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| 1 | Assessing Soil Erosion Rates on Manually-Tilled Hillslopes in the Sichuan Hilly Basin Using ^(137)Cs and ^(210)Pb_(ex) Measurements显示文摘Purple soils are widely distributed in the Sichuan Hilly Basin and are highly susceptible to erosion, especially on the cultivated slopes. Quantitative assessment of the erosion rates is, however, difficult due to small size of the plots of the manually-tilled land, the complex land use, and steep hillslopes. 137Cs and 210Pbex (excess 210Pb) tracing techniques were used to investigate the spatial pattern of soil erosion rates associated with slope-land under hoe tillage in Neijiang of the Sichuan Hilly Basin. The 137Cs and 210Pbex inventories at the top of the cultivated slope were extremely low, and the highest inventories were found at the bottom of the cultivated slope. By combining the erosion rates estimates provided by both 137Cs and 210Pbex measurements, the weighted mean net soil loss from the study slope was estimated to be 3100 t km-2 year'1, which was significantly less than 6930 t km-2 year-1 reported for runoff plots on a 10°cultivated slope at the Suining Station of Soil Erosion. The spatial pattern of soil erosion rates on the steep agricultural land showed that hoe tillage played an important role in soil redistribution along the slope. Also, traditional farming practices had a significant role in reducing soil loss, leading to a lower net erosion rate for the field. | ZHENG Jin-Jun HE Xiu-Bin D. WALLING ZHANG Xin-Bao D. FLANAGAN QI Yong- Qing | 2007 | Pedosphere2007，17，3： | 17 |
| 2 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 3 | Laparoscopic Colectomy for Cancer Is Not Inferior to Open Surgery Based on 5-Year Data From the COST Study Group Trial显示文摘 | James Fleshman Daniel J. Sargent Erin Green Mehran Anvari Steven J. Stryker Robert W. Beart Michael Hellinger Richard Flanagan Walter Peters Heidi Nelson | 2007 | Annals of Surgery2007，，4： | 7 |
| 4 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 5 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 6 | GLUTATHIONE TRANSFERASES显示文摘 | John D. Hayes Jack U. Flanagan Ian R. Jowsey | 2005 | Annual Review of Pharmacology and Toxicology2005，，： | 2 |
| 7 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 8 | Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease显示文摘Multiple studies have demonstrated alterations in the intestinal microbial community(termed the microbiome) in Crohn's disease(CD) and several lines of evidence suggest these changes may have a significant role in disease pathogenesis. In active and quiescent disease, both the faecal and mucosa-associated microbiome are discordant with matched controls with reduced biodiversity, changes in dominant organisms and increased temporal variation described. Mucosaassociated adherent, invasive Escherichia coli(E. coli)(AIEC), pro-inflammatory and resistant to killing by mucosal macrophages, appear to be particularly important. AIEC possess several virulence factors which may confer pathogenic potential in CD. Type-1 pili(FimH) allow adherence to intestinal cells via cell-surface carcinoembryonic antigen-related cell adhesion molecules and possession of long polar fimbrae promotes translocation across the intestinal mucosa via microfold(M)-cells of the follicle-associated epithelium. Resistance to stress genes(htrA, dsbA and hfq) and tolerance of an acidic pH may contribute to survival within the phagolysosomal environment. Here we review the current understanding of the role of mucosa-associated E. coli in Crohn's pathogenesis, the role of the innate immune system, factors which may contribute to prolonged bacterial survival and therapeutic strategies to target intracellular E. coli. | Ahmed Tawfik Paul K Flanagan Barry J Campbell | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 9 | Specific expression of the AGL1 MADS- box gene suggests regulatory functions in Arabidopsis gynoecium and ovule development显示文摘 | Flanagan C A Hu Y Ma H | 1996 | Plant J1996，，10： | 1 |
| 10 | A Method for Estimating the Nature and Relative Proportions of Amorphous, Single, and Double-Helical Components in Starch Granules by 13C CP/MAS NMR 显示文摘 | Ihwa Tan Bernadine M Flanagan | 2007 | Biomacromolecules2007，8，3： | 1 |
| 11 | Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity(ORAC)and ferric reducing antioxidant power(FRAP)assays:a comparative study显示文摘 | Ou B Huang D Hampsch-Woodill M Flanagan J A | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 12 | Endomet-rial CD56+ natural killer cells in women with recurrent miscarriage:a histomorphometric study显示文摘 | CLIFFORD K FLANAGAN AM REGAN L | 1999 | Hum Reprod1999，14，11： | 1 |
| 13 | BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals显示文摘 | Jette CA Flanagan AM Ryan J | 2008 | Cell Death Differ2008，15，6： | 1 |
| 14 | Dimorphic Plasmodium falciparum memzoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming显示文摘 | Lee EA Flanagan KL Minigo G etal | 2006 | Eur J Immunol2006，36，5： | 1 |
| 15 | Autodirective microphone systems显示文摘 | Flanagan J L Berkeley D A Elko G W | 1991 | Acoustics1991，73，3： | 1 |
| 16 | Antimicrobial activities of dental impression materials显示文摘 | Flanagan DA Palenik CJ Setcos JC | 1998 | Dent Mater1998，14，： | 1 |
| 17 | Utility of FDG- PET for investigating unexplained plasma CEA elevation in patients with colorectal cancer 显示文摘 | Flanagan FL Dehdashti F Ogunbiyi OA | 1998 | Ann Surg1998，227，3： | 1 |
| 18 | Genebody hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients显示文摘 | Flanagan JM Munoz-Alegre M Henderson S | 2009 | Hum Mol Genet2009，18，7： | 1 |
| 19 | Nogo domains and a Nogo receptor: implications for axon regeneration显示文摘 | Brittis P A Flanagan J G | 2001 | Neuron2001，30，1： | 1 |
| 20 | Storm pattern effect on nitrogen and phosphorus losses in surface runoff显示文摘 | Flanagan D C Foster G R | 1989 | Transactions of the ASA- BE1989，32，2： | 1 |
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