| 2 | MK-287的对映选择性合成显示文摘錝,5″S)-2-{3′-Methoxy-2′-propoxy-5′-[5″-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2″-yl] phenylsulfonyl}ethanol(MK-287) which was potent PAF antagonist, was enantioselectively synthesized in eight steps by addition, oxidation, hot decomposition, hydrogenation and so on from (-)-4,10-dioxatricyclo-[5.2.1.0 2,6]-decene-3-ole(1). Asymmetry was introduced using the nucleophilic addition of the triisopropoxytitanium to the lactol 1. The second asymmetric center was installed by a highly stereocontrolled acid-assisted reduction with sodium cyanoborohydride of the hemiketal formed. The product MK-287 was optically pure. | 史鸿鑫 林辉 R.Bloch G.Mandville | 2004 | 高等学校化学学报2004，25，5： | 0 |
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