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您的检索式：作者名="REN WenXiu"
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| 1 | Anatomical variations of living and fossil Liquidambar leaves:A proxy for paleoenvironmental reconstruction显示文摘Based on living L.formosana,we have established that such epidermal cell properties as epidermal cell circumference(Circum.) ,undulation index(UI) ,epidermal cell area(EA) on both upper and lower epidermis and the corresponding epidermal cell density(ED) ,are suitable to differentiate between sun and shade leaves.Also,stomatal properties on the lower epidermis,including stomatal length(SL) ,stomatal pore length(PL) and the corresponding stomatal density(SD) ,are reliable parameters to identify sun/shade morphotypes.Then this anatomical approach was applied to 18 leaf remains of L.miosinica from the Miocene Xiannanshan Formation,Zhejiang Province(eastern China) ,and the fossil leaves were sorted into two groups,namely,sun and shade morphotypes.It indicates that anatomical differences between sun and shade leaves found in living species could be used for fossil leaves.Notably,the variation of UI between sun and shade morphotypes is larger on the upper epidermis as compared with the lower epidermis,showing that the UI on the upper epidermis is more sensitive to environmental changes.In addition,anatomical features are more variable in sun leaves than in shade leaves for both modern and fossil Liquidambar,suggesting sun leaves may be more sensitive to environmental changes.Sun leaves can then be a better indicator of paleoenvironmental change.Thus,stomatal parameters of sun morphotype should be adopted on reconstructing paleoenvironments using Liquidambar leaf remains.On the other hand,the three-lobed fossil L.miosinica leaf assemblage in the Xiananshan Formation is represented by an almost similar percentage of sun and shade morphotypes(56%and 44%,respectively) ,which is attributed to the short transport before deposition.As a result,identifying sun/shade morphotypes are very useful in reconstructing paleoenvironments based on fossil leaves of Liquidambar. | XIAO Liang SUN BaiNian LI XiangChuan REN WenXiu JIA Hui | 2011 | Science China Earth Sciences2011，54，4： | 4 |
| 2 | Qinzhi Zhudan formula improves memory and alleviates neuroinflammation in vascular dementia rats partly by inhibiting the TNFR1-mediated TNF pathway显示文摘Objective: The Qinzhi Zhudan formula(QZZD) exhibits a prominent therapeutic effect in the treatment of vascular dementia(VaD). This study combined a network pharmacology approach and experimental validation to identify the underlying biological mechanism of QZZD against VaD.Methods: Male Wistar rats received bilateral common carotid artery occlusion(BCCAO) surgery, and after4 weeks of intragastric administration of QZZD, the therapeutic effect was assessed using the Morris water maze test and cerebral blood flow(CBF) assessment. Hematoxylin and eosin staining, Nissl staining, and electron microscopy were used to measure the histopathological changes in the neurons of rats. The effect of QZZD treatment on hippocampal neurotransmitters was assessed by high-performance liquid chromatography with electrochemical detection and liquid chromatography mass spectrometry.Immunofluorescence was used to observe VaD-induced microglia activation. The inflammatory cytokine levels were assessed by enzyme linked immunosorbent assay. Western blot was used to examine the TNFR1-mediated TNF pathway, which was screened out by network pharmacology analysis.Results: QZZD treatment alleviated pathological changes and neuronal damage in VaD rats and attenuated their cognitive impairment. In addition, QZZD increased CBF and the expression of acetylcholine and 5-hydroxytryptamine in the hippocampal region. Notably, QZZD inhibited microglial activation and the expression of IL-6 and TNF-a. Network pharmacology and western blot indicated that QZZD inhibited the levels of TNFR1, NF-κBp65, p-ERK, TNF-a, and IL-6, which are related to the TNFR1-mediated TNF signaling pathway.Conclusion: QZZD clearly improved learning and memory function, reduced brain pathological damage,elevated CBF and hippocampal neurotransmitter levels, and alleviated neuroinflammation of VaD rats partly by inhibiting the TNFR1-mediated TNF pathway, indicating its potential value in the clinical therapy of VaD. | Shuling Liu Fafeng Cheng Beida Ren Wenxiu Xu Congai Chen Chongyang Ma Xiaole Zhang Feifei Tang Qingguo Wang Xueqian Wang | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，3： | 0 |
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