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| 1 | Influence of microbial community structure of seed sludge on the properties of aerobic nitrifying granules显示文摘In order to evaluate the influence of microbial community structure of seed sludge on the properties of aerobic nitrifying granules, these granules were cultivated with different seed sludge, and the variation of microbial community and dominant bacterial groups that impact the nitrogen removal efficiency of the aerobic nitrifying granules were analyzed and identified using 16 s rDNA sequence and denaturing gradient gel electrophoresis(DGGE) profiles. The results presented here demonstrated that the influence of the community structure of seed sludge on the properties of aerobic nitrifying granules was remarkable, and the granules cultivated by activated sludge from a beer wastewater treatment plant showed better performance, with a stable sludge volume index(SVI) value of 20 m L/g, high extracellular polymeric substance(EPS) content of 183.3 mg/L, high NH4+-N removal rate of 89.42% and abundant microbial population with 10 dominant bacterial groups. This indicated that activated sludge with abundant communities is suitable for use as seed sludge in culturing aerobic nitrifying granules. | Zhiwei Song Ting Li Qiuxu Wang Yu Pan Lixin Li | 2015 | Journal of Environmental Sciences2015，27，9： | 4 |
| 2 | Comparison of using polyurethane foam passive samplers and tree bark samples from Western China to determine atmospheric organochlorine pesticide显示文摘Polyurethane foam(PUF)passive samplers were deployed and tree bark samples were collected at 15 sites across western China in 2013,and the organochlorine pesticide(OCP)concentrations in the samples were determined.Dichlorodiphenyltrichloroethane and its degradation products(collectively called DDTs),hexachlorocyclohexanes(HCHs),and hexachlorobenzene(HCB)were the dominant OCPs in the PUF samples and tree bark samples.The mean DDTs,HCHs and HCB concentrations were 33,22 and 18 ng/sample in the PUF samples,and 428,74,and 43 ng/(g lipid weight(lw))in the tree bark,respectively.The OCP concentrations in the air,calculated using PUF–air and tree-bark–air partitioning models,were of the same order of magnitude.Both sample types showed that relatively fresh inputs of DDT and HCHs to the environment have occurred in western China.Meanwhile,PUF passive samplers were compared with the use of tree bark samples as passive samplers.The OCP compositions in the PUF and tree bark samples were different.Only the relatively stable OCPs(such as HCB,β-HCH and p,p′-dichlorodiphenyldichloro-ethylene(DDE))were consistent in the PUF and tree bark samples. | Qiuxu Li Yao Lu Jun Jin Guangyao Li Peng Li Chang He Ying Wang | 2016 | Journal of Environmental Sciences2016，28，3： | 2 |
| 3 | Moisture Absorption and Mechanical Properties of Chemically Modified Linen/Polypropylene Composites显示文摘 | HU Qiuxue LI Li YAN Wenling ZHAO Qi ZHANG Niaona ZHANG Yumei DONG Jinbiao LIU Baijun HU Wei | 2017 | Chemical Research in Chinese Universities2017，33，6： | 1 |
| 4 | A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors显示文摘Poly(ADP-ribose)polymerase(PARP)inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination(HR)deficiency.However,many patients without apparent HR defects also respond well to PARP inhibitors/cisplatin.The biomarker responsible for this mechanism remains unclear.Here,we identified a set of ribosomal genes that predict response to PARP inhibitors/cisplatin in HR-proficient patients.PARP inhibitor/cisplatin selectively eliminates cells with high expression of the eight genes in the identified panel via DNA damage(ATM)signaling-induced pro-apoptotic ribosomal stress,which along with ATM signaling-induced pro-survival HR repair constitutes a new model to balance the cell fate in response to DNA damage.Therefore,the combined examination of the gene panel along with HR status would allow for more precise predictions of clinical response to PARP inhibitor/cisplatin.The gene panel as an independent biomarker was validated by multiple published clinical datasets,as well as by an ovarian cancer organoids library we established.More importantly,its predictive value was further verified in a cohort of PARP inhibitor-treated ovarian cancer patients with both RNA-seq and WGS data.Furthermore,we identified several marketed drugs capable of upregulating the expression of the genes in the panel without causing HR deficiency in PARP inhibitor/cisplatin-resistant cell lines.These drugs enhance PARP inhibitor/cisplatin sensitivity in both intrinsically resistant organoids and cell lines with acquired resistance.Together,our study identifies a marker gene panel for HR-proficient patients and reveals a broader application of PARP inhibitor/cisplatin in cancer therapy. | Chao Zhang Qiang Guo Lifeng Chen Zheming Wu Xiao-Jian Yan Chengyang Zou Qiuxue Zhang Jiahong Tan Tian Fang Qunxian Rao Yang Li Shizhen Shen Min Deng Liewei Wang Huanyao Gao Jia Yu Hu Li Cheng Zhang Somaira Nowsheen Jake Kloeber Fei Zhao Ping Yin Chunbo Teng Zhongqiu Lin Kun Song Shuzhong Yao Liangqing Yao Lingying Wu Yong Zhang Xiaodong Cheng Qinglei Gao Jian Yuan Zhenkun Lou Jin-San Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
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