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| 1 | Abnormal activation of the synuclein-gamma gene in hepatocellular carcinomas by epigenetic alteration.显示文摘 | Zhao W Liu H Liu W Wu Y Chen W Jiang B Zhou Y Xue R Luo C Wang L Jiang JD Liu J | 2006 | 中国生物学文摘2006，20，4： | 31 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest China显示文摘Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong site.AMS radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 ka.Archaeomagnetic analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d interstadial.Human remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 ka.Anthropogenic features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic analysis.Two monkey fossils are described here,one of them being reassigned from Macaca robustus to M.aff.M.assamensis.They confirm the young age of the site and also show signs of anthropogenic alteration in the form of burning.Additional human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic humans.The presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene. | JI XuePing CURNOE Darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TACON Paul S C | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 4 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 5 | A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication显示文摘 | Xiang R Mizutani N Luo Y Chiodoni C Zhou H Mizutani M | 2005 | Cancer Res2005，65，： | 1 |
| 6 | Improved morphology for ohmic contacts to AlGaN/GaN high electron mobility transistors using WSix or W-based metallization显示文摘 | LUO B REN F FITCH R C | 2003 | Appl Phys Lett2003，82，22： | 1 |
| 7 | Pattern Vectors from Algebraic Graph Theory显示文摘 | Wilson R C Hancock E R Luo B | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，： | 1 |
| 8 | Design and Implementation of Capacitive Proximity Sensor Using Microelectromechanical Systems Technology显示文摘 | Chert Z H Luo R C | 1998 | IEEE Transactions on Industrial E1 EC2 Tronics1998，45，6： | 1 |
| 9 | Cytotoxic coumaronochromones from the roots of Euchresta formosana 显示文摘 | Luo W L Chang R Liaw C C | 2002 | Planta Med2002，68，2： | 1 |
| 10 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 11 | Phototactic behavior of armand pine bark-weevil, Pissodes punctatus ( Coleoptera : Curculionidae) 显示文摘 | Cheu Y Luo C W Kuang R P | 2013 | Journal of Insect Science2013，3，： | 1 |
| 12 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 13 | A study of colour emotion and colour preference (Part I) :Colour emotions for single eolours 显示文摘 | Ou L C Luo M R Woodcock A | 2004 | Color Research and Application2004，29，3： | 1 |
| 14 | Chemical composition of the continental crust in the Qinling Orogenic Belt and its adjacent North China and Yangtze cratons显示文摘 | ZHANG B R LUO T C | 1992 | Geochim Cosmochim Acta1992，56，： | 1 |
| 15 | Fractal-based classification of natural textures显示文摘 | Potlapalli H Luo R C | 1998 | IEEE transanctions on Industrial Electronics1998，45，1： | 1 |
| 16 | Muhisens,r Integration and Fusion Issues and Approaches显示文摘 | Luo R C et aI | 1988 | Proc SPIE1988，9，： | 1 |
| 17 | Uniform Colour Spaces Based on CIECAM02 Colour Appearance Model 显示文摘 | LUO M R CUI G LI C | 2006 | Color Research and Application2006，31，4： | 1 |
| 18 | A study of colour emotion and colour preference (Part III) :Colour preference modeling 显示文摘 | Ou L C Luo M R Woodcock A | 2004 | Color Research and Application2004，29，5： | 1 |
| 19 | Effect of dietary copper and fat on nutrient ultilization,digestive enzyme activites, and tissue mineral levels in weanling pigs显示文摘 | Luo X G Dove C R | 1996 | J Anim Sci1996，74，： | 1 |
| 20 | Characterization and solution properties of a novel watersoluble terpolymer for enhanced oil recovery 显示文摘 | ZHONG C R LUO P Y YE Z B | 2009 | Polymer Bulletin2009，62，1： | 1 |
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