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| 1 | Stem cell-based therapy for human diseases显示文摘Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment. | Duc M.Hoang Phuong T.Pham Trung Q.Bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh Nguyen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 7 |
| 2 | MicroRNA-22 inhibits proliferation and promotes differentiation of satellite cells in porcine skeletal muscle显示文摘Pig is an important economic animal in China. Improving meat quality and meat productivity is a long time issue in animal genetic breeding. Micro RNAs(mi RNAs) are short non-coding RNAs that participate in various biological processes, such as muscle development and embryogenesis. mi R-22 differentially expresses in embryonic and adult skeletal muscle. However, the underlying mechanism is unclear. In this study, we investigated mi R-22 function in proliferation and differentiation of porcine satellite cells(PSCs) in skeletal muscle. Our data show that mi R-22 expressed in both proliferation and differentiated PSCs and is significantly upregulated(P<0.05) during differentiation. After treated with the mi R-22 inhibitor, PSCs proliferation was significantly increased(P<0.05), as indicated by the up-regulation(P<0.01) of cyclin D1(CCND1), cyclin B1(CCNB1) and down-regulation(P<0.05) of P21. Conversely, over-expression of mi R-22 resulted in opposite results. Differentiation of PSCs was significantly suppressed(P<0.05), evidenced by two major myogenic markers: myogenin(Myo G) and myosin heavy chain(My HC), after transfecting the PSCs with mi R-22 inhibitor. Opposite results were demonstrated in the other way around by transfection with mi R-22 mimics. In conclusion, the data from this study indicated that mi R-22 inhibited the PSCs proliferation but promoted their differentiation. | Hong Quyen Dang XU Gu-li HOU Lian-jie XU Jian HONG Guang-liang Chingyuan Hu WANG Chong | 2020 | Journal of Integrative Agriculture2020，19，1： | 5 |
| 3 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 4 | Sensing and lasing applications of whispering gallery mode microresonators显示文摘 | Yu Zheng Zhifang Wu Perry Ping Shum Zhilin Xu Gerd Keiser Georges Humbert Hailiang Zhang Shuwen Zeng Xuan Quyen Dinh | 2018 | Opto-Electronic Advances2018，1，9： | 3 |
| 5 | Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting显示文摘 | Quyen Dao Padma Krishnaswamy Radmila Kazanegra Alex Harrison Rambod Amirnovin Leslie Lenert Paul Clopton Joel Alberto Patricia Hlavin Alan S Maisel | 2001 | Journal of the American College of Cardiology2001，，2： | 2 |
| 6 | Specific or ad valorem tax for an exhaustible resource?显示文摘 | Hung N M Quyen N V | 2009 | Economics Letters2009，102，2： | 1 |
| 7 | Anticipation of epileptic seizures from standard EEG recordings显示文摘 | Le Van Quyen M Martinerie J | 2001 | The Lancet2001，，357： | 1 |
| 8 | High-level expression of a lipase from Bacillus thermocatenulatus BTL2 in Pichia pastoris and some properties of the recombinant lipase显示文摘 | SCHMIDT D C | 2003 | Protein Expression & Purification2003，28，1： | 1 |
| 9 | Seizure an- ticipation in human neocortical partial epilepsy显示文摘 | Navarro V Martinerie J Le Van Quyen M | 2002 | Brain2002，，125： | 1 |
| 10 | Analysis of the complete genome sequence and capsid region of black queen cell viruses from infected honeybees (Apis me llifera) in Korea显示文摘 | REDDY KE NOH JH CHOE SE KWEON CH YOO MS DOAN HT RAMYA M YOON BS NGUYEN LT NGUYEN TT VAN QUYEN D JUNG SC CHANG KY KANG SW | 2013 | Virus Genes2013，47，1： | 1 |
| 11 | Optical immunoassay for snake venom detection显示文摘 | Dong le V Eng K H Quyen le K | 2004 | Biosens Bioelectron2004，19，10： | 1 |
| 12 | Classification of Underwater Mammals Using Feature Extraction Based on Time-Frequency Analysis and BCM Theory 显示文摘 | QUYEN Q H LEON N C NATHAN I | 1998 | IEEE Transactions on Signal Processing1998，46，5： | 1 |
| 13 | The clinical benefit of adjunctive dexamethasone in tuberculous meningitis is not associated with measurable attenuation of peripheral or local immune responses显示文摘 | Simmons CP Thwaites GE Quyen NTH | 2005 | Journal of Immunology2005，175，1： | 1 |
| 14 | High-level expression of a lipase from Bacillus thermocatenulatus BTL2 in Pichia pastoris and some properies of the recombinantlipase显示文摘 | QUYEN D T SCHMIDT D C | 2003 | Protein Expression&Purification2003，28，1： | 1 |
| 15 | Anticipating epileptic seizures in real time by a non-linear analysis of similarity between EEG recordings显示文摘 | Le Van Quyen M Martinerie J Baulac M Varela F | 1999 | Neuro Report1999，，10： | 1 |
| 16 | Characterizing neurodynamic changes before seizures显示文摘 | LE VAN QUYEN M MARTINERIE J NAVARRO V | 2001 | Clin Neurophysiol2001，18，3： | 1 |
| 17 | Spatiotemporal characterizations of nonlinear changes in intracranial activities prior to human temporal lobe seizures 显示文摘 | le van Quyen M Adam C Martinerie J | 2000 | Eur J Neurosci2000，12，6： | 1 |
| 18 | Seizure anticipa- tion in human neocortical partial epilepsy 显示文摘 | Navarro V Martinerie J Le Van Quyen M | 2002 | Brain2002，125，3： | 1 |
| 19 | Specific or ad valorem tax for an exhaustible resource?显示文摘 | N.M. Hung N.V. Quyen | 2009 | Economics Letters2009，，2： | 1 |
| 20 | Epileptic seizures can be antieipaled by nonlinear analysis显示文摘 | Martinerie J Adam C le van Quyen M | 1998 | Nat Med1998，4，10： | 1 |
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