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| 1 | Validation of a new scoring system: Rapid assessment faecal incontinence score显示文摘AIM: To implement a quick and simple test- rapid assessment faecal incontinence score(RAFIS) and show its reliability and validity.METHODS: From March 2008 through March 2010, we evaluated a total of 261 consecutive patients, including 53 patients with faecal incontinence. Demographic and comorbidity information was collected. In a single visit, patients were administered the RAFIS. The results obtained with the new score were compared with those of both Wexner score and faecal incontinence quality of life scale(FIQL) questionnaire. The patient withoutinfluence of the surgeon completed the test. The role of surgeon was explaining the meaning of each section and how he had to fill. Reliability of the RAFIS score was measured using intra-observer agreement and Cronbach's alpha(internal consistency) coefficient. Multivariate analysis of the main components within the different scores was performed in order to determine whether all the scores measured the same factor and to conclude whether the information could be encompassed in a single factor. A sample size of 50 patients with faecal incontinence was estimated to be enough to detect a correlation of 0.55 or better at 5% level of significance with 80% power.RESULTS: We analysed the results obtained by 53 consecutive patients with faecal incontinence(median age 61.55 ± 12.49 years) in the three scoring systems. A total of 208 healthy volunteers(median age 58.41 ± 18.41 years) without faecal incontinence were included in the study as negative controls. Pearson's correlation coefficient between 'state' and 'leaks' was excellent(r = 0.92, P < 0.005). Internal consistency in the comparison of 'state' and 'leaks' yielded also excellent correlation(Cronbach's α = 0.93). Results in each score were compared using regression analysis and a correlation value of r = 0.98 was obtained with Wexner score. As regards FIQL questionnaire, the values of 'r ' for the different subscales of the questionnaire were: 'lifestyle' r =-0.87, 'coping/behaviour' r =-0.91, 'depression' r =-0.36 and 'embarrassment' r =-0.90,(P < 0.01). A multivariate analysis showed that all the scoring systems measured the same factor. A single factor may explain 80.84% of the variability of FI, so all the scoring systems measure the same factor. Patient's continence improves when RAFIS and Jorge-Wexner scores show low values and when the values obtained in the FIQL questionnaire are high.CONCLUSION: RAFIS is a valid and reliable tool to assess Faecal Incontinence. | Fernando de la Portilla Arantxa Calero-Lillo Rosa M Jiménez-Rodríguez Maria L Reyes Manuela Segovia-González María Victoria Maestre Ana M García-Cabrera | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 5 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 4 | Decreased resistin expression in mice with different sensitivities to a high-fat diet显示文摘 | Le Lay S L Boucher J Rey A | 2001 | Biochem Biophys Res Commun2001，289，： | 1 |
| 5 | microRNA directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems 显示文摘 | Kim J Jung J H Reyes J L kim Y S Kim S Y Chung K S Kiln J A Lee M Lee Y Kim V N | 2005 | The Plant Journal2005，42，： | 1 |
| 6 | Comparative study of the expression of metalloproteases and their inhibitors in different localizations within primary tumours and in metastatic lymph nodes of breast cancer显示文摘 | GARCA M F GONZ(A)LEZ REYES S GONZLEZ L O | 2010 | Int J Exp Pathol2010，91，4： | 1 |
| 7 | HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma显示文摘 | Hristov A C Cope L Reyes M D | 2009 | Mod Pathol2009，22，1： | 1 |
| 8 | Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination 显示文摘 | Morice P Juncker L Rey A | 2000 | Fertil Steril2000，74，4： | 1 |
| 9 | Pollutant formation and emissions from cement kiln stack using a solid recov- ered huel from municipal solid waste 显示文摘 | CONESA J A REY L EGEA S | 2011 | Environ Sci Teclmol2011，45，13： | 1 |
| 10 | Blood-brain barri- er abnormalities caused by exposure to HIV-1 gp120 protec- tion by gene delivery of antioxidant enzymes显示文摘 | Louboutin J P Reyes B A Agrawal L | 2010 | Neurobiol Dis2010，38，2： | 1 |
| 11 | Composition controlled spin polarization in Co1-x FexS2 alloys 显示文摘 | C Leighton M Manno A Cady J W Freeland L Wang K Umenoto R M Wentzcovitch T Y Chen C L Chien P L Kuhns M J R Hoch A P Reyes W G Moulton E D Dahlberg J Checkelsky J Eckert | 2007 | Journal of Physics : Condensed Matter2007，19，31： | 1 |
| 12 | Is there a role for copper in neurodegenerative diseases? 显示文摘 | Cerpa W Varela-Nallar L Reyes A E | 2005 | Mol Aspects Med2005，26，： | 1 |
| 13 | Influence of inflammatory nociception on the anxiolytic-like effect of diazepam- and buspirone in rats 显示文摘 | Femandez-Guasti A Reyes R Martinez-Mota L | 2005 | Psyehopharmacology ( Berl )2005，180，： | 1 |
| 14 | Prevalence of Demodex mites in eyelashes among people of Oaxaca, Mexico 显示文摘 | Vargas Arzola J Reyes Velasco L Segura Salvador A | 2012 | Acta Microbiol Immunol Hung2012，59，2： | 1 |
| 15 | Gas sensing with frlms of nanocrytallineW03 and Pd made by advanced reactive gas deposition 显示文摘 | Hoel A Reyes L F Saukko S | 2005 | Sensors and Actuators B2005，，105： | 1 |
| 16 | Comparison of the Salmonella (Ames) test, umu test, and the SOS chromotests for detecting genotoxins显示文摘 | McDaniels A E Reyes A L Wymer L J | 1990 | Environmental and Molecular Mutagenesis1990，16，： | 1 |
| 17 | Self-reported emotional intel- ligence, burnout and engagement among staff in services for people with intellectual disabilities显示文摘 | DuraN A Extremera N Rey L | 2004 | Psychological Reports2004，95，2： | 1 |
| 18 | Effect of rearing system on growth,body composition and development of digestive system in young lamb显示文摘 | Fuente D L Teion D Rey A J | 1998 | Journal of Animal Physiology and Animal Nutrition1998，，8： | 1 |
| 19 | Observer agreement in the scoring of the activity and chronicity indexes of lupus nephritis 显示文摘 | Gamba G Reyes E Angeles A Quintanilla L Calva J Pefia JC | 1991 | Nephron1991，57，1： | 1 |
| 20 | Genotoxic activity detected in soils from a hazardous waste site by the Ames test and an SOS colorimetric test显示文摘 | REYES A L WYMER L J | 1993 | Environ Mol Mutagen1993，22，2： | 1 |
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