the gap in this work in Yingkou City and boost the development of the jellyfish industry.This study provides strong support for the promotion of the city card of'China's Hometown of Jellyfish'. | Qiuxiang HAN Shengzhong DONG Ting LIU Xianghong LIU | 2020 | Asian Agricultural Research2020，12，8： | 0 |
| 3 | Study on the Present Situation and Strategies of Rural Waste Classification Treatment in Northeast China显示文摘The classification treatment of rural domestic waste is not only an important measure to realize the standardized development in rural areas,but also the action support to the concept of'ecological and suitable residence'put forward by the 19th CPC National Congress.This paper summarizes the traditional treatment methods of rural domestic waste in Northeast China,the present situation of rural waste classification treatment in Northeast China and the advantages of waste classification in rural areas of Northeast China.The specific measures to improve the current situation of rural waste classification treatment in Northeast China are put forward in terms of capital policy,classification methods and management means,in order to provide theoretical reference for the treatment of rural domestic waste in Northeast China. | Ting LIU Mengmeng ZHANG Xia PENG Qiuxiang HAN Shengzhong DONG | 2020 | Asian Agricultural Research2020，12，7： | 0 |
| 4 | Current Situation and Development Countermeasures of Local Material Reserves in Liaoning Province显示文摘Local material reserves are an important guarantee for responding to emergencies,maintaining normal economic and social order,and protecting the order of people s life.In order to effectively respond to uncontrollable changes such as natural disasters or epidemic crises,the current situation of local reserves in Liaoning Province was analyzed comprehensively at first,and then the effectiveness,shortcomings and causes of local material reserves were discussed.Finally,some development countermeasures and suggestions were proposed to provide strong support for promoting the high-quality development of local reserve projects. | Shengzhong DONG Qiuxiang HAN Wei DANG | 2021 | Meteorological and Environmental Research2021，12，6： | 0 |
| 5 | Structural insights into signal transduction of the purinergic receptors P2Y_(1)R and P2Y_(12)R显示文摘Dear Editor,The purinergic receptors(P2YRs)are involved in a variety of physiological processes,including proliferation,chemotaxis,cancer metastasis,cardiovascular events,neurodegenerative diseases and aging(Weisman et al.,2012).Thus far,eight human P2YRs have been characterized and are classified into two subfamilies based on their sequence homology and signal transduction mechanisms,including P2Y1 R-like receptors that signal preferentially through Gq/11 proteins and P2Y12R-like receptors that activate Gi/o proteins(Abbracchio et al.,2006). | Beibei Li Shuo Han Mu Wang Yu Yu Limin Ma Xiaojing Chu Qiuxiang Tan Qiang Zhao Beili Wu | 2023 | Protein & Cell2023，14，5： | 0 |
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