|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Characterization of novel glucose oxysilane sol-gel electrochemical biosen- sots with copper hexaeyanoferrate mediator 显示文摘 | Rasa Pauliukaite Christopher M A Brett | 2005 | Electro- chim Acta2005，50，2526： | 1 |
| 3 | 显示文摘 | Doina Bica Vekais L Rasa M | 2002 | J Magn Magn Mater2002，252，： | 1 |
| 4 | Shrinkage properties of differently managed clay soils in Finland显示文摘 | Rasa K Horn R Raty M | 2009 | Soil Use Manage2009，25，2： | 1 |
| 5 | Purification and characterization of endo- and exo-inulinase显示文摘 | ALDO M SZLAK | 1989 | Biotechnol Appl Biochem1989，11，： | 1 |
| 6 | Heteroaggregation,repepti-zation and stability in mixtures of oppositely charged colloids显示文摘 | Rasa M Philipse A Meeldijk J | 2004 | Journal of Colloid and Interface Science2004，278，1： | 1 |
| 7 | Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease 显示文摘 | Rasa M Fichtlscheres S Aicher A | 2001 | Cir Res2001，89，1： | 1 |
| 8 | Atomic force microscopy and magnetic force microscopy study of model colloids 显示文摘 | Rasa M Kuipers B W M Philipse A P | 2002 | Journal of Colloid and Interface Science2002，250，2： | 1 |
| 9 | Agglomerate formation in moderately concentrated ferrofluids from static magneto-optical measurements显示文摘 | SOCOLIUC V RASA M SOFONEA V | 1999 | J Magn Magn Mater1999，191，12： | 1 |
| 10 | Pancreatic cancer and glucose metabolism显示文摘 | Saru M Karaarslan M Rasa K | 2009 | Turk J Gastroenterol2009，20，4： | 1 |
| 11 | Preparation and magnetic properties of concentrated magnetic fluids on alcohol and water carrier liquids显示文摘 | Bica D Vekas L Rasa M | 2002 | J Magnet Magnt Mater2002，252，： | 1 |
| 12 | Thalidom ide produces trantsfusion in fependence in long-standing refractory anemias of potientd with myelodysplastic syndromes显示文摘 | Rasa A M E eye P Dutt D | 2001 | Blood2001，98，4： | 1 |
| 13 | Number and migratory activity of circulating endothelial progenitor cells in versely, correlate with risk factors for coronary artery disease显示文摘 | Rasa M Fichtlscheres S AicherA | 2001 | CirRes2001，89，： | 1 |
| 14 | Agglomerate formation in moderately concentrated ferrofluids from static magneto-op- tical measurements显示文摘 | Socoliuc V Rasa M Sofonea V | 1999 | Magnetism and Magnetic Materials1999，191，12： | 1 |
| 15 | A pilot double-blind placebo- controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism 显示文摘 | Ghaleiha A Rasa SM Nikoo M | 2015 | Psychiatry Res2015，229，12： | 1 |
| 16 | Agglomerate Formation in Moderately Concentrated Ferrofluids From Static Magneto-Optical Measurement 显示文摘 | Socoliuc V Rasa M Sofonea V | 1999 | J Magn Magn Mater1999，191，： | 1 |
| 17 | An improved biosensor for acetaldehyde determination using a bienzymatic strategy at poly(neutral red)modified carbon film electrodes显示文摘 | Mariana E G Rasa P Nicolas M | 2007 | Anal Chim Acta2007，591，1： | 1 |
| 18 | Improved Formulas for Magneto-Optical Measurement 显示文摘 | Rasa M | 1999 | J Magn Magn Mater1999，201，： | 1 |
| 19 | Agglomerate Formation in Moderately Concentrated Ferrofluids from Static Magneto-optical Measurements 显示文摘 | SOCOLIUC V RASA M SOFONEA V | 1999 | Journal of Magnetism and Magnetic Materials1999，191，12： | 1 |
| 20 | Exper imental and theoretical study of surface tension of n-pentane, n-heptane, and some of their mixtures ;tt different temperatures 显示文摘 | MOHSEN-NIA M RASA H NAGHIBI S F | 2010 | Journal of Chemical Ther modynamics2010，42，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员