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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Particle-Imaging Techniques for Experimental Fluid Mechanics显示文摘 | R J Adrian | 1991 | Annual Review of Fluid Mechanics1991，，： | 3 |
| 3 | Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits. | Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 4 | 轮胎用橡胶的发展显示文摘 | Rüdiger Engehausen Adrian Rawlinson Jürgen Trimbach 涂学忠 | 2002 | 轮胎工业2002，22，9： | 2 |
| 5 | Three-dimensional vortex organization in a high-Reynolds-number supersonic turbulent boundary layer显示文摘 | Elsinga G E Adrian R J Van Oudheusden B W | 2010 | J Fluid Mech2010，644，： | 1 |
| 6 | The role of transforming growth factor-beta (TGF- beta) during ovarian follicular development in sheep 显示文摘 | JENNIFER L J ADRIAN H B KAREN L R | 2004 | Reproductive Biology and Endocrinology2004，2，： | 1 |
| 7 | Particle imaging techniques for experimental fluid mechanics显示文摘 | Adrian R J | 1991 | Annual Review of Fluid Mechanics1991，23，： | 1 |
| 8 | Multi-point optical measurements of simultaneous vectors in unsteady flow-a review显示文摘 | Adrian R J | 1986 | International Journal of Heat and Fluid Flow1986，7，2： | 1 |
| 9 | A Two-Phase Cinematic PIV Method for Bubbly Flows 显示文摘 | Oakley T R Loth E Adrian R J | 1997 | Journal of Fluids Engineering1997，，119： | 1 |
| 10 | Stereoscopic particle image velocimetry applied to liquid flows显示文摘 | PRASAD A K ADRIAN R J | 1993 | Experime- nts in Fluids1993，15，1： | 1 |
| 11 | Particle dispersion in isotropic turbulence under Stokes drag and Basset force with gravitational setting显示文摘 | MEI R W ADRIAN R J HANRATTY T J | 1991 | J Fluid Mech1991，225，： | 1 |
| 12 | Twenty years of particle image velocimetry显示文摘 | Adrian R J | 2005 | Exp Fluids2005，39，2： | 1 |
| 13 | On the relationships between local vortex identification schemes显示文摘 | Chakraborty P Balachandar S Adrian R J | 2005 | Journal of Fluid Mechanics2005，535，1： | 1 |
| 14 | Vortex organization in the outer region of the turbulent boundary layer 显示文摘 | Adrian R J Meinhart C D Tomkins C D | 2000 | Journal of Fluid Mechanics2000，，422： | 1 |
| 15 | Im- provements in Fixed-Valve micropump performance through shape optimization of valves 显示文摘 | Adrian R Gamboa Christopher J Morris and Fred K Forster | 2005 | Journal of Fluids Engineering2005，127，2： | 1 |
| 16 | Structure of the Crypto- sporidium parvum microneme:a metabolically and osmotically labile apieomplexan organelle显示文摘 | Harris J R Adrian M Petry F | 2003 | Micron2003，34，： | 1 |
| 17 | Mechanisms for generating coherent packets of hairpin vortices in channel flow 显示文摘 | Zhou J Adrian R J Balachandar S | 1999 | Journal of Fluid Mechanics1999，387，： | 1 |
| 18 | Magnetic signature of daily sampled urban atmospheric particles 显示文摘 | Adrian R Muxworthy J urgen Matzka Alfonso Fernandez Davila | 2003 | Atmospheric Environment2003，37，： | 1 |
| 19 | Twenty years of particle image velocimetry显示文摘 | Adrian R J | 2005 | Experiments in Fluids2005，39，： | 1 |
| 20 | Transition from laminar to turbulent flow in liquid fdled microtubes显示文摘 | SHARP K V ADRIAN R J | 2004 | Experiments in Fluids2004，36，5： | 1 |
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