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| 1 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Optimal selection of ensemble classifiers using measures of competence and diversity of base clas- sifiers 显示文摘 | RAFAL L MAREK K TOMASZ W | 2014 | Neurocomputing2014，，： | 1 |
| 3 | Dietary supplementation with phytohemagglutinin in combination withα-ketoglutarate limits the excretion of nitrogen via urinary tract显示文摘 | Rafal F Leszek W Adrian P | 2008 | Ann Agric Environ Med2008，，15： | 1 |
| 4 | Structure and properties of Ni-Mn-Ga magnetic shape memory alloys containing minor addition of terbium显示文摘 | RAFAL W MARCIN L ZHAO Zeng-qi JIANG Li-ping | 2007 | Journal of Magnetism and Magnetic Materials2007，316，： | 1 |
| 5 | Human health risk assessment case study: an abandoned metal smelter site in Poland显示文摘 | ELEONORA W DAWN I RAFAL K | 2002 | Chemosphere2002，47，： | 1 |
| 6 | Robust autopilot for a quasi-linear parameter-varying vehicle model 显示文摘 | ANTONIOS T RAFAL Z BRAIN A W | 2001 | Journal of Guidance Control and Dynamics2001，24，2： | 1 |
| 7 | Human health risk assessment case study: An abandoned metal smelter site in Poland显示文摘 | ELEONORA W DAWN I RAFAL K | 2002 | Chemosphere2002，，47： | 1 |
| 8 | Human health risk assessment case study: an abandoned metal smelter site in Poland显示文摘 | ELE0NORA W DAWN I RAFAL K et a1 | 2002 | Chemosphere2002，47，： | 1 |
| 9 | Human Heal Thrisk Assessment Case sutdy: Anabandoned Metal Smel Tersite in Poland显示文摘 | Eleonora W Dawnl Rafal K | 2000 | Chemosphere2000，47，20： | 1 |
| 10 | Human health risk assessment case study:an abandoned metal smelter site in Poland显示文摘 | ELEONORA W DAWN I RAFAL K | 2002 | Chemosphere2002，，47： | 1 |
| 11 | Human health risk assessment case study:an abandoned metal smelter site in Poland显示文摘 | ELEONORA W DAWN I RAFAL K | 2002 | Chemosphere2002，，47： | 1 |
| 12 | Human health risk assessment case study: an abandoned metal smelter site in Poland 显示文摘 | ELEONORA W DAWN I RAFAL K | 2002 | Chemosphere2002，47，： | 1 |
| 13 | On the chambers-mallows-stuck method for simulating skewed stable random vairables显示文摘 | RAFAL W | 1996 | Statistics & Probability Letter1996，28，2： | 1 |
| 14 | Probing noncovalent interaction in biomolecular crystals with terahertz spectroscopy 显示文摘 | Thomas K O Rafal W Frank R | 2008 | Chem Phys Chem2008，9，4： | 1 |
| 15 | Influence of modified starches on properties of gluten - free dough and bread 显示文摘 | MARIUSZ W LESLAW J RAFAL Z | 2012 | Food Hydrocolloids2012，，28： | 1 |
| 16 | Saccade preparation inhibits reorienting to recently attended locations 显示文摘 | Rafal R D Calabresi P A Brennan C W | 1989 | Journal of Experimental Psychology: Human Perception and Performance1989，15，4： | 1 |
| 17 | Out- come in primary cemented total knee ar- throplasty with or without drain: A pros- pective comparative study显示文摘 | Rafal K Paradowski TP Dariusz W | 2014 | Indian J Or- thop2014，48，4： | 1 |
| 18 | Best therapy for the easiest to treat hepatitis C virus genotype 1binfected patients显示文摘BACKGROUND The revolution in treatment of patients with chronic hepatitis C virus(HCV)infection dates back to the introduction of direct-acting antivirals(DAAs).The increase in efficacy was most pronounced in patients infected with genotype(GT)1b,as this was the most poorly responsive population to treatment during the interferon era.AIM To identify the most effective interferon-free therapy for GT1b-infected patients and to determine positive and negative predictors of virological response.METHODS This real-world retrospective analysis included patients chronically infected with GT1b HCV whose data were obtained from the multicenter observational EpiTer-2 database.Treatment effectiveness was evaluated for each therapeutic regimen as the percentage of sustained virological responses(SVR).Assessment of the safety was based on the evaluation of the course of therapy,the occurrence of adverse events including serious ones,deaths during treatment and in the post 12-wk follow-up period.RESULTS The studied population consisted of 11385 patients with a mean age of 53±14.8 years and a female predominance(53.4%).The majority of them were treatment-naïve(74.6%)and patients with cirrhosis accounted for 24.3%.Of the DAA regimens used,76.9%were GT-specific with ombitasvir/paritaprevir/ritonavir+dasabuvir±ribavirin being the most used option(32.4%).A total of 10903 patients responded to treatment resulting in a 98.1%in the per-protocol analysis after excluding 273 patients without SVR data.The effectiveness of all regimens exceeded 90%and the highest SVR of 98.9%was achieved in patients treated with a combination of glecaprevir/pibrentasvir.Logistic regression analyses showed that the virologic response was independently associated with female sex[odds ratio(OR)=1.67],absence of decompensated cirrhosis at baseline(OR=2.42)and higher baseline platelets(OR=1.004 per 1000/μL increase),while the presence of human immunodeficiency virus(HIV)coinfection significantly decreased the odds of response(OR=0.39).About 95%-100%of patients completed therapy irrespective of the drug regimen.At least one adverse effect occurred in 10.9%-36.3%and most of them were mild.No treatment related deaths have been reported.CONCLUSION We documented very high effectiveness and a good safety profile across all DAA regimens.Positive predictors of SVR were female sex,absence of decompensated cirrhosis at baseline and higher platelet count while HIV coinfection reduced the effectiveness. | Dorota Zarębska-Michaluk Michal Brzdęk Jerzy Jaroszewicz Magdalena Tudrujek-Zdunek Beata Lorenc Jakub Klapaczyński Włodzimierz Mazur Adam Kazek Marek Sitko Hanna Berak Justyna Janocha-Litwin Dorota Dybowska Łukasz Supronowicz Rafal Krygier Jolanta Citko Anna Piekarska Robert Flisiak | 2022 | World Journal of Gastroenterology2022，28，45： | 0 |
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