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| 1 | Pacemaker therapy in very elderly patients: survival and prognostic parameters of single center experience显示文摘Background Permanent pacing is the therapy of choice for treating severe and/or symptomatic bradyarrhythmias. The number of very elderly patients receiving pacemakers is increasing and little is known about survival in this specific subgroup. This study is aimed at assessing the actual survival of patients requiring pacing therapy at age > 85 years and investigating variables associated with death. Methods Between 2010 and 2017, 572 patients aged ≥ 85 years underwent pacemaker implantation for conventional bradycardia indications in Department of Cardiology, S. Chiara Hospital, Italy. Results Thirty percent of patients were ≥ 90-year-old and comorbidities were frequent. Fifty-seven percent of patients required pacing for prognostic reasons(acquired atrioventricular block), and the remaining for relief of bradycardia symptoms. A dual-chamber pacemaker was implanted in 34% of patients. The 5-year survival was 45%(standard error: 3%), and the 8-year survival was 26%(standard error: 4%). The risk of death was similar in patients who received pacemaker for symptom relief and for prognostic reasons in the overall population(HR = 1.19, 95% CI: 0.93–1.52, P = 0.156), as well as in the ≥ 90-year-old group(HR = 1.39, 95% CI: 0.92–2.11, P = 0.102). At multivariate analysis, following variables were associated with death: higher age, lower ejection fraction, dementia/dysautonomia and diagnosis of cancer. The pacing indication and the implantation of a single chamber pacemaker were not associated with worse prognosis. Conclusions This study showed a good life expectancy in patients aged ≥ 85 years who received a pacemaker. Strong risk factors for all-cause death were non-cardiac. Pacemaker therapy seems a clinically effective therapeutic option to improve survival and to control bradyarrhythmia-related symptoms in very elderly patients. | Massimiliano Marini Marta Martin Michela Saltori Silvia Quintarelli Filippo Zilio Fabrizio Guarracini Alessio Coser Sergio Valsecchi Roberto Bonmassari | 2019 | Journal of Geriatric Cardiology2019，16，12： | 3 |
| 2 | Engineering CD19-specific T lymphocytes with interieukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety显示文摘 | Hoyos V Savoldo B Quintarelli C | 2010 | Leukemia2010，24，6： | 1 |
| 3 | Model-Checking Based Data Reatrieval显示文摘 | Agostino Dovier Elisa Quintarelli | 2004 | SpringerVerlag2004，，： | 1 |
| 4 | Identification of Annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells显示文摘 | Irene Colavita Nicola Esposito Concetta Quintarelli Ersilia Nigro Fabrizio Pane Margherita Ruoppolo Francesco Salvatore | 2013 | Proteomics2013，，16： | 1 |
| 5 | Engineering CD19- ~pecific T lymphoeytes with interleukin-15 and a suicide gene to mhance their anti-lymphoma/leukemia effects and safety 显示文摘 | Hoyos V Savoldo B Quintarelli C | 2010 | ~eukemia2010，24，6： | 1 |
| 6 | Co-expression of cytokine and suicide genes to enhance the activity and safety of tumorspecific cytotoxic T lymphocytes显示文摘 | Quintarelli C Vera JF Savoldo B | | 0，，08： | 1 |
| 7 | Data Mining forXML Query-answering Support 显示文摘 | Mazuran M Quintarelli E Tanca L | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，8： | 1 |
| 8 | Gene therapy to improve function of T cells for a- doptive immunotherapy 显示文摘 | Quintarelli C Savoldo B Dotti G | 2010 | Methods Mol Biol2010，651，： | 1 |
| 9 | Age-dependent changes on the state of aggregation of cartilage matrix显示文摘 | Quintarelli G Ippolito E Roden L | | Lab InvesLl9750，32，1： | 1 |
| 10 | Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosup- pressive drug taerolimus (FK506)显示文摘 | Angelis BD Dotti G Quintarelli C | 2009 | Blood2009，114，： | 1 |
| 11 | Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes显示文摘 | Quintarelli C Vera J F Savoldo B | | 0，，08： | 1 |
| 12 | Coexistence of anti - phos- pholipid antibodies and endothelial perturbation in systemic lupus erythematosas patients with ongoing prothrombotic state显示文摘 | Ferro D Pittoni V Quintarelli C | 1997 | Circulation1997，95，6： | 1 |
| 13 | Hepatitis B virus reactivation after fludarabine-based regimens for indolent non-Hodgkin's lymphomas:high prevalence of acquired viral genomic mutations显示文摘 | Picardi M Pane F Quintarelli C | | Haematologica0，，： | 1 |
| 14 | Engineering CDl9-specific T lymphocytes with interleukin-15 and a suicide gene toenhance their anti-lymphoma/leukemia effects and safety显示文摘 | Hoyos V Savoldo B Quintarelli C | 2010 | Leukemia2010，24，6： | 1 |
| 15 | Age changes in the localization and distribution of glycosaminoglycans in human hyaline cartilage显示文摘 | Quintarelli G Dellovo D | 1966 | Histochemie1966，7，1： | 1 |
| 16 | Integrating Bottom-up and Top-down Classification in a Social Tagging System显示文摘 | Quintarelli E Resmini A Rosati L | 2007 | Bulle- tin of the American Society for Information Science and Technology2007，33，5： | 1 |
| 17 | Engineering CD19-spe- cific T lymphocytes with interleukin-15 and a suicide gene to en- hance their anti-lymphoma/leukemia effects and safety 显示文摘 | Hoyos V Savoldo B Quintarelli C | 2010 | Leu- kemia2010，24，6： | 1 |
| 18 | Coexistence of antiphospholipid antibodies and endothelial perturbation in systemic lupus erythematosus patients with on - going prothrombotic state 显示文摘 | Ferro D Pittoni V Quintarelli C | 1997 | Thromb Haemost1997，，： | 1 |
| 19 | Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes显示文摘 | Quintarelli C Vera JF Savoldo B | 2007 | Blood2007，110，8： | 1 |
| 20 | BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations 显示文摘 | Pane F Intriefi M Quintarelli C | 2002 | Oncogene2002，21，： | 1 |
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