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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Competency assessment: methods for development and implementation in nursing education 显示文摘 | Redman R W Lenburg C B Hinton Walker P | 1999 | Online Journal of Issues in Nursing1999，4，2： | 1 |
| 3 | Complexity of coupled human and natural systems显示文摘 | Liu J Dietz T Carpenter SR Alberti M Folke C Moran E Pell AN Deadman P Kratz T Lubchenco J Ostrom E Ouyang Z Provencher W Redman CL Schneider SH Taylor WW | 2007 | Science2007，317，： | 1 |
| 4 | Preeclampsia:an excessive maternal inflammatory response to pregnancy显示文摘 | Christopher WG Redman MD Gavin P | 1999 | Am J Obstet Gynecol1999，180，： | 1 |
| 5 | Disease control rate at 8 weeks predicts clinical benefit in advanced non-small-cell lung cancer:results from Southwest Oncology Group randomized trials显示文摘 | Lara P N Jr Redman M W Kelly K | 2008 | J Clin Oncol2008，26，3： | 1 |
| 6 | Evaluation of the preservation of shrimp samples with Davidson's AFA fixative for infectious myonecrosis virus(IMNV)in situ hybridization显示文摘 | Andrade T P D Redman R M Lightner D V | 2008 | Aquaculture2008，，278： | 1 |
| 7 | Preeclampsia: an excessive maternal inflammatory response to pregnancy 显示文摘 | Redman C W Sacks G P Sargent I L | 1999 | AmJ Obstet Gynecol1999，180，3： | 1 |
| 8 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Lo Y M Corbetta N Chamberlain P F Rai V Sargent I L Redman C N | 1997 | Lancet1997，350，： | 1 |
| 9 | Using a real-options approach to model technology adoption under carbon price uncertainty: an application to the Australian electricity generation sector 显示文摘 | COOMBES P GRAHAM P REDMAN L | 2006 | The Economic Record2006，82，1： | 1 |
| 10 | Finasteride does not increase the risk of high grade prostate cancer:A bias-adjus ted modeling approach显示文摘 | Mary W Redman Catherine M Tangen P H | 2008 | Cancer prev Res(Phila Pa)2008，1，3： | 1 |
| 11 | Supernatants from cocultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes invitro显示文摘 | von Dadelszen P Hurst G Redman CW | 1999 | Hum Reprod1999，14，4： | 1 |
| 12 | Measuring performance during the menstrual cycle: a model using oral contraceptives显示文摘 | REDMAN L M WEATHERBY R P | 2004 | Med Sci Sports Exe2004，36，1： | 1 |
| 13 | Theory-guided, evidence-basedreflective practice显示文摘 | Walker P H Redman R | 1999 | Nurs Sci Q1999，12，4： | 1 |
| 14 | Preeclampsia: an excessive maternal inflammatory response to pregnancy 显示文摘 | Redman C W Sacks G P Sargent I L | 1999 | Am J Obstet Gy- necol1999，180，21： | 1 |
| 15 | Theory-guided,evidence-based reflective practice显示文摘 | Walker P H Redman R | 1999 | Nurs Sci Q1999，12，4： | 1 |
| 16 | A xenobiotie- stressactivated transcription factor and its cognate target genes are preferentially expressed in root tip meristems 显示文摘 | Klinedinst S Pascuzzi P Redman J | 2000 | Plant Molecular Biology2000，42，： | 1 |
| 17 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs 显示文摘 | ZHANG J REDMAN N LITKE A P | 2011 | Bioorg Med Chem2011，19，1： | 1 |
| 18 | Synthesis and characterisation of phosphorylcholine-based polymers useful for coating blood filtration devices显示文摘 | Lewis A L Hughes P D Kirkwood L C Leppard S W Redman R P Tolhurst L A Stratford P W | | 0，，18： | 1 |
| 19 | Case-control study of severepre-eclampsia of early onset 显示文摘 | MOORE M P REDMAN C W | 1983 | Br Med J ( Clin Res Ed)1983，287，： | 1 |
| 20 | A novel phosphorylcholinecoated contact lens for extended wear use 显示文摘 | Court J L Redman R P | 2001 | Biomaterials2001，22，24： | 1 |
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