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| 1 | 转基因大麦中gfp基因的染色体位置及其表达(英文)显示文摘通过对大麦小孢子进行基因枪轰击获得 4株转绿色荧光蛋白基因 (gfp)的植株 (A、C、D、E) ,以gfp基因为探针进行荧光原位杂交 (FISH)研究转化植株中转基因插入位置和基因表达。 4个株系在染色体 7L(5HL)的不同位置都有一个插入点 ,而E株系在染色体 5S(7HS)还有第 2个插入点。所有的转基因T0 代植株都是半合子并在T1、T2代发生分离。D株系GFP未表达 ,但FISH和PCR分析表明gfp基因已成功插入其染色体。各株系在根尖和花粉中的GFP表达水平不同 :C株系在花粉表达强而在根尖表达中等 ;A株系在花粉中等表达而在根尖表达较淡 ;E株系则在根尖高表达 ,花粉中等表达。A和C株系在根尖和花粉的GFP分离都表现单位点特性 ,而E株系的根尖分离表现重叠作用 (15∶1)特征 ,但在花粉中表达GFP的频率低。PCR结果和 3个分离株系的根尖表达结果一致。D和E株系的GFP表达不正常可能和gfp基因插入位置或基因的结构有关。 | 陈建民 Carlson A R 万建民 Kasha K J | 2003 | Acta Genetica Sinica2003，30，8： | 6 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Effect of river landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes(ARG)显示文摘 | PEI R KIM S C CARLSON K H PRUDEN A | 2006 | Water Res2006，40，12： | 1 |
| 4 | RH-5849, a nonsteroidal ecdysone agonist: effects on larval lepidoptera 显示文摘 | K D Wing R A Slawecki G R Carlson | 1988 | Science1988，241，： | 1 |
| 5 | Variability of apatite fission track annealing kinetics III: extrapolation to geological time scales 显示文摘 | Ketcham R A Donelick R A Carlson W D | 1999 | American Mineralogist1999，84，9： | 1 |
| 6 | Development of new feeding-distance rules using casting simulation: part II, the new rules 显示文摘 | Ou S Carlson K D Hardin R A | 2002 | Metallurgical and Materials Transactions B2002，33，： | 1 |
| 7 | Alter-ation in the hypothalamic-pituitary-ovarian axis in depressed women显示文摘 | YOUNG E A MIDGLEY A R CARLSON N E | 2000 | Arch Gen Psychiatry2000，57，12： | 1 |
| 8 | Cropping sequence and tillage system influences annual crop production and water use in semiarid Montana,USA显示文摘 | Lenssen A W Johnson G D Carlson G R | 2007 | Field Crops Res2007，100，1： | 1 |
| 9 | Extraction of lemongrass essential oil with dense carbon dioxide显示文摘 | Carlson L H C Machado R A F Spricigo C B | 2001 | J Supercrit Fluids2001，21，： | 1 |
| 10 | Identification of volatile metabolltes from five fungal species cuItivatecl on two meclia显示文摘 | Sunesson A L Vaes W H J Nilsson C A Blomquist G Andersson B Carlson R | 1995 | Appl Environ Microbiol1995，61，： | 1 |
| 11 | The parameter R2 in multiquadric interpolation显示文摘 | Carlson R E Foley T A | 2001 | Computers and Mathematics with Application2001，21，9： | 1 |
| 12 | Response of antibiotic resistance genes (ARG) to biological treatment in dairy lagoon water显示文摘 | Pei R Cha J Carlson K H Pruden A | 2007 | Environ Sci Technol2007，41，： | 1 |
| 13 | Osteo-chondro- progenitor-specific deletion of the selenocysteine tRNA gene, Trsp,leads to ehondronecrosis and abnormal skeletal develop- ment: A putative model for Kashin-Beck disease 显示文摘 | Downey C M Horton C R Carlson B A | 2009 | PLoS Genet2009，5，10： | 1 |
| 14 | Ubiquitous tar balls with a California-source signature on the shorelines of Prince William Sound, Alaska显示文摘 | Kvenvolden K A Hostettler F D Carlson P R Rapp J B Threlkeld C N Warden A | 1995 | Environ Sci Technol1995，29，10： | 1 |
| 15 | Variability of Apatite Fission-track Annealing Kinetics Ⅲ: Extrapolation to Geological Time Scales 显示文摘 | Ketcham R A Donelick R A Carlson W D | 1999 | American Mineralogist1999，9，： | 1 |
| 16 | Commercial Application of Continuous Oxygen in Iron Cupolas显示文摘 | Carlson R Hamilton J A and Koepplin W J | 1966 | AFS Transactions1966，74，： | 1 |
| 17 | Variability of apatite fission-track annealing kinetics Ⅲ: Extrapolation to geological time scales显示文摘 | Donelick R A Carlson W D | 1999 | American Mineralogist1999，9，： | 1 |
| 18 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 19 | An au- tomated, handheld biosensor for aflatoxin显示文摘 | Carlson M A Bargeron C B Benson R C | 2000 | Biosens Bioeleetron2000，14，1011： | 1 |
| 20 | Variability of apatite fission track annealing kinetics 11: crystallographic orientation effects显示文摘 | Donelick R A Ketcham R A Carlson W D | 1999 | American Mineraloeist1999，84，： | 1 |
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