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| 1 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 2 | Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone:nuleotide sequence and expression in Escherichia coli K-12显示文摘 | Goosen N Harold P A H Rene G M H | 1989 | J Bacteriol1989，171，1： | 1 |
| 3 | Detection of mam- maglobin mRNA in peripheral blood is associated with high grade breast cancer: Interim results of a prospective cohort study显示文摘 | Kaidi M Renee H M Megan B R | 2008 | BMC Cancer2008，8，： | 1 |
| 4 | Pharmacokinetics of sunitinib in hemodialysis 显示文摘 | IZZEDINE H ETIENNE - GRIMALDI M C RENEE N | 2009 | Ann Oncol2009，20，1： | 1 |
| 5 | The effect of intrapartum epidural analgesia on nulliparous labor: a randomized controlled prospective trial显示文摘 | JAMES A DANIEL H RENE M | 1993 | Am J Obstet Gynecol1993，169，： | 1 |
| 6 | Selective sparing of goblet cells and paneth cells in the intestine of methotrexatetreated rats显示文摘 | VERBURG M RENES I B MEIJER H P | 2000 | Am J Physiol Gastroiutest Liver Physiol2000，279，5： | 1 |
| 7 | Corporate Diversification, and Firm Value显示文摘 | Lang Larry H P Rene M Stulz Tobin' s Q | 1994 | Joumal of Political Economy1994，，102： | 1 |
| 8 | Arsenate toxicity: Effects on oxidative stress response molecules and enzymes in red clover plants 显示文摘 | Rene M Barbel L Sylvia H | 2002 | Plant Science2002，163，： | 1 |
| 9 | Photobiological hydrogen production photochemical efficiency and bloreactor design 显示文摘 | Akkerman I Janssen M Rocha J Rene H W | 2002 | International Journal of Hydrogen Energy2002，27，11： | 1 |
| 10 | Corporate Diversification and Firm Performance显示文摘 | LANG H P RENE M STULZ TOBIN'S Q | 1994 | Journal of Political Economics and Management Strategy1994，，102： | 1 |
| 11 | Checking out the G2/M transition显示文摘 | VERONIQUE A J S RENE H M | 2001 | Biochim Biophys Acta2001，1519，： | 1 |
| 12 | Psycho logical distress, social support and social support see- king:A prospective study among primary mental health care patients显示文摘 | Elisabeth H M Eurelings B Rene F W | 1995 | Social Science & Medicine1995，40，8： | 1 |
| 13 | Health assessment at local level with unknown input exeitation显示文摘 | Hasan K Rene M Achintya H | 2005 | Journal of Structural Engineering2005，131，6： | 1 |
| 14 | Integrated microwave photonics显示文摘 | DAVID M CHRIS R RENE H | 2013 | Laser Photonics Review2013，7，4： | 1 |
| 15 | Strategies for sustainable development of industrial park in Ulsan,South Korea From spontaneous evolution to systematic expansion of industrial symbiosis显示文摘 | PARK H S RENE E R CHOI S M | 2006 | Journal of EnvironmentalManagement2006，，12： | 1 |
| 16 | Arsenate toxicity:effects on oxidative stress response molecules and enzymes in red clover plants显示文摘 | Rene M Barbel L Sylvia H Hans B | 2002 | Plant Science2002，163，： | 1 |
| 17 | Acetate as a carbon spurce for hydrogen production by photosynthetic bacteria显示文摘 | Maria J Jorge M S Rene H | 2001 | J biotechnology2001，85，： | 1 |
| 18 | In-plane ultrasoundguided thoracic paravertebral block:a preliminary report of 36 cases with radiologic confirmation of catheter position显示文摘 | RENES S H BRUHN J GIELEN M J | 2010 | Reg Anesth Pain Med2010，35，2： | 1 |
| 19 | Stulz,Tobin's q corporate diversification and firm performance显示文摘 | Larry H P Lang Rene M | | Journal of Political Economy0，1994，： | 1 |
| 20 | Removal of BTEX compounds by industrial sludge microbes in batch systems: statistical analysis of main and interaction effects 显示文摘 | Jo M S Rene E R Kim S H | 2008 | World Journal of Microbiology & Biotechnology2008，24，1： | 1 |
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