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| 1 | Wang-Bi tablet, a patented Chinese medicine, maintains the balance of Th1/Th2 in mice with collagen-induced arthritis显示文摘OBJECTIVE: To investigate the pharmacological mechanism of Wang-Bi tablets(WBTs), a Chinese patented medicine, in rheumatoid arthritis(RA) using mice with collagen-induced arthritis(CIA).METHODS: A mouse model of CIA was induced using bovine type Ⅱ collagen. WBT treatment was administered and efficacy was evaluated. The levels of interferon-γ(IFN-γ), interleukin-2(IL-2), and interleukin-4(IL-4) were examined using an enzyme-linked immunosorbent assay, and the proportions of Th1 and Th2 were detected using flow cytometry. T-bet and GATA-binding protein 3(GATA3)expression were demonstrated using Western blot analysis.RESULTS: Paw swelling and the arthritis index decreased significantly following WBT treatment. Histopathological analysis revealed markedly alleviated damage to synovium tissue in the WBT and methotrexate treatment groups. WBT regulated the production of IFN-γ, IL-2, and IL-4 and modulated Th1 and Th2 cell populations, which might have been induced by the attenuation of Th1 and Th2 cell differentiation through a decrease in the expression of T-bet and an increase in the expression of GATA3 in the synovial tissue in CIA mice.CONCLUSION: These results indicate that WBT may produce a therapeutic effect on CIA through maintaining the balance of Th1/Th2 cells, which could result in a decrease in the autoinflammatory disorder observed in RA. | Wang Jianming Luo Jing Xu Yuan Yan Zeran Qu Xiangke Chen Mengxue Tao Qingwen | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
| 2 | A Profile of Native Integration Sites Used by φC31 Integrase in the Bovine Genome显示文摘Streptomyces 噬菌体 C31 integrase 能高效地在哺乳动物的染色体以内指向忍受 attB transgenes 到内长的假 attP 地点。更好在牛的染色体理解 C31 integrase 的活动, 44 个集成事件的 DNA 序列被分析,并且 32 个假 attP 地点被识别。这些地点的多数分享包含转换重复并且有类似到野类型的 attP 的一个顺序主题地点。Genomic DNA flanking 这些地点典型地包含了重复顺序元素,例如短、长的散布重复元素。这些顺序特征显示 DNA 顺序识别在指导调停 C31 的地点特定的集成起一个重要作用。另外, BF27 集成热点地点在牛的染色体被识别,它说明了 13.6% 所有孤立的集成事件并且印射到 intron 在肝癌症 1 删除了(DLC1 ) 基因。另外,我们发现在牛的染色体的假 attP 地点在人的染色体和那些一样有另外的特征。这研究代表在牛的染色体的假 attP 地点的顺序特征被分析的第一次。我们断定这个地点特定的 integrase 系统为牛的染色体的应用修正有大潜力。 | Lijuan Qu Qingwen Ma Zaiwei Zhou Haiyan Ma Ying Huang Shuzhen Huang Fanyi Zeng Yitao Zeng | 2012 | Journal of Genetics and Genomics2012，39，5： | 1 |
| 3 | Velocity analysis for layered viscosity model under thin film lubrication显示文摘 | Qu Qingwen Wang Mei Chai Shan | 2001 | Tribology International2001，，34： | 1 |
| 4 | A Continuous Viscosity Model for Thin Film Lubrication显示文摘 | Qu Qingwen Wang Mei Wang Lihua | 2002 | Tribology International2002，35，7： | 1 |
| 5 | An Adsorbent Layer Model for Thin Film Lubrication 显示文摘 | Qu Qingwen Hu Yahong Zhu Jun | 1998 | Wear1998，221，： | 1 |
| 6 | Velocity Analysis for Layered Viscosity Model under Thin Film Lubrication 显示文摘 | Qu Qingwen Wang Mei Chai Shan Yao Fusheng | 2001 | Tribology International2001，34，： | 1 |
| 7 | An adsorbent layer model for thin film lubrication 显示文摘 | Qu Qingwen Hu Yahong Zhu Jun | 1998 | Wear1998，，221： | 1 |
| 8 | An adsorbent layer model for thin film lubrication 显示文摘 | Qu Qingwen Hu Yahong Zhu Jun | 1998 | Wear1998，221，： | 1 |
| 9 | Velocity analysis for layered viscosity model under thin film lubrication显示文摘 | Qingwen Qu Mei Wang Shan Chai | 2001 | Tribology International2001，34，8： | 1 |
| 10 | Finite element method for one-dimensional rill erosion simulation on a curved slope显示文摘Rill erosion models are important to hillslope soil erosion prediction and to land use planning.The development of rill erosion models and their use has become increasingly of great concern.The purpose of this research was to develop mathematic models with computer simulation procedures to simulate and predict rill erosion.The finite element method is known as an efficient tool in many other applications than in rill soil erosion.In this study,the hydrodynamic and sediment continuity model equations for a rill erosion system were solved by the Galerkin finite element method and Visual Cþþprocedures.The simulated results are compared with the data for spatially and temporally measured processes for rill erosion under different conditions.The results indicate that the one-dimensional linear finite element method produced excellent predictions of rill erosion processes.Therefore,this study supplies a tool for further development of a dynamic soil erosion prediction model. | Lijuan Yan Tingwu Lei Jing Zhang Qingwen Zhang Liqin Qu | 2015 | International Soil and Water Conservation Research2015，3，1： | 0 |
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