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| 1 | MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘 | Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R | 2009 | 中国神经肿瘤杂志2009，7，4： | 56 |
| 2 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 3 | Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner显示文摘Cold-inducible RNA-binding protein (CIRP) is a novel inflammatory mediator that stimulates the release of proinflammatory cytokines from macrophages in sepsis. Given the immune dysregulation that characterizes sepsis, the effect of CIRP on other immune cells is an area of increasing interest that has not yet been studied. In the present study, we hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. We observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 h on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. Furthermore, at 20 h after receiving intravenous injection of recombinant murine CIRP (rmCIRP, 5 mg/kg body weight (BW)) or PBS (vehicle), those mice receiving rmCIRP showed significantly increased expression of CD69 and CD25 on both CD4+ and CD8+ splenic T cells. This effect, however, was not seen in TLR4-deficient mice after rmCIRP injection. In addition, treatment with CIRP predisposed CD4+ T cells to a Th1 hyperinflammatory response profile, and influenced CD8+ T cells toward a cytotoxic profile. Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner. | Alexandra C Bolognese Archna Sharma Weng-Lang Yang Jeffrey Nicastro Gene F Coppa Ping Wang | 2018 | Cellular & Molecular Immunology2018，15，1： | 4 |
| 4 | Rescue of influenza B virus from eight plasmids显示文摘 | Hoffmann E Mahmood K Yang C F | 2002 | Proc Natl Acad Sci USA2002，99，11： | 2 |
| 5 | Phylogenetic relationships of the Tropiduchidae-group(Homoptera:Fulgoroidea)of planthoppers inferred through nucleotide sequences显示文摘 | YEH W B YANG C T HUI C F | 1998 | Zool Stu1998，37，1： | 2 |
| 6 | Microwave dielectric characteristics of (Bi1-cxSmx)NbO4显示文摘 | Tzou W C Yang C F | 2002 | Ceram Int2002，28，： | 1 |
| 7 | Physical properties of R-PET/ CD-PET poly blended hollow filaments their kinetics of alkaline hydrolysis显示文摘 | Hsiao K J Jen Z F Yang J C | 2002 | J Polym Res2002，9，12： | 1 |
| 8 | Quantification of rib COL1A2 gene expression in healthy and fluorosed Inner Mongolia cashmere goats显示文摘 | Li W T Yang L F Ren Y C | 2007 | Fluoride2007，40，1： | 1 |
| 9 | Wave-induced mixing in the Yellow Sea 显示文摘 | YANG Y Z QIAO F L XIA C S | 2004 | Chin J Oceano Limnol2004，22，3： | 1 |
| 10 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 11 | 5-link model based gait trajectory adaption control strategies of the gait rehabilitation exoskeleton for post-stroke patients显示文摘 | Zhang J F Dong Y M Yang C J | 2010 | Mechatronics2010，20，3： | 1 |
| 12 | Expression and localization of human lysozyme in the endosoerm of transgenic rice 显示文摘 | YANG D C GUO F L Liu B | 2003 | Planta2003，216，： | 1 |
| 13 | Intratypic recombination among lineages of type 1 vaccine - derived poliovirus emerging during chronic infection of an immunodeficient patient显示文摘 | Yang C F Chen H Y Jorba J | 2005 | J Virol2005，79，12： | 1 |
| 14 | Analysis of marker or complex chromosomal rearrangements present in pre-and post-natal karyotypes utilizing a combination of G-banding,spectral karyotyping and fluorescence in situ hybridization 显示文摘 | Heng H H Ye C J Yang F | 2003 | Clin Genet2003，63，5： | 1 |
| 15 | Color image segmentation using fuzzy C-mean and eigenspace projections显示文摘 | YANG J F HAO S S CHUNG P C | 2002 | Signal Prooeming2002，82，3： | 1 |
| 16 | Study on microhardness of bulk nanocrystalline copper 显示文摘 | YANG M C YE F SUN X K | 1997 | Nanostruetured Materials1997，9，48： | 1 |
| 17 | Effects of prolactin-releasing peptide on tuberoinfundibular dopaminergic neuronal activity andprolactin secretion in estrogen-treated female rats显示文摘 | Yuan Z F Yang S C Pan J T | 2002 | J Biomed Sci2002，9，： | 1 |
| 18 | Photocatalytic activity of WOX- TiO2 under visible light irradiation显示文摘 | Li X Z Li F B Yang C L | 2001 | J Photochem Photobiol A : Chem2001，141，23： | 1 |
| 19 | Analysis of Unsteady Inviscid Diffuser Flow with a Shock Wave 显示文摘 | Yang V Culick F E C | 1985 | Journal of Propulsion and Power1985，1，3： | 1 |
| 20 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
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