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| 1 | Investigating neurogenic bowel in experimental spinal cord injury: where to begin?显示文摘The devastating losses following traumatic spinal cord injury(SCI) encompass the motor, sensory and autonomic nervous systems. Neurogenic bowel is a slow transit colonic dysfunction marked by constipation, rectal evacuation difficulties, decreased anorectal sensation, fecal incontinence or some combination thereof. Furthermore, neurogenic bowel is one of the most prevalent comorbidities of SCI and is recognized by afflicted individuals and caregivers as a lifelong physical and psychological challenge that profoundly affects quality of life. The restoration of post-injury control of movement has received considerable scientific scrutiny yet the daily necessity of voiding the bowel and bladder remains critically under-investigated. Subsequently, physicians and caregivers are rarely presented with consistent, evidence-based strategies to successfully address the consequences of dysregulated voiding reflexes. Neurogenic bowel is commonly believed to result from the interruption of the supraspinal control of the spinal autonomic circuits regulating the colon. In this mini-review, we discuss the clinical challenges presented by neurogenic bowel and emerging pre-clinical evidence that is revealing that SCI also initiates functional remodeling of the colonic wall concurrent with a decrease in local enteric neurons. Since the enteric input to the colonic smooth muscle is the final common pathway for functional contractions of the colon, changes to the neuromuscular interface must first be understood in order to maximize the efficacy of therapeutic interventions targeting colonic dysfunction following SCI. | Amanda R.White Gregory M.Holmes | 2019 | Neural Regeneration Research2019，14，2： | 4 |
| 2 | Parametric randomization‐based methods for correcting for treatment changes in the assessment of the causal effect of treatment显示文摘 | A. SarahWalker Ian R.White Abdel G.Babiker | 2004 | Statist Med2004，，4： | 1 |
| 3 | Randomization‐based methods for correcting for treatment changes: examples from the Concorde trial显示文摘 | Ian R.White Abdel G.Babiker SarahWalker Janet H.Darbyshire | 1999 | Statist Med1999，，19： | 1 |
| 4 | 盈利能力分析显示文摘为支持整个组织发展并驱动价值创造,我们需要从新的角度重新审视财务规划与分析。在网上搜索财务规划和分析(FP&A),会弹出很多定义。一些定义将FP&A理解为财务报告中的月度、季度及年度预算与规划;另一些将其看作战略规划、运营规划、资本规划与费用规划等一系列不同角度的规划集。这些搜索反映出一个事实,即我们都在寻找财务规划和分析的最佳实践,谁是领导者?他们把什么做得很好?又为什么有这么多公司在为此苦苦挣扎? | Larry R.White Raef Lawson | 2019 | 新理财(公司理财)2019，0，10： | 1 |
| 5 | Micro-ESR:微型电子自旋共振光谱仪显示文摘电子自旋共振光谱(ESR),又称顺磁共振光谱(EPR),是直接检测自由基、引起石油氧化降解含有未成对电子的活性分子以及食物的唯一方法,也在生物化学研究疾病方面起着一定的作用。本文所描述的微型、高灵敏度的ESR光谱仪通过显著降低光谱技术的成本,能够为工业和科学研究者扩大ESR光谱学的实用范围。 | Christopher J.WHITE Colin T.ELLIOTT James R.WHITE | 2011 | 生命科学仪器2011，9，3： | 1 |
| 6 | Association of olfactory dysfunction with risk for future Parkinson’s disease显示文摘 | G. WebsterRoss HelenPetrovitch Robert D.Abbott Caroline M.Tanner JordanPopper KamalMasaki LenoreLauner Lon R.White | 2008 | Ann Neurol2008，，2： | 1 |
| 7 | 过去的金融危机、当前的金融动荡与新宏观金融稳定框架的需要显示文摘尽管在帮助解释最近的金融动荡时,人们试图集中于新的金融创新。但是,传统的原因也不能忽略。正如之前的许多案例所表明的那样,信贷快速增长导致资产价格的大部分增加,而反过来鼓励了被证明不可维续的消费和投资决策。金融系统的亲周期性特征或许应包含引进'新的宏观金融稳定框架'。许多实践措施可以实现这一建议,但也有理由相信这些措施应该被清除。 | William R.White(著) 潘再见(译) | 2009 | 经济资料译丛2009，，1： | 1 |
| 8 | Carbon Finance : The Financial Implications of Climate Change显示文摘 | John Wiley S i nia Labatt Rodney R.White | | 0，，： | 1 |
| 9 | Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases显示文摘Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and in vivo rodent models lacked scalability, consistency, or physiological relevance, which deterred successful therapeutic outcomes for the past decade. Here we review human blood monocyte-derived microglia-like cells as a robust and consistent approach to generate a patient-specific microglia-like model that can be used in extensive cohort studies for drug testing. We will highlight the strength and applicability of human blood monocyte-derived microglia-like cells to increase translational outcomes by reviewing the advantages of human blood monocyte-derived microglia-like cells in addressing patient heterogeneity and stratification, the basis of personalized medicine. | Hazel Quek Anthony R.White | 2023 | Neural Regeneration Research2023，18，5： | 1 |
| 10 | Predictors of a true complete response among disappearing liver metastases from colorectal cancer after chemotherapy显示文摘 | Rebecca C.Auer Rebekah R.White Nancy E.Kemeny Lawrence H.Schwartz JinruShia Leslie H.Blumgart Ronald P.DeMatteo YumanFong William R.Jarnagin Michael I.D’Angelica | 2010 | Cancer2010，，6： | 1 |
| 11 | Wind-tunnel and field investigation of the effect of local wind direction on speed-up over hills显示文摘 | Lubitz W D Bruce R.White | | 0，，08： | 1 |
| 12 | 数字时代:会计人员面临新挑战显示文摘颠覆性技术正在越来越快地改变会计实践,这使得会计职业与其他许多行业一样,面临着挑战。机器学习和机器人自动化等技术正在消除对初级职位的需求,很快这些技术及其他数码工具将会使更高级别的职位变得多余。这就让管理会计师未来的角色定位变得不明朗。 | Raef Lawson Larry R.White | 2018 | 新理财(公司理财)2018，0，9： | 0 |
| 13 | 基于AI技术的企业决策分析显示文摘信息数字化背景下,管理会计师可运用人工智能(AI)提供的具有因果关系的实时信息,提高决策支持能力。本文阐述了AI技术对企业决策支持所发挥的具体作用,同时对用于创建AI能力以提供财务和决策支持的三类通用工具进行了具体阐述,希望能对数字化时代下企业AI技术的应用提供借鉴和参考。 | Anton van der Merwe Larry R.White | 2021 | 管理会计研究2021，，3： | 0 |
| 14 | AI:企业决策分析显示文摘数字时代,管理会计师和财务部门的增值点在哪里?在这个数字化的世界里,用于支持内部决策的独立的成本模型不再是一项增值资产,数字孪生因果模型的出现,将使得以方法为中心的成本核算模式(如作业成本法及以财务报告为导向的标准成本法)不再适用于决策支持。 | Anton van der Merwe Larry R.White | 2021 | 新理财(公司理财)2021，，6： | 0 |
| 15 | DISTRIBUTION AND CHARACTERIZATION OF NON-VOLATILE CHEMICAL MUTAGENS IN SEDIMRNTS OF AN INDUSTRIALLY IMPACTED RIVER显示文摘A coupled bioassay/analytical fractionation approachwas used to isolate genotoxic contaminants from riversediments collected at points upstream,adjacent to,and downstream from centers of major industrial andmunicipal activities.Sediments were milled withsodium sulfate and sequentially extracted with anonpolar to polar solvent series;extracts | M.Wilson Tabor Marcus C.Waldron Alan R.White | 1991 | 癌变.畸变.突变1991，3，S1： | 0 |
| 16 | A scoping review of randomized clinical trials for pain management in pediatric tonsillectomy and adenotonsillectomy显示文摘Objectives:To examine the volume,topics,and reporting trends in the published literature of randomized clinical trials for pharmacologic pain management of pediatric tonsillectomy and adenotonsillectomy and to identify areas requiring further research.Data Sources:PubMed(National Library of Medicine and National Institutes of Health),Scopus(Elsevier),CINAHL(EBSCO),and Cochrane Library(Wiley).Methods:A systematic search of four databases was conducted.Only randomized controlled or comparison trials examining pain improvement with a pharmacologic intervention in pediatric tonsillectomy or adenotonsillectomy were included.Data collected included demographics,pain-related outcomes,sedation scores,nausea/vomiting,postoperative bleeding,types of drug comparisons,modes of administration,timing of administration,and identities of the investigated drugs.Results:One hundred and eighty-nine studies were included for analysis.Most studies included validated pain scales,with the majority using visual-assisted scales(49.21%).Fewer studies examined pain beyond 24 h postoperation(24.87%),and few studies included a validated sedation scale(12.17%).Studies have compared several different dimensions of pharmacologic treatment,including different drugs,timing of administration,modes of administration,and dosages.Only 23(12.17%)studies examined medications administered postoperatively,and only 29(15.34%)studies examined oral medications.Acetaminophen only had four self-comparisons.Conclusion:Our work provides the first scoping review of pain and pediatric tonsillectomy.With drug safety profiles considered,the literature does not have enough data to determine which treatment regimen provides superior pain control in pediatric tonsillectomy.Even common drugs like acetaminophen and ibuprofen require further research for optimizing the treatment of posttonsillectomy pain.The heterogeneity in study design and comparisons weakens the conclusions of potential systematic reviews and meta-analyses.Future directions include more noninferiority studies of unique comparisons and more studies examining oral medications given postoperatively. | Michael C.Shih Barry D.Long Phayvanh P.Pecha David R.White Yi-Chun C.Liu Brennan Emily Mariam I.Nguyen Clarice S.Clemmens | 2023 | World Journal of Otorhinolaryngology-Head and Neck Surgery2023，9，1： | 0 |
| 17 | Ferroptosis drives immune-mediated neurodegeneration in multiple sclerosis显示文摘One of the leading issues in multiple sclerosis(MS)research is the lack of understanding regarding the triggers of neurodegeneration.While demyelination is a major feature in MS,the degeneration of gray matter neurons contributes to major changes in patient function,but the mechanisms driving this neuronal loss are unknown.In exciting research published by Luoqian et al.[1]in the December issue of Cellular and Molecular Immunology,new insights have shown an important contribution of ferroptosis to T-cell-mediated neurodegeneration in the common animal model of MS,‘experimental autoimmune encephalomyelitis’(EAE).Although a relationship between ferroptosis and T-cell activation has been reported in other disorders,this is the first discovery of a link between abnormal iron homeostasis and T-cell infiltration in MS.In addition,the authors found that unlike other studies on ferroptosis-T-cell interactions[2,3],ferroptotic activation of T cells in EAE,and potentially MS,involved the infiltration and activation of CD4+T cells,rather than CD8+cells.Moreover,in this study,ferroptosis was a key driver of T-cell activation rather than the opposite interaction where CD8+cells drive ferroptosis[3].The research also mapped a key role for Acsl4 in the early stages of ferroptosis-T-cell-mediated neurodegeneration.Acsl4 converts free long-chain fatty acids into fatty acyl-CoA esters and has been identified as a central contributor to ferroptotic processes[4].This study has mapped a major new pathway potentially leading to neurodegeneration in MS,and this opens the possibility of new therapeutic approaches to treat MS based on iron targeting as the authors describe in their final experiments. | Anthony R.White | 2023 | Cellular & Molecular Immunology2023，20，1： | 0 |
| 18 | A transgenic pig model expressing a CMV-ZsGreen1 reporter across an extensive array of tissues显示文摘Since genetic engineering of pigs can benefit both biomedicine and agriculture,selecting a suitable gene promoter is critically important.The cytomegalovirus(CMV)promoter,which can robustly drive ubiquitous transgene expression,is commonly used at present,yet recent reports suggest tissue-specific activity in the pig.The objective of this study was to quantify ZsGreen1 protein(in lieu of CMV promoter activity)in tissues from pigs harboring a CMV-ZsGreen1 transgene with a single integration site.Tissue samples(n=35)were collected from neonatal hemizygous(n=3)and homozygous(n=3)piglets and ZsGreen1 abundance was determined via immunoblotting.ZsGreen1 was detected in all tissues,except hypothalamus,kidney cortex and oviduct.The expression patterns of homozygous and hemizygous piglets were similar(P>0.05).However,quantification revealed that ZsGreen1 protein levels were tissue-specific.Within neural/endocrine tissues,ZsGreen1 abundance was highest in the anterior pituitary gland,intermediate in the cerebellum and lowest in the cerebrum,spinal cord and posterior pituitary(P<0.05).In the digestive system,ZsGreen1 was more abundant in the salivary gland than esophagus,stomach,pancreas,duodenum,jejunum,ileum,spleen,colon,gallbladder and liver(P<0.05).Interestingly,ZsGreen1 amounts also differed within an organ(i.e.,the right ventricle had 3-fold higher levels than the other heart chambers;P<0.05).These results provide useful information for the use of the CMV promoter to drive transgene expression in the pig.Moreover,this swine model represents a novel resource of ZsGreen1-labeled organs and a valuable tool to advance genome editing research. | Amy T.Desaulniers Rebecca A.Cederberg Elizabeth P.Carreiro Channabasavaiah B.Gurumurthy Brett R.White | 2021 | The Journal of Biomedical Research2021，35，2： | 0 |
| 19 | 数字化制造与CFO显示文摘数字化制造企业中的CFO和财务部门面临各种各样的挑战和机会。这些变化可能逐步发生,也可能会相当快地发生,关键在于要认识和接受变化而非忽视和对抗变化。哪些方面会发生变化呢?简单来说,一切都可能发生变化。但让我们来审视以下几个具体领域并分享一些见解,以便财务部门能够更有效地适应和响应组织需求。 | Larry R.White Todd D.Simon John Jackiw | 2019 | 新理财(公司理财)2019，0，7： | 0 |
| 20 | Impact of early eyelid weight placement on the development of synkinesis and recovery in patients with idiopathic facial paralysis显示文摘Determine the impact of upper eyelid weight placement at 3 months post onset of idiopathic facial paralysis(IFP)on the recovery of facial function in patients with lagophthalmos.Methods:This is a retrospective review of patients with incomplete recovery of IFPddefined as a Sunnybrook Facial Grading Scale(FGS)score of less than 100,3 months after onset.Only patients with FGS and Facial Clinimetric Evaluation(FaCE)scores recorded at 3 and 12 months were included.Patients were categorized into 3 groups:Group A,lagophthalmos with eyelid weight placement;Group B,lagophthalmos without eyelid weight placement;Group C,complete eye closure(CEC)without eyelid weight placement.The eye comfort domain and composite score of the FaCE questionnaire were analyzed.Voluntary eye closure,synkinesis with eye closure,overall synkinesis and the composite score of the FGS were also analyzed.Paired two-tailed t-test was used to evaluate the data comparing the 3 and 12 month FaCE and FGS scores within and between the 3 groups.Results:The change in composite FGS score significantly increased from month 3 to month 12 in Group A as compared to Group B(37 vs 4.25,P=0.01).While Group A had significantly lower eye comfort(-12.5,P=0.01),voluntary eye closure(-1.75,P=0.05)and overall FGS scores(-28.75,P=0.04)at 3 months compared to those in Group C,there were no differences between these two groups at 12 month follow-up.Conclusions:For patients with lagophthalmos at 3 months,early eyelid weight placement may lead to improved facial function at 12 months. | Keon M.Parsa Caroline Rieger Dara Khati Jennifer R.White Jodi Barth Chad C.Zatezalo Michael J.Reilly | 2021 | World Journal of Otorhinolaryngology-Head and Neck Surgery2021，7，4： | 0 |
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