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| 1 | Higher rates of autism and attention deficit/hyperactivity disorder in American children:Are food quality issues impacting epigenetic inheritance?显示文摘In the United States,schools offer special education services to children who are diagnosed with a learning or neurodevelopmental disorder and have difficulty meeting their learning goals.Pediatricians may play a key role in helping children access special education services.The number of children ages 6-21 in the United States receiving special education services increased 10.4%from 2006 to 2021.Children receiving special education services under the autism category increased 242%during the same period.The demand for special education services for children under the developmental delay and other health impaired categories increased by 184%and 83%respectively.Although student enrollment in American schools has remained stable since 2006,the percentage distribution of children receiving special education services nearly tripled for the autism category and quadrupled for the developmental delay category by 2021.Allowable heavy metal residues remain persistent in the American food supply due to food ingredient manufacturing processes.Numerous clinical trial data indicate heavy metal exposures and poor diet are the primary epigenetic factors responsible for the autism and attention deficit hyperactivity disorder epidemics.Dietary heavy metal exposures,especially inorganic mercury and lead may impact gene behavior across generations.In 2021,the United States Congress found heavy metal residues problematic in the American food supply but took no legislative action.Mandatory health warning labels on select foods may be the only way to reduce dietary heavy metal exposures and improve child learning across generations. | Renee J Dufault Raquel A Crider Richard C Deth Roseanne Schnoll Steven G Gilbert Walter J Lukiw Amanda L Hitt | 2023 | World Journal of Clinical Pediatrics2023，12，2： | 1 |
| 2 | Analisys of mixed-mode fracture in concrete显示文摘 | Rots J G Rene de Borst | 1987 | Journal of Structural Engineering1987，3，11： | 1 |
| 3 | Proteomic analysis of log to stationary growth phase Lactobacillus plantarum cells and a 2-DE database显示文摘 | COHEN D P A RENES J BOUWMAN F G | | 0，，： | 1 |
| 4 | Flavonolignans from Hyparrhenia hirta显示文摘 | Mohamed B Nigel C V Renee J G | 2002 | Phytochemistry2002，60，： | 1 |
| 5 | Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells显示文摘 | Van-Summeren A Renes J Bouwman F G | 2011 | Toxicol Sci2011，120，1： | 1 |
| 6 | A survey of antifungal compounds from higher plants,1982-1993显示文摘 | RENEE J G JEFFREY B H | 1994 | Phytochemistry1994，37，1： | 1 |
| 7 | Acacetin glycosides as taxonomic markers in Calamintha and Micromeria 显示文摘 | Renee J G Maria R E Nigel C V | 2001 | Phytochemistry2001，58，6： | 1 |
| 8 | Lung injury depends on distribution ofpulmonary blood flow prior to its administration显示文摘 | Rene G Timothy J Mc Carthy | 1999 | Am J Respir Crit Care Med1999，159，2： | 1 |
| 9 | Vertical infraclavicular brachial plexus block:needle redirection after elicitation of elbow flexion显示文摘 | Moayeri N Renes S van Geffen G J | 2009 | Reg Anesth Pain Med2009，34，3： | 1 |
| 10 | Comparison of statistical indices using third order statistics for nonlinearity detection显示文摘 | Caillec L Marc J Rene G | 2004 | Signal Processing2004，84，3： | 1 |
| 11 | Vertical infraclavicular brachial plexus block:needle redirection after elicitation of elbow flexion显示文摘 | Moayeri N Renes S van Geffen G J | 2009 | Reg Anesth Pain Med2009，34，3： | 1 |
| 12 | Structured codes improve the Bennett Brassard 84 quantum key rate显示文摘 | G Smith J M Renes J A Smolin | 2008 | Phys Rev Lett2008，100，17： | 1 |
| 13 | Comparison of statistical indices using third order statistics for nonlinearity detection 显示文摘 | CAILLEC L MARC J RENE G | 2004 | Signal Processing2004，84，3： | 1 |
| 14 | Data exchange:Semantics and query answering显示文摘 | Fagin Ronald Kolaitis Phokion G Miller Renee J | 2005 | Theoretical Computer Science2005，336，1： | 1 |
| 15 | Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development显示文摘Pre-natal and post-natal chemical exposures and co-exposures from a variety of sources including contaminated air,water,soil,and food are common and associated with poorer birth and child health outcomes.Poor diet is a contributing factor in the development of child behavioral disorders.Child behavior and learning can be adversely impacted when gene expression is altered by dietary transcription factors such as zinc insufficiency or deficiency or by exposure to toxic substances permitted in our food supply such as mercury,lead,or organophosphate pesticide residue.Children with autism spectrum disorder and attention deficit hyperactivity disorders exhibit decreased or impaired PON1 gene activity which is needed by the body to metabolize and excrete neurotoxic organophosphate pesticides.In this current review we present an updated macroepigenetic model that explains how dietary inorganic mercury and lead exposures from unhealthy diet may lead to elevated blood mercury and/or lead levels and the development of symptoms associated with the autism and attention deficithyperactivity disorders.PON1 gene activity may be suppressed by inadequate dietary calcium,selenium,and fatty acid intake or exposures to lead or mercury.The model may assist clinicians in diagnosing and treating the symptoms associated with these childhood neurodevelopmental disorders.Recommendations for future research are provided based on the updated model and review of recently published literature. | Renee J Dufault Mesay M Wolle H M Skip Kingston Steven G Gilbert Joseph A Murray | 2021 | World Journal of Methodology2021，11，4： | 1 |
| 16 | (+)-And(-)–bomeol:efficacious positive modulators of GABA action at human recombinantα1β2γ2 L GABA(A)receptors显示文摘 | RENEE E G ERICA L C GRAHAM A R J | 2005 | Biochemical Pharmacology2005，69，7： | 1 |
| 17 | Proteomic analysis of log to stationary growth phase Lactobacillus plantarum cells and a 2 - DE database显示文摘 | Cohen D P Renes J Bouwman F G | 2006 | Proteomics2006，6，： | 1 |
| 18 | Minimumeffective volume of local anesthetic for shoulder analgesia by ultra-sound -guided block at root C7 with assessment of pulmonaryfunction显示文摘 | RENES S H VAN GEFFEN G J RETTIG H C | 2010 | Reg Anesth Pain Med2010，35，6： | 1 |
| 19 | Backbone methylated analogues of the principle receptor binding region of human parathyroid hormone显示文摘 | Jean - Rene' Barbier T J G Thomas Dean Susanne Ma- clean | 2005 | Biological Chemistry2005，280，23： | 1 |
| 20 | A preprocessing algorithm for edge detection with multiple scales of resolution显示文摘 | RENE G AARNINK JEAN J M C H DE LA ROSETTE | 1997 | European Journal of Ultrasound1997，5，： | 1 |
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