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| 1 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 2 | Palmar lunate trans-scaphoid,trans-trique- tral fracture-dislocation 显示文摘 | Harrington P Quinlan WB | 1999 | J Hand Surg [ Br ]1999，24，4： | 1 |
| 3 | Randomised controlled trial of a synthetic triglyceride milk formula for preterm infants显示文摘 | Lucas A Quinlan P Abrams S | 1997 | Archives of Disease in Childhood1997，77，3： | 1 |
| 4 | Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy显示文摘 | Thompson AM Johnson A Quinlan P | 2011 | Breast Cancer Res Treat2011，125，1： | 1 |
| 5 | p53 mutation, deprivation and poor prognosis in primary breast cancer显示文摘 | BAKER L QUINLAN P R PATTEN N | 2010 | Br J Cancer2010，102，： | 1 |
| 6 | Randomized controlled trial of a synthetic triglyceride milk formula for preterm infants 显示文摘 | Lucas A Quinlan P Abrams S | 1997 | Arch Dis Child Fetal Neonatal Ed1997，77，3： | 1 |
| 7 | Effect of paclobutrazol(PP333) on apple shoot growth显示文摘 | QUINLAN J D RICHARDSON P J | 1984 | Acta Hortic1984，146，： | 1 |
| 8 | Randomised controlled trial of a synthetic triglyceride milk formula for preterm infants显示文摘 | Lucas A Quinlan P Abrams S | 1997 | Arch Dis Child Fetal Neonatal Ed1997，77，3： | 1 |
| 9 | Iron-based redox processes 显示文摘 | Michael P Quinlan | 1992 | Sulphur1992，，222： | 1 |
| 10 | Distribution of trans-vaccenic acid and cis9, trans11-conjugated linoleic acid (rumenic acid) in blood plasma lipid fractions and secretion in milk fat of Jersey cows fed canola or soybean oil 显示文摘 | Loot J J Quinlan L E Bandara A B P A | 2002 | Anim Res2002，51，2： | 1 |
| 11 | Chemical induction of branching in nursery trees显示文摘 | QUINLAN J D PRESTON A P | 1973 | Acta Horticulturae1973，34，： | 1 |
| 12 | Synthesis and crystal structure of maricite and sodium iron(III) hydroxyphosphate显示文摘 | Bridson J N Quinlan S E Tremaine P R | 1998 | Chemistry of Materials1998，10，3： | 1 |
| 13 | Renal hypoplasia: Lessons from Pax2 显示文摘 | Dziarmaga A Quinlan J Goodyer P | 2006 | Pediatr Nephrol2006，21，1： | 1 |
| 14 | ECT treatment of malignant catatonia/NMS in an adolescent:a useful lesson in delayed diagnosis and treatment显示文摘 | Ghaziuddin N Alkhouri I Champine D Quinlan P Fluent T Ghaziuddin M | | 0，，02： | 1 |
| 15 | Study of Reaction Be- tween a Low Molecular Weight, Highly Functionalized Polyethy lene and Hexamethylenediamine显示文摘 | Hameed T Quinlan P J Potterl D K | 2012 | Maeromol Mater Eng2012，297，1： | 1 |
| 16 | Solvent exposures and parkinson disease risk in twins显示文摘 | Goldman SM Quinlan P J Ross GW | 2012 | Ann Neurol2012，71，： | 1 |
| 17 | Progesterone receptor expression is an independent prognostic variable in early breast cancer: a population-based study 显示文摘 | Purdie CA Quinlan P Jordan LB | 2014 | Br J Cancer2014，110，3： | 1 |
| 18 | Renal hypoplasia: lessons from Pax2 显示文摘 | Dziarmaga A Quinlan J Goodyer P | 2006 | Pediatr Nephrol2006，21，1： | 1 |
| 19 | Inhi- bition of amyloid 显示文摘 | CABALEIRO L C QUINLAN P F LYNCH I | 2008 | J Am Chem Soc2008，130，15： | 1 |
| 20 | Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases small star,filled显示文摘 | Girao H Pereira P Ramalho J Quinlan R Preseott A | 2003 | Exp Cell Res2003，291，2： | 1 |
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