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| 1 | Histopathological differences utilizing the nonalcoholic fatty liver disease activity score criteria in diabetic(type 2 diabetes mellitus) and non-diabetic patients with nonalcoholic fatty liver disease显示文摘AIM: To study clinical and histopathological features of nonalcoholic fatty liver disease(NAFLD) in patients with and without type 2 diabetes mellitus(T2DM) using updated nonalcoholic steatohepatitis clinical research network(NASH-CRN) grading system.METHODS: We retrospectively analyzed data of 235 patients with biopsy proven NAFLD with and without T2 DM.This database was utilized in the previously published study comparing ethnicity outcomes in NAFLD by the same corresponding author.The pathology database from University of Chicago was utilized for enrolling consecutive patients who met the criteria for NAFLD and their detailed clinical and histopathology findings were obtained for comparison.The relevant clinical profile of patients was collected from the Electronic Medical Records around the time of liver biopsy and the histology was read by a single well-trained histopathologist.The updated criteria for type 2 diabetes have been utilized for analysis.Background data of patients with NASH and NAFLD has been included.The mean differences were compared using χ2 and t-test along with regression analysis to evaluate the predictors of NASH and advanced fibrosis.RESULTS: Patients with NAFLD and T2 DM were significantly older(49.9 vs 43.0,P < 0.01),predominantly female(71.4 vs 56.3,P < 0.02),had higher rate of metabolic syndrome(88.7 vs 36.4,P < 0.01),had significantly higher aspartate transaminase(AST)/alanine transaminase(ALT) ratio(0.94 vs 0.78,P < 0.01) and Fib-4 index(1.65 vs 1.06,P < 0.01) as markers of NASH,showed higher mean NAFLD activity score(3.5 vs 3.0,P = 0.03) and higher mean fibrosis score(1.2 vs 0.52,P < 0.01) compared to patients with NAFLD without T2 DM.Furthermore,advanced fibrosis(32.5 vs 12.0,P < 0.01) and ballooning(27.3 vs 13.3,P < 0.01) was significantly higher among patients with NAFLD and T2 DM compared to patients with NAFLD without T2 DM.On multivariate analysis,T2 DM was independently associated with NASH(OR = 3.27,95%CI: 1.43-7.50,P < 0.01) and advanced fibrosis(OR = 3.45,95%CI: 1.53-7.77,P < 0.01) in all patients with NAFLD.There was a higher rate of T2DM(38.1 vs 19.4,P < 0.01) and cirrhosis(8.3 vs 0.0,P = 0.01) along with significantly higher mean Bilirubin(0.71 vs 0.56,P = 0.01) and AST(54.2 vs 38.3,P < 0.01) and ALT(78.7 vs 57.0,P = 0.01) level among patients with NASH when compared to patients with steatosis alone.The mean platelet count(247 vs 283,P < 0.01) and high-density lipoprotein cholesterol level(42.7 vs 48.1,P = 0.01) was lower among patients with NASH compared to patients with steatosis.CONCLUSION: Patients with NAFLD and T2 DM tend to have more advanced stages of NAFLD,particularly advanced fibrosis and higher rate of ballooning than patients with NAFLD without T2 DM. | Bharat K Puchakayala Siddharth Verma Pushpjeet Kanwar John Hart Raghavendra R Sanivarapu Smruti R Mohanty | 2015 | World Journal of Hepatology2015，7，25： | 10 |
| 2 | Tunneling,propping and expropriation:evidence from connected party transactions in Hong Kong显示文摘 | Cheung Y L Raghavendra R P Stouraitis A | 2006 | Journal of Financial Economics2006，82，： | 1 |
| 3 | Exploiting Hopping Pilots for Parametric Channel Estimation in OFDM Systems显示文摘 | RAGHAVENDRA M R BHASHYAM S | 2008 | IEEE Signal Processing Letters2008，12，11： | 1 |
| 4 | Improving channel estima- tion in OFDM systems for sparse muhipath channels 显示文摘 | Raghavendra M R Giridhar K | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 5 | Improving channel estimation in OFDM systems for sparse muhipath channels显示文摘 | RAGHAVENDRA M R GIRIDHAR K | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 6 | Improving channel estimation in OFDM systems for sparse multipath channels显示文摘 | RAGHAVENDRA M R GIRIDHAR K | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 7 | An investigation of co-fired varistor-ferrite materials 显示文摘 | Rafferty A Gun'ko Y Raghavendra R | 2004 | J Eur Ceram Soc2004，24，7： | 1 |
| 8 | Formulation and in-vitro evaluation of novel starch-based tableted microspheres for control-led release of ampicillin显示文摘 | Raghavendra C M Namdev B S Ajit P R | 2008 | Carbohydrat Poly- mers2008，71，1： | 1 |
| 9 | The impact of global elevated CO2 concentration on photosynthesis and plant productivity显示文摘 | REDDY A R RASINENI G K RAGHAVENDRA A S | 2010 | Current Science2010，99，1： | 1 |
| 10 | Human behavior analysis in video surveillance: A social signal processing perspective 显示文摘 | CRISTANI M RAGHAVENDRA R ALESSIO D B | 2013 | Neurocom- puting2013，100，2： | 1 |
| 11 | Grinding haracteristics and hydration properties of coconut residue: A source of dietary fiber显示文摘 | Raghavendra S N Ramachandra Swamy S R Raghavarao K S | 2006 | Journal of food engineering2006，72，： | 1 |
| 12 | Effects of degree of milling on water absorption of rice during cooking显示文摘 | Desikachar Raghavendra R S N Nnnathachar T K | 1965 | Food Sci Technol1965，11，： | 1 |
| 13 | Channelestimation for pseudo-random tile-allocation in uplink OFDMA显示文摘 | Raghavendra M R Lior E Bhashyam S | 2007 | IEEE Trans on Signal Processing2007，55，11： | 1 |
| 14 | Grinding characteristics and hydration properties of coconutresidue : A source of dietary fiber显示文摘 | Raghavendra S N Ramachandra Swamy S R Rastogi N K | 2006 | Journal of Food Engineering2006，77，： | 1 |
| 15 | Improving channel estimation in OFDM systems for sparse multipath channels 显示文摘 | Raghavendra M R Giridhar K | 2005 | IEEE Signal Processing Letters2005，12，1： | 1 |
| 16 | Effects of a yoga program on cortisol rhythm and mood states in early breast cancer patients undergoing adjuvant radiotherapy: A randomized controlled trial显示文摘 | Vadiraja HS Raghavendra RM Nagarathna R | 2009 | Integr Cancer Ther2009，8，1： | 1 |
| 17 | Yeast cytochrome C is a sequence-specific DNA-binding protein 显示文摘 | Bhatnagar A Raghavendra P R Kranthi B V Rangarajan P N | 2004 | Biochem Biophys Res Commun2004，321，4： | 1 |
| 18 | Hemimegaleneephalic appearance of normal hemispherein unilateral heterotopia and absent corpus callosum显示文摘 | Raghavendra S Krishnamoorthy T Ashalatha R | 2006 | Epilepsy Behav2006，9，2： | 1 |
| 19 | Spice active principles as the inhibi- tots of human platelet aggregation and thromboxane biosynthesis 显示文摘 | Raghavendra R Naidu K A | 2009 | Prostag Leukotr Ess2009，81，1： | 1 |
| 20 | Grinding characteristics and hydration properties of coconut residue: A source of dietary tiber 显示文摘 | Raghavendra S N Swamy S R Rastogi N K | 2006 | Journal of Food Engineering2006，72，： | 1 |
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