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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Storm pattern effect on nitrogen and phosphorus losses in surface runoff显示文摘 | Flanagan D C Foster G R | 1989 | Transactions of the ASA- BE1989，32，2： | 1 |
| 3 | Development of a sutureless dural substitute from Bombyx mori silk fibroin显示文摘 | Flanagan KE Tien LW Elia R | 2015 | J Biomed Mater Res B Appl Biomater2015，103，3： | 1 |
| 4 | Multiple logistic regression analysis of plasma paraquat concentrations as a predictor of outcome in 375 cases of paraquat poisoning 显示文摘 | Jones AL Elton R Flanagan R | 1999 | Q J Med1999，92，10： | 1 |
| 5 | Re- sponses of boreal conifers to climate fluctuations: indications from tree-ring widths and carbon isotope analyses显示文摘 | BROOKS J R FLANAGAN L B EHLERINGER J R | 1998 | Can J For Res1998，28，： | 1 |
| 6 | Proof of classical version of the bousso entropy of the generalized second low显示文摘 | Flanagan E E Marolf D Wald R M | 2000 | Phys Rev2000，，62： | 1 |
| 7 | Analytical toxicology:guidelines for sample collection postmortem显示文摘 | Flanagan R J Connally G Evans J M | 2005 | Toxicol Rev2005，24，1： | 1 |
| 8 | Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal显示文摘 | MEAGHER L P BEECHER G R FLANAGAN V P | 1999 | Journal of Agriculture and Food Chemistry1999，47，8： | 1 |
| 9 | Multiple logistic regression analysis of plasma paraquat concentrations as predictor of outcome in 375 cases of paraquat poisoning显示文摘 | Jones Air Elton R Flanagan R | 1999 | QJM1999，92，10： | 1 |
| 10 | Multiple logistic regression analysis of plasma paraquat concentrations as a predictor of outcome in 375 cases of paraquat poisoning显示文摘 | Jones L Elton R Flanagan R | | 0，，： | 1 |
| 11 | Severe morbidity and mortality with breast milk associated eytomegalovirus infection显示文摘 | Hamele M Flanagan R Loomis CA | 2010 | Pediatr Infect Dis J2010，29，： | 1 |
| 12 | Measurement of nucleic acid concentrations using the DyNA Quant and the GeneQuant显示文摘 | Teare J M Islam R Flanagan R | 1997 | Bio Techniques1997，22，6： | 1 |
| 13 | Historical development of glycidyl azide polymer显示文摘 | Frankel M B Grant L R Flanagan J E | 1992 | Propulsion and Power1992，8，3： | 1 |
| 14 | foot-and-mouth disease virus from African buffalo to cattle in a wildlife area of Zimbabwe显示文摘 | Dawe P S Flanagan F O Madekurozwa R L | 1994 | Vet Rec1994，134，： | 1 |
| 15 | Finite element evaluation of hydrogen solubility enhancements due to thermal residual stresses in palladium-alumina composites显示文摘 | Dixit P M Balasubramaniam R Flanagan T B | 2003 | J Alloys and Compounds2003，，： | 1 |
| 16 | A Functional Data Analysis of the Pinch Force of Human Fingers 显示文摘 | Ramsay J O Wang X Flanagan R | 1995 | Journal of the Royal Statistical Society1995，44，1： | 1 |
| 17 | Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes显示文摘 | M(a)nnikk(o) R Flanagan SE Sim X | | 0，，06： | 1 |
| 18 | Storm pattern effect on nitrogen and phosphorus losses in surface runoff显示文摘 | Flanagan D C Foster G R | 1989 | Transactions of the ASAE1989，32，： | 1 |
| 19 | Carbon isotope composition of boreal plants: functional grouping of life forms显示文摘 | Brooks J R Flanagan L B Buchman N | 1997 | Oecologia1997，110，： | 1 |
| 20 | Constraining interactions in Cosmology's Dark sector显示文摘 | BEAN R FLANAGAN E E LASZLO I Trodden M | 2008 | Plays Rev D2008，78，2： | 1 |
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