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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Temporal variability of denitrification in estuarine sediments显示文摘 | LAW C S REES A P OWENS N J P | 1991 | Estuarine Coastal and Shelf Science1991，33，1： | 1 |
| 3 | One-pot synthesis of tetrasubstituted pyrazoles-proof of regiochemistry 显示文摘 | HANEFELD U REES C W WHITE A J P | 1996 | J Chem Soc Perkin Trans 11996，13，： | 1 |
| 4 | Mustard gas casual ties显示文摘 | REES J HARPER P ELLIS F | 1991 | The Lancet1991，337，： | 1 |
| 5 | Filtration increases the correlation between water extractable organic carbon and soil microbial activity显示文摘 | REES R M PARKER J P | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 6 | The effect of temperature and relative humidity on population growth of three Liposcelis species (Psocoptera:Liposcelidae) infesting stored products in tropical countries显示文摘 | Rees D P and Walker A J | 1990 | Bulletin of Entomological esearch1990，，80： | 1 |
| 7 | Clinical safety of SonoVue, a newcontrast agent for ultrasound imaging, in healthy volunteers and in patients with chronic obstructive pulmonary disease显示文摘 | Bokor D Chambers JB Rees P J | 2001 | Invest Radiol2001，36，2： | 1 |
| 8 | Nitrous oxide: Estuarine sources and atmospheric flux 显示文摘 | LAW C S REES A P OWENS N J P | 1992 | Estuarine Coastal and Shelf Science1992，35，3： | 1 |
| 9 | A nodal model for displacement ventilation and chilled ceiling systems in office spaces显示文摘 | S J Rees P Havas | 2001 | Building and Environment2001，36，6： | 1 |
| 10 | An evaluation of effect of pterygopalatine fossa injection with local anesthetic and adrenalin in the control of nasal bleeding during endoscopic sinus surgery显示文摘 | Wormald P J Athanasiadis T Rees G | 2005 | Am J Rhinol2005，19，3： | 1 |
| 11 | Direct validation of annual increments in the otoliths of juvenile southern bluefin tuna, Thunnus maccoyii, by means of a largescale mark-recapture experiment with strontium chloride 显示文摘 | Clear N P Gunn J S Rees A J | 2000 | Fish Bull2000，98，1： | 1 |
| 12 | Fine - scale ac- tivity patterns in high -level visual areas encode the category of invisible objects 显示文摘 | STERZER P HAYNES J D REES G | 2008 | J Vis2008，8，15： | 1 |
| 13 | Design and stability analysis of networked control systems with random communication time delay using the modified MPC显示文摘 | Liu G P Mu J X Rees D Chai S C | 2006 | International Journal of Control2006，79，4： | 1 |
| 14 | Numerical investigation of transient buoyant flow in a room with a displacement ventilation and chilled ceiling system显示文摘 | REES S J MCGuirk J J HAVES P | 2001 | International Journal of H eat and Mass Transfer2001，44，16： | 1 |
| 15 | Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus 显示文摘 | Esposito M Grusovin MG Rees J Karasoulos D Felice P Alissa R | 2010 | Cochrane Database Syst Rev2010，，3： | 1 |
| 16 | The liverpool telescope: performance and first results显示文摘 | Steele I A Smith R J Rees P C | 2004 | SPIE2004，5489，： | 1 |
| 17 | Elastic modulus of the periodontal ligament显示文摘 | REES J S JACOBSEN P H | 1997 | Biomaterials1997，18，14： | 1 |
| 18 | Filtration increases the correlation between water extractable organic carbon and soil microbial activity 显示文摘 | REES R M PARKER J P | 2005 | Soil Biology and Biochemistry2005，37，12： | 1 |
| 19 | Solid-phans organic reactions: a review of the recent literature显示文摘 | Hermkens P H H Ottenheijm H C J Rees D | 1996 | Tetrahedron1996，52，： | 1 |
| 20 | Measurement of the inorganic pyrophosphate in tissure of Pisum sntivum L 显示文摘 | Edwards J ap Rees T Wilson P M | 1984 | Planta1984，162，： | 1 |
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